Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons

Summary: Parkinson’s disease (PD) is characterized by a progressive deterioration of motor and cognitive functions. Although death of dopamine neurons is the hallmark pathology of PD, this is a late-stage disease process preceded by neuronal dysfunction. Here we describe early physiological perturba...

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Bibliographic Details
Main Authors: Dayne A. Beccano-Kelly, Marta Cherubini, Yassine Mousba, Kaitlyn M.L. Cramb, Stefania Giussani, Maria Claudia Caiazza, Pavandeep Rai, Siv Vingill, Nora Bengoa-Vergniory, Bryan Ng, Gabriele Corda, Abhirup Banerjee, Jane Vowles, Sally Cowley, Richard Wade-Martins
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Pathophysiology
Cellular neuroscience
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223011215

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