Two new sphingolipids from the stem bark of Synsepalum msolo (Sapotaceae)
Synsepalum msolo commonly known as Bang Bali in Bali-Nguemba, Cameroon is used in traditional medicine against various diseases. The leaves and stem bark extracts were subjected to silica gel and Sephadex LH20 column chromatography to yield pure compounds. The structures of the compounds were determ...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Biochemistry and Biophysics Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580821001096 |
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| author | Ache Roland Ndifor Njinga Ngaitad Stanislaus Chi Godloves Fru Ferdinand Talontsi Turibio Kuiate Tabopda Elisabeth Zeuko'o Menkem Ngadjui Bonaventure Tchaleu Yeboah Samuel Owusu |
| author_facet | Ache Roland Ndifor Njinga Ngaitad Stanislaus Chi Godloves Fru Ferdinand Talontsi Turibio Kuiate Tabopda Elisabeth Zeuko'o Menkem Ngadjui Bonaventure Tchaleu Yeboah Samuel Owusu |
| author_sort | Ache Roland Ndifor |
| collection | DOAJ |
| description | Synsepalum msolo commonly known as Bang Bali in Bali-Nguemba, Cameroon is used in traditional medicine against various diseases. The leaves and stem bark extracts were subjected to silica gel and Sephadex LH20 column chromatography to yield pure compounds. The structures of the compounds were determined by detail analysis of NMR and Mass spectroscopic data and by comparison with data reported in the literature. Amongst the isolates, were two new sphingolipids: synsepaloside B (1), synsepaloside C (2), and five known compounds: (+)-catechin (3), (−)-epicatechin (4), myricitrin (5), triacontanol (6), and aurantiamide acetate (7). Compounds 1–5 were screened for their antibacterial and anti-yeast activities on several microorganisms. All the tested compounds exhibited weak antibacterial (MIC ≥ 200 μg/mL) and anti-yeast (MIC > 200 μg/mL) activities as compared to standard: ciprofloxacin 0.468 < MIC >0.234 μg/mL and fluconazole MIC = 0.05 μg/mL, respectively. |
| first_indexed | 2024-12-13T20:19:43Z |
| format | Article |
| id | doaj.art-f5a5a3893ed045009368079f89c65e83 |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-12-13T20:19:43Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-f5a5a3893ed045009368079f89c65e832022-12-21T23:32:44ZengElsevierBiochemistry and Biophysics Reports2405-58082021-09-0127101014Two new sphingolipids from the stem bark of Synsepalum msolo (Sapotaceae)Ache Roland Ndifor0Njinga Ngaitad Stanislaus1Chi Godloves Fru2Ferdinand Talontsi3Turibio Kuiate Tabopda4Elisabeth Zeuko'o Menkem5Ngadjui Bonaventure Tchaleu6Yeboah Samuel Owusu7Higher Technical Teacher Training College, University of Bamenda, Cameroon; Corresponding author.Department of Pharmaceutical and Medicinal Chemistry, University of Ilorin, Ilorin, NigeriaDepartment of Organic Chemistry, Faculty of Science, University of Yaounde I, CameroonInstitute of Environmental Research (INFU), Faculty of Chemistry, TU Dortmund, Otto-Hahn-Str, 644221, Dortmund, GermanyDepartment of Organic Chemistry, Faculty of Science, University of Yaounde I, CameroonDepartment of Biochemistry, Faculty of Science, University of Yaounde I, CameroonDepartment of Organic Chemistry, Faculty of Science, University of Yaounde I, CameroonDepartment of Chemistry, University of Botswana, Gaborone, BotswanaSynsepalum msolo commonly known as Bang Bali in Bali-Nguemba, Cameroon is used in traditional medicine against various diseases. The leaves and stem bark extracts were subjected to silica gel and Sephadex LH20 column chromatography to yield pure compounds. The structures of the compounds were determined by detail analysis of NMR and Mass spectroscopic data and by comparison with data reported in the literature. Amongst the isolates, were two new sphingolipids: synsepaloside B (1), synsepaloside C (2), and five known compounds: (+)-catechin (3), (−)-epicatechin (4), myricitrin (5), triacontanol (6), and aurantiamide acetate (7). Compounds 1–5 were screened for their antibacterial and anti-yeast activities on several microorganisms. All the tested compounds exhibited weak antibacterial (MIC ≥ 200 μg/mL) and anti-yeast (MIC > 200 μg/mL) activities as compared to standard: ciprofloxacin 0.468 < MIC >0.234 μg/mL and fluconazole MIC = 0.05 μg/mL, respectively.http://www.sciencedirect.com/science/article/pii/S2405580821001096SapotaceaeSynsepalum msoloPhytoconstituentsAntibacterialAntifungal |
| spellingShingle | Ache Roland Ndifor Njinga Ngaitad Stanislaus Chi Godloves Fru Ferdinand Talontsi Turibio Kuiate Tabopda Elisabeth Zeuko'o Menkem Ngadjui Bonaventure Tchaleu Yeboah Samuel Owusu Two new sphingolipids from the stem bark of Synsepalum msolo (Sapotaceae) Biochemistry and Biophysics Reports Sapotaceae Synsepalum msolo Phytoconstituents Antibacterial Antifungal |
| title | Two new sphingolipids from the stem bark of Synsepalum msolo (Sapotaceae) |
| title_full | Two new sphingolipids from the stem bark of Synsepalum msolo (Sapotaceae) |
| title_fullStr | Two new sphingolipids from the stem bark of Synsepalum msolo (Sapotaceae) |
| title_full_unstemmed | Two new sphingolipids from the stem bark of Synsepalum msolo (Sapotaceae) |
| title_short | Two new sphingolipids from the stem bark of Synsepalum msolo (Sapotaceae) |
| title_sort | two new sphingolipids from the stem bark of synsepalum msolo sapotaceae |
| topic | Sapotaceae Synsepalum msolo Phytoconstituents Antibacterial Antifungal |
| url | http://www.sciencedirect.com/science/article/pii/S2405580821001096 |
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