Functional Gastrointestinal Disorders in Patients with Inflammatory Bowel Disease
With emerging more effective drugs, the therapeutic goal of inflammatory bowel disease (IBD) has progressed from clinical remission to mucosal healing. Although the inflammation could be controlled more effectively than before, symptoms such as abdominal pain and bowel habit change is still bother...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Jin Publishing & Printing Co.
2022-01-01
|
| Series: | The Korean Journal of Gastroenterology |
| Subjects: | |
| Online Access: | https://www.kjg.or.kr/journal/view.html?uid=5782&vmd=Full |
| Summary: | With emerging more effective drugs, the therapeutic goal of inflammatory bowel disease (IBD) has progressed from clinical remission
to mucosal healing. Although the inflammation could be controlled more effectively than before, symptoms such as abdominal pain
and bowel habit change is still bothersome to some IBD patients. Recently, these “refractory functional gastrointestinal symptoms”
in quiescent IBD patients has been paid more attention. The pathophysiology could be multifactorial with genetics, change in gut
motility associated with post inflammatory condition, increased permeability, impaired colorectal function, visceral hypersensitivity
and gut microbiota. Because both IBD and functional gastrointestinal disease (FGID) could share similar symptoms and some pathophysiology,
it is sometimes challenging to distinguish them exactly. However, to reduce the risk of overtreatment or insufficient control
of inflammation, exact diagnosis of functional disease or symptoms in quiescent IBD patients is important. Because there is limited
randomized controlled trials or prospective study currently, most of the therapeutic approach in IBD patients are empirical or referred
to those of functional gastrointestinal disorders. However, approaches based on pathophysiological mechanisms could give appropriate
therapies for both IBD and FGIDs. |
|---|---|
| ISSN: | 1598-9992 2233-6869 |