Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors
Background: Approximately 75% of all head and neck cancer patients are treated with radiotherapy (RT). RT to the oral cavity results in acute and late adverse events which can be severe and detrimental to a patient’s quality of life and function. The purpose of this study was to explore associations...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/2/349 |
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| author | Robert L. Foote W. Scott Harmsen Adam C. Amundson Alan B. Carr Mauricio E. Gamez Yolanda I. Garces Scott C. Lester Daniel J. Ma Lisa A. McGee Eric J. Moore Michelle A. Neben Wittich Samir H. Patel David M. Routman Jean-Claude M. Rwigema Kathryn M. Van Abel Linda X. Yin Olivia M. Muller Satomi Shiraishi |
| author_facet | Robert L. Foote W. Scott Harmsen Adam C. Amundson Alan B. Carr Mauricio E. Gamez Yolanda I. Garces Scott C. Lester Daniel J. Ma Lisa A. McGee Eric J. Moore Michelle A. Neben Wittich Samir H. Patel David M. Routman Jean-Claude M. Rwigema Kathryn M. Van Abel Linda X. Yin Olivia M. Muller Satomi Shiraishi |
| author_sort | Robert L. Foote |
| collection | DOAJ |
| description | Background: Approximately 75% of all head and neck cancer patients are treated with radiotherapy (RT). RT to the oral cavity results in acute and late adverse events which can be severe and detrimental to a patient’s quality of life and function. The purpose of this study was to explore associations between RT dose to a defined oral cavity organ-at-risk (OAR) avoidance structure, provider- and patient-reported outcomes (PROs), opioid use, and hospitalization. Methods: This was a retrospective analysis of prospectively obtained outcomes using multivariable modeling. The study included 196 patients treated with RT involving the oral cavity for a head and neck tumor. A defined oral cavity OAR avoidance structure was used in all patients for RT treatment planning. Validated PROs were collected prospectively. Opioid use and hospitalization were abstracted electronically from medical records. Results: Multivariable modeling revealed the mean dose to the oral cavity OAR was significantly associated with opioid use (<i>p</i> = 0.0082) and hospitalization (<i>p</i> = 0.0356) during and within 30 days of completing RT. Conclusions: The findings of this study may be valuable in RT treatment planning for patients with tumors of the head and neck region to reduce the need for opioid use and hospitalization during treatment. |
| first_indexed | 2024-03-08T11:03:49Z |
| format | Article |
| id | doaj.art-f59c5d7f3c8e4d9186cb74489bcfdf15 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T11:03:49Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f59c5d7f3c8e4d9186cb74489bcfdf152024-01-26T15:36:14ZengMDPI AGCancers2072-66942024-01-0116234910.3390/cancers16020349Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck TumorsRobert L. Foote0W. Scott Harmsen1Adam C. Amundson2Alan B. Carr3Mauricio E. Gamez4Yolanda I. Garces5Scott C. Lester6Daniel J. Ma7Lisa A. McGee8Eric J. Moore9Michelle A. Neben Wittich10Samir H. Patel11David M. Routman12Jean-Claude M. Rwigema13Kathryn M. Van Abel14Linda X. Yin15Olivia M. Muller16Satomi Shiraishi17Department of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Quantitative Health Sciences, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Dental Specialties, Division of Esthetic and Prosthetic Dentistry, Department of Advanced Prosthodontics, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Radiation Oncology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85054, USADepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Radiation Oncology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85054, USADepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Radiation Oncology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85054, USADepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADepartment of Dental Specialties, Division of Esthetic and Prosthetic Dentistry, Department of Advanced Prosthodontics, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USADivision of Medical Physics, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USABackground: Approximately 75% of all head and neck cancer patients are treated with radiotherapy (RT). RT to the oral cavity results in acute and late adverse events which can be severe and detrimental to a patient’s quality of life and function. The purpose of this study was to explore associations between RT dose to a defined oral cavity organ-at-risk (OAR) avoidance structure, provider- and patient-reported outcomes (PROs), opioid use, and hospitalization. Methods: This was a retrospective analysis of prospectively obtained outcomes using multivariable modeling. The study included 196 patients treated with RT involving the oral cavity for a head and neck tumor. A defined oral cavity OAR avoidance structure was used in all patients for RT treatment planning. Validated PROs were collected prospectively. Opioid use and hospitalization were abstracted electronically from medical records. Results: Multivariable modeling revealed the mean dose to the oral cavity OAR was significantly associated with opioid use (<i>p</i> = 0.0082) and hospitalization (<i>p</i> = 0.0356) during and within 30 days of completing RT. Conclusions: The findings of this study may be valuable in RT treatment planning for patients with tumors of the head and neck region to reduce the need for opioid use and hospitalization during treatment.https://www.mdpi.com/2072-6694/16/2/349radiotherapyhead and neck canceroral cavityorgan at riskadverse events |
| spellingShingle | Robert L. Foote W. Scott Harmsen Adam C. Amundson Alan B. Carr Mauricio E. Gamez Yolanda I. Garces Scott C. Lester Daniel J. Ma Lisa A. McGee Eric J. Moore Michelle A. Neben Wittich Samir H. Patel David M. Routman Jean-Claude M. Rwigema Kathryn M. Van Abel Linda X. Yin Olivia M. Muller Satomi Shiraishi Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors Cancers radiotherapy head and neck cancer oral cavity organ at risk adverse events |
| title | Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors |
| title_full | Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors |
| title_fullStr | Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors |
| title_full_unstemmed | Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors |
| title_short | Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors |
| title_sort | mean oral cavity organ at risk dose predicts opioid use and hospitalization during radiotherapy for patients with head and neck tumors |
| topic | radiotherapy head and neck cancer oral cavity organ at risk adverse events |
| url | https://www.mdpi.com/2072-6694/16/2/349 |
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