Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar
Abstract Aims/Introduction To study the epidemiology, genetic landscape and causes of childhood diabetes mellitus in the State of Qatar. Materials and methods All patients (aged 0–18 years) with diabetes mellitus underwent biochemical, immunological and genetic testing. American Diabetes Association...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-12-01
|
| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13610 |
| _version_ | 1819240787219578880 |
|---|---|
| author | Basma Haris Saras Saraswathi Sara Al‐Khawaga Reem Hasnah Amira Saeed Shihab Mundekkadan Noor Hamed Houda Afyouni Tasneem Abdel‐Karim Shayma Mohammed Amel Khalifa Maryam Al‐Maadheed Mahmoud Al‐Zyoud Ahmed Shamekh Ahmed Elawwa Fawziya Al‐Khalaf Sabri Boughorbel Goran Petrovski Khalid Hussain |
| author_facet | Basma Haris Saras Saraswathi Sara Al‐Khawaga Reem Hasnah Amira Saeed Shihab Mundekkadan Noor Hamed Houda Afyouni Tasneem Abdel‐Karim Shayma Mohammed Amel Khalifa Maryam Al‐Maadheed Mahmoud Al‐Zyoud Ahmed Shamekh Ahmed Elawwa Fawziya Al‐Khalaf Sabri Boughorbel Goran Petrovski Khalid Hussain |
| author_sort | Basma Haris |
| collection | DOAJ |
| description | Abstract Aims/Introduction To study the epidemiology, genetic landscape and causes of childhood diabetes mellitus in the State of Qatar. Materials and methods All patients (aged 0–18 years) with diabetes mellitus underwent biochemical, immunological and genetic testing. American Diabetes Association guidelines were used to classify types of diabetes mellitus. The incidence and prevalence of all the different types of diabetes mellitus were calculated. Results Total number of children with diabetes mellitus was 1,325 (type 1 n = 1,096, ≥1 antibody; type 2 n = 104, type 1B n = 53; maturity onset diabetes of the young n = 20; monogenic autoimmune n = 4; neonatal diabetes mellitus n = 10;, syndromic diabetes mellitus n = 23; and double diabetes mellitus n = 15). The incidence and prevalence of type 1 diabetes were 38.05 and 249.73 per 100,000, respectively, and for type 2 were 2.51 and 23.7 per 100,000, respectively. The incidence of neonatal diabetes mellitus was 34.4 per 1,000,000 live births, and in indigenous Qataris the incidence was 43.6 per 1,000,000 live births. The prevalence of type 1 diabetes and type 2 diabetes in Qatari children was double compared with other nationalities. The prevalence of maturity onset diabetes of the young in Qatar was 4.56 per 100,000. Conclusions This is the first prospective and comprehensive study to document the epidemiology and genetic landscape of childhood diabetes mellitus in this region. Qatar has the fourth highest incidence of type 1 diabetes mellitus, with the incidence and prevalence being higher in Qatari compared with non‐Qatari. The prevalence of type 2 diabetes mellitus is also higher in Qatar than in Western countries. The incidence of neonatal diabetes mellitus is the second highest in the world. GCK is the most common form of maturity onset diabetes of the young, and a large number of patients have type 1B diabetes mellitus. |
| first_indexed | 2024-12-23T14:13:34Z |
| format | Article |
| id | doaj.art-f59812d4ddf14328951e013b926c3aef |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-23T14:13:34Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-f59812d4ddf14328951e013b926c3aef2022-12-21T17:43:59ZengWileyJournal of Diabetes Investigation2040-11162040-11242021-12-0112122141214810.1111/jdi.13610Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of QatarBasma Haris0Saras Saraswathi1Sara Al‐Khawaga2Reem Hasnah3Amira Saeed4Shihab Mundekkadan5Noor Hamed6Houda Afyouni7Tasneem Abdel‐Karim8Shayma Mohammed9Amel Khalifa10Maryam Al‐Maadheed11Mahmoud Al‐Zyoud12Ahmed Shamekh13Ahmed Elawwa14Fawziya Al‐Khalaf15Sabri Boughorbel16Goran Petrovski17Khalid Hussain18Division of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarTranslational Research Sidra Medicine Doha QatarTranslational Research Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarTranslational Research Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarDivision of Endocrinology Department of Pediatrics Sidra Medicine Doha QatarAbstract Aims/Introduction To study the epidemiology, genetic landscape and causes of childhood diabetes mellitus in