Gain a Baby Lose a Tooth—Is There an Association between Periodontitis and Preterm Birth?
Preterm birth serves as one of the leading causes of neonatal mortality worldwide. The underlying mechanisms that contribute to preterm birth are not yet fully understood. However, an association between periodontitis and preterm birth has been proposed. The periodontal status and presence of period...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/23/7183 |
| _version_ | 1797462903359537152 |
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| author | Valentin Bartha Sahra Steinmacher Rebekka Wittlinger Sébastien Boutin Jan Pauluschke-Fröhlich Christiane von Ohle Sara Yvonne Brucker Thomas Bruckner Diana Wolff |
| author_facet | Valentin Bartha Sahra Steinmacher Rebekka Wittlinger Sébastien Boutin Jan Pauluschke-Fröhlich Christiane von Ohle Sara Yvonne Brucker Thomas Bruckner Diana Wolff |
| author_sort | Valentin Bartha |
| collection | DOAJ |
| description | Preterm birth serves as one of the leading causes of neonatal mortality worldwide. The underlying mechanisms that contribute to preterm birth are not yet fully understood. However, an association between periodontitis and preterm birth has been proposed. The periodontal status and presence of periodontal pathogens in women with different birth outcomes have been previously examined. However, varying definitions of periodontitis and different microbiological methods make their interpretation challenging. The aim of this case-control study on women with and without preterm birth was to investigate their periodontal status using the current classification system for periodontal diseases. Moreover, differences in the periodontal microbiome of the study participants were investigated. Therefore, we collected data on oral and periodontal parameters in 77 puerperal women divided into two groups based on gestational age at delivery: 33 patients with preterm birth (PTB, <37 weeks) and 44 patients with term birth (TB, >37 weeks). These data included pocket probing depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), gingival-bleeding index, DMFT index, and gynecologic and dental history. In addition, their oral microbiome was explored. Median CAL and percentage PPD ≥ 4 mm were significantly higher in the PTB group than in the TB group (<i>p</i> = 0.0128 and <i>p</i> = 0.047, respectively). Birth weight was significantly higher in periodontally healthy women than in those with gingivitis (<i>p</i> = 0.0078) or periodontitis (<i>p</i> = 0.0127). The periodontal microbiome differed significantly between groups. Our results are underlining the possible association between periodontitis and preterm delivery. Women with periodontitis had babies with significantly lower birth weights. The microbiome varied between the groups. |
| first_indexed | 2024-03-09T17:43:07Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T17:43:07Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f59fee44f7304290bde07bda8fc797d82023-11-24T11:24:20ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-011123718310.3390/jcm11237183Gain a Baby Lose a Tooth—Is There an Association between Periodontitis and Preterm Birth?Valentin Bartha0Sahra Steinmacher1Rebekka Wittlinger2Sébastien Boutin3Jan Pauluschke-Fröhlich4Christiane von Ohle5Sara Yvonne Brucker6Thomas Bruckner7Diana Wolff8Department of Restorative Dentistry, Tuebingen University Hospital, Osianderstraße 2, 72076 Tuebingen, GermanyDepartment of Women’s Health, Tuebingen University Hospital, Calwerstr. 7, 72076 Tuebingen, GermanyDepartment of Restorative Dentistry, Tuebingen University Hospital, Osianderstraße 2, 72076 Tuebingen, GermanyCenter for Infectiology, Heidelberg University Hospital, Im Neuenheimer Feld 324, 69120 Heidelberg, GermanyDepartment of Women’s Health, Tuebingen University Hospital, Calwerstr. 7, 72076 Tuebingen, GermanyDepartment of Restorative Dentistry, Tuebingen University Hospital, Osianderstraße 2, 72076 Tuebingen, GermanyDepartment of Women’s Health, Tuebingen University Hospital, Calwerstr. 7, 72076 Tuebingen, GermanyInstitute for Medical Biometry/Biostatistics, Heidelberg University Hospital, Im Neuenheimer Feld 130, 69120 Heidelberg, GermanyCenter for Conservative Dentistry and Periodontology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, GermanyPreterm birth serves as one of the leading causes of neonatal mortality worldwide. The underlying mechanisms that contribute to preterm birth are not yet fully understood. However, an association between periodontitis and preterm birth has been proposed. The periodontal status and presence of periodontal pathogens in women with different birth outcomes have been previously examined. However, varying definitions of periodontitis and different microbiological methods make their interpretation challenging. The aim of this case-control study on women with and without preterm birth was to investigate their periodontal status using the current classification system for periodontal diseases. Moreover, differences in the periodontal microbiome of the study participants were investigated. Therefore, we collected data on oral and periodontal parameters in 77 puerperal women divided into two groups based on gestational age at delivery: 33 patients with preterm birth (PTB, <37 weeks) and 44 patients with term birth (TB, >37 weeks). These data included pocket probing depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), gingival-bleeding index, DMFT index, and gynecologic and dental history. In addition, their oral microbiome was explored. Median CAL and percentage PPD ≥ 4 mm were significantly higher in the PTB group than in the TB group (<i>p</i> = 0.0128 and <i>p</i> = 0.047, respectively). Birth weight was significantly higher in periodontally healthy women than in those with gingivitis (<i>p</i> = 0.0078) or periodontitis (<i>p</i> = 0.0127). The periodontal microbiome differed significantly between groups. Our results are underlining the possible association between periodontitis and preterm delivery. Women with periodontitis had babies with significantly lower birth weights. The microbiome varied between the groups.https://www.mdpi.com/2077-0383/11/23/7183periodontitispreterm birthoral microbiome16S rRNA sequencing |
| spellingShingle | Valentin Bartha Sahra Steinmacher Rebekka Wittlinger Sébastien Boutin Jan Pauluschke-Fröhlich Christiane von Ohle Sara Yvonne Brucker Thomas Bruckner Diana Wolff Gain a Baby Lose a Tooth—Is There an Association between Periodontitis and Preterm Birth? Journal of Clinical Medicine periodontitis preterm birth oral microbiome 16S rRNA sequencing |
| title | Gain a Baby Lose a Tooth—Is There an Association between Periodontitis and Preterm Birth? |
| title_full | Gain a Baby Lose a Tooth—Is There an Association between Periodontitis and Preterm Birth? |
| title_fullStr | Gain a Baby Lose a Tooth—Is There an Association between Periodontitis and Preterm Birth? |
| title_full_unstemmed | Gain a Baby Lose a Tooth—Is There an Association between Periodontitis and Preterm Birth? |
| title_short | Gain a Baby Lose a Tooth—Is There an Association between Periodontitis and Preterm Birth? |
| title_sort | gain a baby lose a tooth is there an association between periodontitis and preterm birth |
| topic | periodontitis preterm birth oral microbiome 16S rRNA sequencing |
| url | https://www.mdpi.com/2077-0383/11/23/7183 |
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