Dissection of the amyloid formation pathway in AL amyloidosis
AL amyloidosis is caused by the accumulation of overproduced light chain (LC) fragments as fibrils in patient organs and it is the most prevalent systemic amyloidosis. Here, the authors combine biochemical and biophysical experiments to characterise the lag phase of a patient-derived truncated LC an...
Main Authors: | Pamina Kazman, Ramona M. Absmeier, Harald Engelhardt, Johannes Buchner |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2021-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-26845-0 |
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