Smartphone-Based Rigid Endoscopy Device with Hemodynamic Response Imaging and Laser Speckle Contrast Imaging
Modern smartphones have been employed as key elements in point-of-care (POC) devices due to remarkable advances in their form factor, computing, and display performances. Recently, we reported a combination of the smartphone with a handheld endoscope using laser speckle contrast imaging (LSCI), sugg...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/13/8/816 |
| _version_ | 1797585359167553536 |
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| author | Youngkyu Kim Woo June Choi Jeongmin Oh Kwanhee Lee Jun Ki Kim |
| author_facet | Youngkyu Kim Woo June Choi Jeongmin Oh Kwanhee Lee Jun Ki Kim |
| author_sort | Youngkyu Kim |
| collection | DOAJ |
| description | Modern smartphones have been employed as key elements in point-of-care (POC) devices due to remarkable advances in their form factor, computing, and display performances. Recently, we reported a combination of the smartphone with a handheld endoscope using laser speckle contrast imaging (LSCI), suggesting potential for functional POC endoscopy. Here, we extended our work to develop a smartphone-combined multifunctional handheld endoscope using dual-wavelength LSCI. Dual-wavelength LSCI is used to monitor the changes in dynamic blood flow as well as changes in the concentration of oxygenated (HbO<sub>2</sub>), deoxygenated (Hbr), and total hemoglobin (HbT). The smartphone in the device performs fast acquisition and computation of the raw LSCI data to map the blood perfusion parameters. The flow imaging performance of the proposed device was tested with a tissue-like flow phantom, exhibiting a speckle flow index map representing the blood perfusion. Furthermore, the device was employed to assess the blood perfusion status from an exteriorized intestine model of rat in vivo during and after local ischemia, showing that blood flow and HbO<sub>2</sub> gradually decreased in the ischemic region whereas hyperemia and excess increases in HbO<sub>2</sub> were observed in the same region right after reperfusion. The results indicate that the combination of LSCI with smartphone endoscopy delivers a valuable platform for better understanding of the functional hemodynamic changes in the vasculatures of the internal organs, which may benefit POC testing for diagnosis and treatment of vascular diseases. |
| first_indexed | 2024-03-11T00:05:56Z |
| format | Article |
| id | doaj.art-f597f4abf7f645faaf5dc2aafe508896 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-11T00:05:56Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-f597f4abf7f645faaf5dc2aafe5088962023-11-19T00:25:40ZengMDPI AGBiosensors2079-63742023-08-0113881610.3390/bios13080816Smartphone-Based Rigid Endoscopy Device with Hemodynamic Response Imaging and Laser Speckle Contrast ImagingYoungkyu Kim0Woo June Choi1Jeongmin Oh2Kwanhee Lee3Jun Ki Kim4Biomedical Engineering Research Center, Asan Medical Center, Seoul 05505, Republic of KoreaSchool of Electrical and Electronics Engineering, Chung-Ang University, Seoul 06974, Republic of KoreaDepartment of Biomedical Engineering, College of Medicine, University of Ulsan, Seoul 05505, Republic of KoreaDepartment of Biomedical Engineering, College of Medicine, University of Ulsan, Seoul 05505, Republic of KoreaBiomedical Engineering Research Center, Asan Medical Center, Seoul 05505, Republic of KoreaModern smartphones have been employed as key elements in point-of-care (POC) devices due to remarkable advances in their form factor, computing, and display performances. Recently, we reported a combination of the smartphone with a handheld endoscope using laser speckle contrast imaging (LSCI), suggesting potential for functional POC endoscopy. Here, we extended our work to develop a smartphone-combined multifunctional handheld endoscope using dual-wavelength LSCI. Dual-wavelength LSCI is used to monitor the changes in dynamic blood flow as well as changes in the concentration of oxygenated (HbO<sub>2</sub>), deoxygenated (Hbr), and total hemoglobin (HbT). The smartphone in the device performs fast acquisition and computation of the raw LSCI data to map the blood perfusion parameters. The flow imaging performance of the proposed device was tested with a tissue-like flow phantom, exhibiting a speckle flow index map representing the blood perfusion. Furthermore, the device was employed to assess the blood perfusion status from an exteriorized intestine model of rat in vivo during and after local ischemia, showing that blood flow and HbO<sub>2</sub> gradually decreased in the ischemic region whereas hyperemia and excess increases in HbO<sub>2</sub> were observed in the same region right after reperfusion. The results indicate that the combination of LSCI with smartphone endoscopy delivers a valuable platform for better understanding of the functional hemodynamic changes in the vasculatures of the internal organs, which may benefit POC testing for diagnosis and treatment of vascular diseases.https://www.mdpi.com/2079-6374/13/8/816point-of-caresmartphonelaser speckle contrast imaginghemodynamic response imaginganimal model of ischemia |
| spellingShingle | Youngkyu Kim Woo June Choi Jeongmin Oh Kwanhee Lee Jun Ki Kim Smartphone-Based Rigid Endoscopy Device with Hemodynamic Response Imaging and Laser Speckle Contrast Imaging Biosensors point-of-care smartphone laser speckle contrast imaging hemodynamic response imaging animal model of ischemia |
| title | Smartphone-Based Rigid Endoscopy Device with Hemodynamic Response Imaging and Laser Speckle Contrast Imaging |
| title_full | Smartphone-Based Rigid Endoscopy Device with Hemodynamic Response Imaging and Laser Speckle Contrast Imaging |
| title_fullStr | Smartphone-Based Rigid Endoscopy Device with Hemodynamic Response Imaging and Laser Speckle Contrast Imaging |
| title_full_unstemmed | Smartphone-Based Rigid Endoscopy Device with Hemodynamic Response Imaging and Laser Speckle Contrast Imaging |
| title_short | Smartphone-Based Rigid Endoscopy Device with Hemodynamic Response Imaging and Laser Speckle Contrast Imaging |
| title_sort | smartphone based rigid endoscopy device with hemodynamic response imaging and laser speckle contrast imaging |
| topic | point-of-care smartphone laser speckle contrast imaging hemodynamic response imaging animal model of ischemia |
| url | https://www.mdpi.com/2079-6374/13/8/816 |
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