The LAUsanne STAPHylococcus aureus ENdocarditis (LAUSTAPHEN) score: A prediction score to estimate initial risk for infective endocarditis in patients with S. aureus bacteremia
IntroductionInfective endocarditis (IE) is a common complication of Staphylococcus aureus bacteremia (SAB). The study aimed to develop and validate a prediction score to determine IE risk among SAB.MethodsThis retrospective study included adults with SAB (2015–2021) and divided them into derivation...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.961579/full |
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| author | Matthaios Papadimitriou-Olivgeris Matthaios Papadimitriou-Olivgeris Pierre Monney Linda Mueller Laurence Senn Laurence Senn Benoit Guery |
| author_facet | Matthaios Papadimitriou-Olivgeris Matthaios Papadimitriou-Olivgeris Pierre Monney Linda Mueller Laurence Senn Laurence Senn Benoit Guery |
| author_sort | Matthaios Papadimitriou-Olivgeris |
| collection | DOAJ |
| description | IntroductionInfective endocarditis (IE) is a common complication of Staphylococcus aureus bacteremia (SAB). The study aimed to develop and validate a prediction score to determine IE risk among SAB.MethodsThis retrospective study included adults with SAB (2015–2021) and divided them into derivation and validation cohorts. Using the modified 2015 European Society of Cardiology modified Duke Criteria for definite IE, the LAUSTAPHEN score was compared to previous scores.ResultsAmong 821 SAB episodes, 419 and 402 were divided into derivation and validation cohorts, respectively. Transthoracic and transoesophageal echocardiography (TOE) were performed in 77.5 and 42.1% of episodes, respectively. Definite IE was diagnosed in 118 episodes (14.4%). Derivation cohort established that cardiac predisposing factors, such as cardiac implantable electronic devices, prolonged bacteremia ≥48 h, and vascular phenomena were independently associated with IE. In addition to those parameters, native bone and joint infections were used to constitute the LAUSTAPHEN score. LAUSTAPHEN and VIRSTA scores misclassified <4% of IE cases as low risk. Misclassification using POSITIVE and PREDICT scores was >10%. The number of TOEs required to safely exclude IE were 66.9 and 51.6% with VIRSTA and LAUSTAPHEN, respectively.DiscussionLAUSTAPHEN and VIRSTA scores exhibited the lowest misclassification rate of IE cases to the low-risk group. However, the number of patients requiring TOE was higher for VIRSTA than for LAUSTAPHEN. |
| first_indexed | 2024-04-10T05:40:32Z |
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| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T05:40:32Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-f5aad055305446a3aa57f72524ca99a72023-03-06T11:51:08ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-12-01910.3389/fcvm.2022.961579961579The LAUsanne STAPHylococcus aureus ENdocarditis (LAUSTAPHEN) score: A prediction score to estimate initial risk for infective endocarditis in patients with S. aureus bacteremiaMatthaios Papadimitriou-Olivgeris0Matthaios Papadimitriou-Olivgeris1Pierre Monney2Linda Mueller3Laurence Senn4Laurence Senn5Benoit Guery6Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandInfection Prevention and Control Unit, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDepartment of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandInstitute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandInfectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandInfection Prevention and Control Unit, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandInfectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandIntroductionInfective endocarditis (IE) is a common complication of Staphylococcus aureus bacteremia (SAB). The study aimed to develop and validate a prediction score to determine IE risk among SAB.MethodsThis retrospective study included adults with SAB (2015–2021) and divided them into derivation and validation cohorts. Using the modified 2015 European Society of Cardiology modified Duke Criteria for definite IE, the LAUSTAPHEN score was compared to previous scores.ResultsAmong 821 SAB episodes, 419 and 402 were divided into derivation and validation cohorts, respectively. Transthoracic and transoesophageal echocardiography (TOE) were performed in 77.5 and 42.1% of episodes, respectively. Definite IE was diagnosed in 118 episodes (14.4%). Derivation cohort established that cardiac predisposing factors, such as cardiac implantable electronic devices, prolonged bacteremia ≥48 h, and vascular phenomena were independently associated with IE. In addition to those parameters, native bone and joint infections were used to constitute the LAUSTAPHEN score. LAUSTAPHEN and VIRSTA scores misclassified <4% of IE cases as low risk. Misclassification using POSITIVE and PREDICT scores was >10%. The number of TOEs required to safely exclude IE were 66.9 and 51.6% with VIRSTA and LAUSTAPHEN, respectively.DiscussionLAUSTAPHEN and VIRSTA scores exhibited the lowest misclassification rate of IE cases to the low-risk group. However, the number of patients requiring TOE was higher for VIRSTA than for LAUSTAPHEN.https://www.frontiersin.org/articles/10.3389/fcvm.2022.961579/fullStaphylococcus aureus bacteraemiainfective endocarditistransoesophageal echocardiography (TOE)bloodstream infectionrisk stratification |
| spellingShingle | Matthaios Papadimitriou-Olivgeris Matthaios Papadimitriou-Olivgeris Pierre Monney Linda Mueller Laurence Senn Laurence Senn Benoit Guery The LAUsanne STAPHylococcus aureus ENdocarditis (LAUSTAPHEN) score: A prediction score to estimate initial risk for infective endocarditis in patients with S. aureus bacteremia Frontiers in Cardiovascular Medicine Staphylococcus aureus bacteraemia infective endocarditis transoesophageal echocardiography (TOE) bloodstream infection risk stratification |
| title | The LAUsanne STAPHylococcus aureus ENdocarditis (LAUSTAPHEN) score: A prediction score to estimate initial risk for infective endocarditis in patients with S. aureus bacteremia |
| title_full | The LAUsanne STAPHylococcus aureus ENdocarditis (LAUSTAPHEN) score: A prediction score to estimate initial risk for infective endocarditis in patients with S. aureus bacteremia |
| title_fullStr | The LAUsanne STAPHylococcus aureus ENdocarditis (LAUSTAPHEN) score: A prediction score to estimate initial risk for infective endocarditis in patients with S. aureus bacteremia |
| title_full_unstemmed | The LAUsanne STAPHylococcus aureus ENdocarditis (LAUSTAPHEN) score: A prediction score to estimate initial risk for infective endocarditis in patients with S. aureus bacteremia |
| title_short | The LAUsanne STAPHylococcus aureus ENdocarditis (LAUSTAPHEN) score: A prediction score to estimate initial risk for infective endocarditis in patients with S. aureus bacteremia |
| title_sort | lausanne staphylococcus aureus endocarditis laustaphen score a prediction score to estimate initial risk for infective endocarditis in patients with s aureus bacteremia |
| topic | Staphylococcus aureus bacteraemia infective endocarditis transoesophageal echocardiography (TOE) bloodstream infection risk stratification |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.961579/full |
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