The Role of Glucosamine Chondrotin Sulfate in the Treatment of Osteoarthritis of Knee
Background: Osteoarthritis (OA) currently seems inevitable and unavoidable for a large swath of the population .its etiology relates to a strong ,but complex ,non mendelian genetic basis ,combined with mechanical and metabolic factors that cause molecular alterations the end results of which affect...
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| Format: | Article |
| Language: | English |
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University of Baghdad/ Al-Kindy College of Medicine
2013-01-01
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| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/561 |
| _version_ | 1811275107262267392 |
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| author | Sadeq A. AlMukhtar Sinan Al-Muktar |
| author_facet | Sadeq A. AlMukhtar Sinan Al-Muktar |
| author_sort | Sadeq A. AlMukhtar |
| collection | DOAJ |
| description |
Background: Osteoarthritis (OA) currently seems
inevitable and unavoidable for a large swath of the
population .its etiology relates to a strong ,but
complex ,non mendelian genetic basis ,combined
with mechanical and metabolic factors that cause
molecular alterations the end results of which
affect the whole joint .Glucosamine and
chondrotin sulfate alone or in combination may be
of benefit to a subgroup of individuals who have
knee pain due to OA.
Glucosamine has been shown to alter cartiage turn
over in patients with OA undergoing physical
training
Aim of the study: To find the validity of
glucosamine chondrotin sulfate in treatment of
grade 1 and 2 OA.
Methods: the sample of 280 patients (418 knee)
were divided in to two groups , group A (132
patient) treated by classical methods by
glucosamine chondrotin sulfate for one year. For
both groups different parameters were used
including pain stiffness effusion crepitus and genu
varum and different radiological findings and we
used MRI for evaluation pre and post treatment
Result: Female/ male ratio was 2.89 the highest
age group was ( 60-69) year regarding the clinical
presentation of patients the commonest clinical
presentation were pain and stiffness and the MRI
finding including bone marrow edema shows good
indicator for response to treatment .
Conclusion: Pain ,stiffness and crepitus were
common presentation of OARelief of pain
andstiffness were related to decrease of effusion
and bone marrow edema which is the result of
using nonsteroidal anti-inflammatory drugs with
glucosamine chondroitin sulfate more than when
non steroidal anti- inflammatory drugs alone.
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| first_indexed | 2024-04-12T23:32:09Z |
| format | Article |
| id | doaj.art-f59d9ab391264d589fc8572e8374132a |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-04-12T23:32:09Z |
| publishDate | 2013-01-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-f59d9ab391264d589fc8572e8374132a2022-12-22T03:12:16ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652013-01-0191The Role of Glucosamine Chondrotin Sulfate in the Treatment of Osteoarthritis of KneeSadeq A. AlMukhtar0Sinan Al-Muktar1department of surgery, al- kindy college of medicinedepartment of surgery, al- kindy college of medicine Background: Osteoarthritis (OA) currently seems inevitable and unavoidable for a large swath of the population .its etiology relates to a strong ,but complex ,non mendelian genetic basis ,combined with mechanical and metabolic factors that cause molecular alterations the end results of which affect the whole joint .Glucosamine and chondrotin sulfate alone or in combination may be of benefit to a subgroup of individuals who have knee pain due to OA. Glucosamine has been shown to alter cartiage turn over in patients with OA undergoing physical training Aim of the study: To find the validity of glucosamine chondrotin sulfate in treatment of grade 1 and 2 OA. Methods: the sample of 280 patients (418 knee) were divided in to two groups , group A (132 patient) treated by classical methods by glucosamine chondrotin sulfate for one year. For both groups different parameters were used including pain stiffness effusion crepitus and genu varum and different radiological findings and we used MRI for evaluation pre and post treatment Result: Female/ male ratio was 2.89 the highest age group was ( 60-69) year regarding the clinical presentation of patients the commonest clinical presentation were pain and stiffness and the MRI finding including bone marrow edema shows good indicator for response to treatment . Conclusion: Pain ,stiffness and crepitus were common presentation of OARelief of pain andstiffness were related to decrease of effusion and bone marrow edema which is the result of using nonsteroidal anti-inflammatory drugs with glucosamine chondroitin sulfate more than when non steroidal anti- inflammatory drugs alone. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/561Osteoarthritis-glucosamine chondroitin sulfate |
| spellingShingle | Sadeq A. AlMukhtar Sinan Al-Muktar The Role of Glucosamine Chondrotin Sulfate in the Treatment of Osteoarthritis of Knee مجله كليه طب الكندي Osteoarthritis- glucosamine chondroitin sulfate |
| title | The Role of Glucosamine Chondrotin Sulfate in the Treatment of Osteoarthritis of Knee |
| title_full | The Role of Glucosamine Chondrotin Sulfate in the Treatment of Osteoarthritis of Knee |
| title_fullStr | The Role of Glucosamine Chondrotin Sulfate in the Treatment of Osteoarthritis of Knee |
| title_full_unstemmed | The Role of Glucosamine Chondrotin Sulfate in the Treatment of Osteoarthritis of Knee |
| title_short | The Role of Glucosamine Chondrotin Sulfate in the Treatment of Osteoarthritis of Knee |
| title_sort | role of glucosamine chondrotin sulfate in the treatment of osteoarthritis of knee |
| topic | Osteoarthritis- glucosamine chondroitin sulfate |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/561 |
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