Osteonectin bidirectionally regulates osteoblast mineralization

Osteonectin bidirectionally regulates osteoblast mineralization

Abstract Objective The aim of this study was to investigate whether Osteonectin/Secreted protein acidic and rich in cysteine (ON/SPARC) had a two-way dose-dependent regulatory effect on osteoblast mineralization and its molecular mechanism. Methods Initially, different concentrations of ON were adde...

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Bibliographic Details
Main Authors:	Yun‑Sen Zhu, Ting‑Ting Mo, Chang Jiang, Jiang‑Nan Zhang
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Series:	Journal of Orthopaedic Surgery and Research
Subjects:	Osteonectin p38 MAPK signaling pathway Discoidin domain receptor 2 Mineralization
Online Access:	https://doi.org/10.1186/s13018-023-04250-1

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