Efficacy of fractional flow reserve measurement in the assessment of stenotic lesions of coronary artery.
Context: The decision to perform an intervention on a narrowed coronary artery depends on the ischemia caused by the stenosis. The indication for intervention usually applies to cases with ≥70% stenosis of vascular diameter because of the risk of myocardial ischemia. Aims: To define the efficacy...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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GarVal Editorial Ltda.
2022-01-01
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| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | https://jppres.com/jppres/pdf/vol10/jppres21.1177_10.1.128.pdf |
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| author | Anh Binh Ho Ngoc Son Nguyen Le Xuan Ngo Thuy Phuong Cao-Thi Anh Khoa Phan Anh Tien Hoang Cuu Loi Nguyen |
| author_facet | Anh Binh Ho Ngoc Son Nguyen Le Xuan Ngo Thuy Phuong Cao-Thi Anh Khoa Phan Anh Tien Hoang Cuu Loi Nguyen |
| author_sort | Anh Binh Ho |
| collection | DOAJ |
| description | Context: The decision to perform an intervention on a narrowed coronary artery depends on the ischemia caused by the stenosis. The indication for intervention usually applies to cases with ≥70% stenosis of vascular diameter because of the risk of myocardial ischemia.
Aims: To define the efficacy of fractional flow reserve (FFR) measurement in the evaluation of coronary artery stenosis.
Methods: This prospective study was conducted on patients with intermediate coronary artery stenosis who underwent quantitative coronary angiography after coronary computed tomography angiography.
Results: The study population consisted of 46 men and 26 women with a mean age of 66.0 ± 12.9 years. FFR was significantly correlated with the grade of angina pectoris (r = – 0.387; p<0.01) and showed a negative correlation with percentage diameter stenosis (r = – 0.241, p<0.05) and a positive correlation with the minimal lumen diameter (MLD; r = 0.377, p<0.05). The cut-off value to predict positive FFR was >55.62% diameter stenosis and MLD ≤ 1.08 mm. FFR ≤ 0.80 indicating intervention and FFR > 0.80 indicating medical therapy were observed in 56.9% and 43.1% of the cases, respectively. No major cardiac complications occurred during 12 months of follow-up in both groups.
Conclusions: FFR measurements for intermediate stenosis of the coronary artery should be used to evaluate the possibility of myocardial ischaemia. If FFR is not available, a cut-off point of >55.62% diameter stenosis or MLD ≤ 1.08 mm can be used to predict the FFR results. |
| first_indexed | 2024-12-13T14:33:29Z |
| format | Article |
| id | doaj.art-f59400682e0a43cda32c516f9e6fb8ca |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-12-13T14:33:29Z |
| publishDate | 2022-01-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-f59400682e0a43cda32c516f9e6fb8ca2022-12-21T23:41:47ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502022-01-01101128137Efficacy of fractional flow reserve measurement in the assessment of stenotic lesions of coronary artery.Anh Binh Ho0Ngoc Son Nguyen1Le Xuan Ngo2Thuy Phuong Cao-Thi3Anh Khoa Phan4Anh Tien Hoang5Cuu Loi Nguyen6Department of Emergency and Cardiology Interventional, Hue Central Hospital, Hue city, Vietnam.Department of Emergency and Cardiology Interventional, Hue Central Hospital, Hue city, Vietnam.Department of Emergency and Cardiology Interventional, Hue Central Hospital, Hue city, Vietnam.Department of Emergency and Cardiology Interventional, Hue Central Hospital, Hue city, Vietnam.Department of Emergency and Cardiology Interventional, Hue Central Hospital, Hue city, Vietnam.Cardiology Department, Hue University of Medicine and Pharmacy, Hue University, Hue city, Vietnam.Department of Emergency and Cardiology Interventional, Hue Central Hospital, Hue city, Vietnam.Context: The decision to perform an intervention on a narrowed coronary artery depends on the ischemia caused by the stenosis. The indication for intervention usually applies to cases with ≥70% stenosis of vascular diameter because of the risk of myocardial ischemia. Aims: To define the efficacy of fractional flow reserve (FFR) measurement in the evaluation of coronary artery stenosis. Methods: This prospective study was conducted on patients with intermediate coronary artery stenosis who underwent quantitative coronary angiography after coronary computed tomography angiography. Results: The study population consisted of 46 men and 26 women with a mean age of 66.0 ± 12.9 years. FFR was significantly correlated with the grade of angina pectoris (r = – 0.387; p<0.01) and showed a negative correlation with percentage diameter stenosis (r = – 0.241, p<0.05) and a positive correlation with the minimal lumen diameter (MLD; r = 0.377, p<0.05). The cut-off value to predict positive FFR was >55.62% diameter stenosis and MLD ≤ 1.08 mm. FFR ≤ 0.80 indicating intervention and FFR > 0.80 indicating medical therapy were observed in 56.9% and 43.1% of the cases, respectively. No major cardiac complications occurred during 12 months of follow-up in both groups. Conclusions: FFR measurements for intermediate stenosis of the coronary artery should be used to evaluate the possibility of myocardial ischaemia. If FFR is not available, a cut-off point of >55.62% diameter stenosis or MLD ≤ 1.08 mm can be used to predict the FFR results.https://jppres.com/jppres/pdf/vol10/jppres21.1177_10.1.128.pdfcoronary arteryfractional flow reservestenosis |
| spellingShingle | Anh Binh Ho Ngoc Son Nguyen Le Xuan Ngo Thuy Phuong Cao-Thi Anh Khoa Phan Anh Tien Hoang Cuu Loi Nguyen Efficacy of fractional flow reserve measurement in the assessment of stenotic lesions of coronary artery. Journal of Pharmacy & Pharmacognosy Research coronary artery fractional flow reserve stenosis |
| title | Efficacy of fractional flow reserve measurement in the assessment of stenotic lesions of coronary artery. |
| title_full | Efficacy of fractional flow reserve measurement in the assessment of stenotic lesions of coronary artery. |
| title_fullStr | Efficacy of fractional flow reserve measurement in the assessment of stenotic lesions of coronary artery. |
| title_full_unstemmed | Efficacy of fractional flow reserve measurement in the assessment of stenotic lesions of coronary artery. |
| title_short | Efficacy of fractional flow reserve measurement in the assessment of stenotic lesions of coronary artery. |
| title_sort | efficacy of fractional flow reserve measurement in the assessment of stenotic lesions of coronary artery |
| topic | coronary artery fractional flow reserve stenosis |
| url | https://jppres.com/jppres/pdf/vol10/jppres21.1177_10.1.128.pdf |
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