Is antibiotic prophylaxis still mandatory for transperineal prostate biopsy? Results of a comparative study
Introduction and objectives: This study aimed to assess the incidence of urinary tract infections (UTIs) after transperineal prostate biopsy (TP-PB) comparing patients who underwent antibiotic prophylaxis (AP) with patients who had no prophylaxis. Materials and methods: This prospective, double-cent...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-03-01
|
| Series: | Prostate International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2287888221000593 |
| _version_ | 1797716222103519232 |
|---|---|
| author | Giacomo M. Pirola Marilena Gubbiotti Emanuele Rubilotta Daniele Castellani Nicolò Trabacchin Alessandro Tafuri Alessandro Princiotta Eugenio Martorana Filippo Annino Alessandro Antonelli |
| author_facet | Giacomo M. Pirola Marilena Gubbiotti Emanuele Rubilotta Daniele Castellani Nicolò Trabacchin Alessandro Tafuri Alessandro Princiotta Eugenio Martorana Filippo Annino Alessandro Antonelli |
| author_sort | Giacomo M. Pirola |
| collection | DOAJ |
| description | Introduction and objectives: This study aimed to assess the incidence of urinary tract infections (UTIs) after transperineal prostate biopsy (TP-PB) comparing patients who underwent antibiotic prophylaxis (AP) with patients who had no prophylaxis. Materials and methods: This prospective, double-center trial was conducted between August and December 2020. Patient candidates to PB were included with 1:1 allocation to case (Group A-no AP) and control group (Group B-standard AP). All TP-PBs were performed in an outpatient setting under local anesthesia. Data collected 2 weeks after the procedure included incidence of UTIs or bacteriuria, evaluated with a urine culture (UC), main symptoms, and complications related to TP-PBs. Results: A total of 200 patients were included (100 patients in each group). The mean age was 66.2 ± 7.7 in Group A and 67.4 ± 8 years in Group B (P = 0.134). Mean prostate volume was 65.5 ± 26.7 vs. 51 ± 24.6 cc (P < 0.001), number of biopsy cores was 17.8 ± 2.4 vs. 14.9 ± 0.8 (P < 0.001), and PSA value was 15.9 ± 28.1 vs. 13.3 ± 22.3 ng/ml (P = 0.017). Overall PCa detection rate was 55% vs. 59% (P = 0.567). Postoperative UTI occurred in one patient in Group A vs. zero in Group B. Asymptomatic bacteriuria was present in 3 vs. 5 patients (P = 0.470) and was not treated with antibiotics. Postoperative hematuria was observed in 13 patients vs. 29 (P < 0.05), and acute urinary retention was observed in one patient in each group. Conclusions: The incidence of bacteriuria and UTIs in TP-PBs is not related to AP. Therefore, AP could be discontinued in TP-PB candidates without the risk of increasing UTI-related complications. |
| first_indexed | 2024-03-12T08:18:21Z |
| format | Article |
| id | doaj.art-f5a11bc35111485b92dccd09cb02c30a |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T08:18:21Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-f5a11bc35111485b92dccd09cb02c30a2023-09-02T18:42:01ZengElsevierProstate International2287-88822022-03-011013437Is antibiotic prophylaxis still mandatory for transperineal prostate biopsy? Results of a comparative studyGiacomo M. Pirola0Marilena Gubbiotti1Emanuele Rubilotta2Daniele Castellani3Nicolò Trabacchin4Alessandro Tafuri5Alessandro Princiotta6Eugenio Martorana7Filippo Annino8Alessandro Antonelli9Department of Urology, Usl Toscana Sud Est, San Donato Hospital, Arezzo, Italy; Corresponding author. Department of Urology, Usl Toscana Sud Est, San Donato Hospital, Arezzo, Italy.Department of Urology, Usl Toscana Sud Est, San Donato Hospital, Arezzo, ItalyDepartment of Urology, A.O.U.I. University of Verona, Verona, ItalyDepartment of Urology, Ospedali Riuniti di Ancona, Le Marche Polytechnic University, Ancona, ItalyDepartment of Urology, A.O.U.I. University of Verona, Verona, ItalyDepartment of Urology, A.O.U.I. University of Verona, Verona, ItalyDepartment of Urology, A.O.U.I. University of Verona, Verona, ItalyDepartment of Urology, Sassuolo Hospital, Sassuolo, ItalyDepartment of Urology, Usl Toscana Sud Est, San Donato Hospital, Arezzo, ItalyDepartment of Urology, A.O.U.I. University of Verona, Verona, ItalyIntroduction and objectives: This study aimed