Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly into new variants throughout the pandemic. The Omicron variant has more than 50 mutations when compared with the original wild-type strain and has been identified globally in numerous countries. In this report, we a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-06-01
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| Series: | Journal of Biosafety and Biosecurity |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2588933821000558 |
| _version_ | 1818533872325885952 |
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| author | Yamin Sun Wenchao Lin Wei Dong Jianguo Xu |
| author_facet | Yamin Sun Wenchao Lin Wei Dong Jianguo Xu |
| author_sort | Yamin Sun |
| collection | DOAJ |
| description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly into new variants throughout the pandemic. The Omicron variant has more than 50 mutations when compared with the original wild-type strain and has been identified globally in numerous countries. In this report, we analyzed the mutational profiles of several variants, including the per-site mutation rate, to determine evolutionary relationships. The Omicron variant was found to have a unique mutation profile when compared with that of other SARS-CoV-2 variants, containing mutations that are rare in clinical samples. Moreover, the presence of five mouse-adapted mutation sites suggests that Omicron may have evolved in a mouse host. Mutations in the Omicron receptor-binding domain (RBD) region, in particular, have potential implications for the ongoing pandemic. |
| first_indexed | 2024-12-11T18:04:27Z |
| format | Article |
| id | doaj.art-f59df94a9b32457dadc3a0d0e59fe608 |
| institution | Directory Open Access Journal |
| issn | 2588-9338 |
| language | English |
| last_indexed | 2024-12-11T18:04:27Z |
| publishDate | 2022-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Biosafety and Biosecurity |
| spelling | doaj.art-f59df94a9b32457dadc3a0d0e59fe6082022-12-22T00:55:47ZengKeAi Communications Co., Ltd.Journal of Biosafety and Biosecurity2588-93382022-06-01413337Origin and evolutionary analysis of the SARS-CoV-2 Omicron variantYamin Sun0Wenchao Lin1Wei Dong2Jianguo Xu3Research Institute of Public Health, Nankai University, Tianjin, PR China; Engineering and Research Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Nankai UniversityEngineering and Research Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Nankai UniversityEngineering and Research Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Nankai UniversityResearch Institute of Public Health, Nankai University, Tianjin, PR China; State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China; Corresponding author.The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly into new variants throughout the pandemic. The Omicron variant has more than 50 mutations when compared with the original wild-type strain and has been identified globally in numerous countries. In this report, we analyzed the mutational profiles of several variants, including the per-site mutation rate, to determine evolutionary relationships. The Omicron variant was found to have a unique mutation profile when compared with that of other SARS-CoV-2 variants, containing mutations that are rare in clinical samples. Moreover, the presence of five mouse-adapted mutation sites suggests that Omicron may have evolved in a mouse host. Mutations in the Omicron receptor-binding domain (RBD) region, in particular, have potential implications for the ongoing pandemic.http://www.sciencedirect.com/science/article/pii/S2588933821000558SARS-CoV-2Omicron variantMouse-adapted mutationReverse zoonosis |
| spellingShingle | Yamin Sun Wenchao Lin Wei Dong Jianguo Xu Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant Journal of Biosafety and Biosecurity SARS-CoV-2 Omicron variant Mouse-adapted mutation Reverse zoonosis |
| title | Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant |
| title_full | Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant |
| title_fullStr | Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant |
| title_full_unstemmed | Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant |
| title_short | Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant |
| title_sort | origin and evolutionary analysis of the sars cov 2 omicron variant |
| topic | SARS-CoV-2 Omicron variant Mouse-adapted mutation Reverse zoonosis |
| url | http://www.sciencedirect.com/science/article/pii/S2588933821000558 |
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