the State of Qatar. Materials and methods All patients (aged 0–18 years) with diabetes mellitus underwent biochemical, immunological and genetic testing. American Diabetes Association guidelines were used to classify types of diabetes mellitus. The incidence and prevalence of all the different types of diabetes mellitus were calculated. Results Total number of children with diabetes mellitus was 1,325 (type 1 n = 1,096, ≥1 antibody; type 2 n = 104, type 1B n = 53; maturity onset diabetes of the young n = 20; monogenic autoimmune n = 4; neonatal diabetes mellitus n = 10;, syndromic diabetes mellitus n = 23; and double diabetes mellitus n = 15). The incidence and prevalence of type 1 diabetes were 38.05 and 249.73 per 100,000, respectively, and for type 2 were 2.51 and 23.7 per 100,000, respectively. The incidence of neonatal diabetes mellitus was 34.4 per 1,000,000 live births, and in indigenous Qataris the incidence was 43.6 per 1,000,000 live births. The prevalence of type 1 diabetes and type 2 diabetes in Qatari children was double compared with other nationalities. The prevalence of maturity onset diabetes of the young in Qatar was 4.56 per 100,000. Conclusions This is the first prospective and comprehensive study to document the epidemiology and genetic landscape of childhood diabetes mellitus in this region. Qatar has the fourth highest incidence of type 1 diabetes mellitus, with the incidence and prevalence being higher in Qatari compared with non‐Qatari. The prevalence of type 2 diabetes mellitus is also higher in Qatar than in Western countries. The incidence of neonatal diabetes mellitus is the second highest in the world. GCK is the most common form of maturity onset diabetes of the young, and a large number of patients have type 1B diabetes mellitus.https://doi.org/10.1111/jdi.13610EpidemiologyPediatric diabetesType 1 diabetes |
| spellingShingle | Basma Haris Saras Saraswathi Sara Al‐Khawaga Reem Hasnah Amira Saeed Shihab Mundekkadan Noor Hamed Houda Afyouni Tasneem Abdel‐Karim Shayma Mohammed Amel Khalifa Maryam Al‐Maadheed Mahmoud Al‐Zyoud Ahmed Shamekh Ahmed Elawwa Fawziya Al‐Khalaf Sabri Boughorbel Goran Petrovski Khalid Hussain Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar Journal of Diabetes Investigation Epidemiology Pediatric diabetes Type 1 diabetes |
| title | Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar |
| title_full | Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar |
| title_fullStr | Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar |
| title_full_unstemmed | Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar |
| title_short | Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar |
| title_sort | epidemiology genetic landscape and classification of childhood diabetes mellitus in the state of qatar |
| topic | Epidemiology Pediatric diabetes Type 1 diabetes |
| url | https://doi.org/10.1111/jdi.13610 |
| work_keys_str_mv | AT basmaharis epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT sarassaraswathi epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT saraalkhawaga epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT reemhasnah epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT amirasaeed epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT shihabmundekkadan epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT noorhamed epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT houdaafyouni epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT tasneemabdelkarim epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT shaymamohammed epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT amelkhalifa epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT maryamalmaadheed epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT mahmoudalzyoud epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT ahmedshamekh epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT ahmedelawwa epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT fawziyaalkhalaf epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT sabriboughorbel epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT goranpetrovski epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar AT khalidhussain epidemiologygeneticlandscapeandclassificationofchildhooddiabetesmellitusinthestateofqatar |