to assess the incidence of urinary tract infections (UTIs) after transperineal prostate biopsy (TP-PB) comparing patients who underwent antibiotic prophylaxis (AP) with patients who had no prophylaxis. Materials and methods: This prospective, double-center trial was conducted between August and December 2020. Patient candidates to PB were included with 1:1 allocation to case (Group A-no AP) and control group (Group B-standard AP). All TP-PBs were performed in an outpatient setting under local anesthesia. Data collected 2 weeks after the procedure included incidence of UTIs or bacteriuria, evaluated with a urine culture (UC), main symptoms, and complications related to TP-PBs. Results: A total of 200 patients were included (100 patients in each group). The mean age was 66.2 ± 7.7 in Group A and 67.4 ± 8 years in Group B (P = 0.134). Mean prostate volume was 65.5 ± 26.7 vs. 51 ± 24.6 cc (P < 0.001), number of biopsy cores was 17.8 ± 2.4 vs. 14.9 ± 0.8 (P < 0.001), and PSA value was 15.9 ± 28.1 vs. 13.3 ± 22.3 ng/ml (P = 0.017). Overall PCa detection rate was 55% vs. 59% (P = 0.567). Postoperative UTI occurred in one patient in Group A vs. zero in Group B. Asymptomatic bacteriuria was present in 3 vs. 5 patients (P = 0.470) and was not treated with antibiotics. Postoperative hematuria was observed in 13 patients vs. 29 (P < 0.05), and acute urinary retention was observed in one patient in each group. Conclusions: The incidence of bacteriuria and UTIs in TP-PBs is not related to AP. Therefore, AP could be discontinued in TP-PB candidates without the risk of increasing UTI-related complications.http://www.sciencedirect.com/science/article/pii/S2287888221000593Antibiotic prophylaxisProstate biopsyProstate cancer screeningTransperineal |
| spellingShingle | Giacomo M. Pirola Marilena Gubbiotti Emanuele Rubilotta Daniele Castellani Nicolò Trabacchin Alessandro Tafuri Alessandro Princiotta Eugenio Martorana Filippo Annino Alessandro Antonelli Is antibiotic prophylaxis still mandatory for transperineal prostate biopsy? Results of a comparative study Prostate International Antibiotic prophylaxis Prostate biopsy Prostate cancer screening Transperineal |
| title | Is antibiotic prophylaxis still mandatory for transperineal prostate biopsy? Results of a comparative study |
| title_full | Is antibiotic prophylaxis still mandatory for transperineal prostate biopsy? Results of a comparative study |
| title_fullStr | Is antibiotic prophylaxis still mandatory for transperineal prostate biopsy? Results of a comparative study |
| title_full_unstemmed | Is antibiotic prophylaxis still mandatory for transperineal prostate biopsy? Results of a comparative study |
| title_short | Is antibiotic prophylaxis still mandatory for transperineal prostate biopsy? Results of a comparative study |
| title_sort | is antibiotic prophylaxis still mandatory for transperineal prostate biopsy results of a comparative study |
| topic | Antibiotic prophylaxis Prostate biopsy Prostate cancer screening Transperineal |
| url | http://www.sciencedirect.com/science/article/pii/S2287888221000593 |
| work_keys_str_mv | AT giacomompirola isantibioticprophylaxisstillmandatoryfortransperinealprostatebiopsyresultsofacomparativestudy AT marilenagubbiotti isantibioticprophylaxisstillmandatoryfortransperinealprostatebiopsyresultsofacomparativestudy AT emanuelerubilotta isantibioticprophylaxisstillmandatoryfortransperinealprostatebiopsyresultsofacomparativestudy AT danielecastellani isantibioticprophylaxisstillmandatoryfortransperinealprostatebiopsyresultsofacomparativestudy AT nicolotrabacchin isantibioticprophylaxisstillmandatoryfortransperinealprostatebiopsyresultsofacomparativestudy AT alessandrotafuri isantibioticprophylaxisstillmandatoryfortransperinealprostatebiopsyresultsofacomparativestudy AT alessandroprinciotta isantibioticprophylaxisstillmandatoryfortransperinealprostatebiopsyresultsofacomparativestudy AT eugeniomartorana isantibioticprophylaxisstillmandatoryfortransperinealprostatebiopsyresultsofacomparativestudy AT filippoannino isantibioticprophylaxisstillmandatoryfortransperinealprostatebiopsyresultsofacomparativestudy AT alessandroantonelli isantibioticprophylaxisstillmandatoryfortransperinealprostatebiopsyresultsofacomparativestudy |