Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions
Myricetin, a flavonoid found in the plant kingdom, has previously been identified as a food molecule with beneficial effects against obesity. This property has been related with its potential to inhibit lipase, the enzyme responsible for fat digestion. In this study, we investigate the interaction b...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/9/6/777 |
| _version_ | 1797565608369324032 |
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| author | Atma-Sol Bustos Andreas Håkansson Javier A. Linares-Pastén Lars Nilsson |
| author_facet | Atma-Sol Bustos Andreas Håkansson Javier A. Linares-Pastén Lars Nilsson |
| author_sort | Atma-Sol Bustos |
| collection | DOAJ |
| description | Myricetin, a flavonoid found in the plant kingdom, has previously been identified as a food molecule with beneficial effects against obesity. This property has been related with its potential to inhibit lipase, the enzyme responsible for fat digestion. In this study, we investigate the interaction between myricetin and lipase under simplified intestinal conditions from a colloidal point of view. The results show that myricetin form aggregates in aqueous medium and under simplified intestinal condition, where it was found that lipase is in its monomeric form. Although lipase inhibition by myricetin at a molecular level has been reported previously, the results of this study suggest that myricetin aggregates inhibit lipase by a sequestering mechanism as well. The size of these aggregates was determined to be in the range of a few nm to >200 nm. |
| first_indexed | 2024-03-10T19:14:36Z |
| format | Article |
| id | doaj.art-f59f92a715444effb8f40fb89a26f37a |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T19:14:36Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-f59f92a715444effb8f40fb89a26f37a2023-11-20T03:33:21ZengMDPI AGFoods2304-81582020-06-019677710.3390/foods9060777Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal ConditionsAtma-Sol Bustos0Andreas Håkansson1Javier A. Linares-Pastén2Lars Nilsson3Food Technology, Faculty of Engineering LTH, Lund University, PO Box 124, S-221 00 Lund, SwedenFood Technology, Faculty of Engineering LTH, Lund University, PO Box 124, S-221 00 Lund, SwedenBiotechnology, Faculty of Engineering LTH, Lund University, PO Box 117, S-221 00 Lund, SwedenFood Technology, Faculty of Engineering LTH, Lund University, PO Box 124, S-221 00 Lund, SwedenMyricetin, a flavonoid found in the plant kingdom, has previously been identified as a food molecule with beneficial effects against obesity. This property has been related with its potential to inhibit lipase, the enzyme responsible for fat digestion. In this study, we investigate the interaction between myricetin and lipase under simplified intestinal conditions from a colloidal point of view. The results show that myricetin form aggregates in aqueous medium and under simplified intestinal condition, where it was found that lipase is in its monomeric form. Although lipase inhibition by myricetin at a molecular level has been reported previously, the results of this study suggest that myricetin aggregates inhibit lipase by a sequestering mechanism as well. The size of these aggregates was determined to be in the range of a few nm to >200 nm.https://www.mdpi.com/2304-8158/9/6/777myricetin aggregateslipase inhibitionintestinal conditionssequestering mechanism |
| spellingShingle | Atma-Sol Bustos Andreas Håkansson Javier A. Linares-Pastén Lars Nilsson Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions Foods myricetin aggregates lipase inhibition intestinal conditions sequestering mechanism |
| title | Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions |
| title_full | Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions |
| title_fullStr | Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions |
| title_full_unstemmed | Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions |
| title_short | Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions |
| title_sort | interaction between myricetin aggregates and lipase under simplified intestinal conditions |
| topic | myricetin aggregates lipase inhibition intestinal conditions sequestering mechanism |
| url | https://www.mdpi.com/2304-8158/9/6/777 |
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