Value of Area Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies
Objectives: To compare the frequency of area postrema syndrome (APS) in adults with anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies.Methods: APS is defined as acute or subacute, single or combined, episodic or constant nausea, vomiting, or hiccups, persisting fo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-06-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00396/full |
| _version_ | 1818979532127862784 |
|---|---|
| author | Jae-Won Hyun Young Nam Kwon Young Nam Kwon Sung-Min Kim Hye Lim Lee Woo Kyo Jeong Woo Kyo Jeong Hye Jung Lee Hye Jung Lee Byoung Joon Kim Byoung Joon Kim Seung Woo Kim Ha Young Shin Hyun-June Shin Sun-Young Oh So-Young Huh Woojun Kim Min Su Park Jeeyoung Oh Hyunmin Jang Na Young Park Min Young Lee Su-Hyun Kim Ho Jin Kim |
| author_facet | Jae-Won Hyun Young Nam Kwon Young Nam Kwon Sung-Min Kim Hye Lim Lee Woo Kyo Jeong Woo Kyo Jeong Hye Jung Lee Hye Jung Lee Byoung Joon Kim Byoung Joon Kim Seung Woo Kim Ha Young Shin Hyun-June Shin Sun-Young Oh So-Young Huh Woojun Kim Min Su Park Jeeyoung Oh Hyunmin Jang Na Young Park Min Young Lee Su-Hyun Kim Ho Jin Kim |
| author_sort | Jae-Won Hyun |
| collection | DOAJ |
| description | Objectives: To compare the frequency of area postrema syndrome (APS) in adults with anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies.Methods: APS is defined as acute or subacute, single or combined, episodic or constant nausea, vomiting, or hiccups, persisting for at least 48 h, which cannot be attributed to any other etiology. The presence of APS was investigated in 274 adults with AQP4 antibodies and 107 adults with MOG antibodies from 10 hospitals.Results: The study population comprised Korean adults (≥18 years). At the time of disease onset, 14.9% (41/274) adults with AQP4 antibodies had APS, while none of the participants with MOG antibodies developed APS (p < 0.001). During the course of the disease, 17.2% (47/274) adults with AQP4 antibodies had APS in contrast to 1.9% (2/107) adults with MOG antibodies with APS (p < 0.001).Conclusions: APS, one of the core clinical characteristics of individuals with AQP4 antibodies, is an extremely rare manifestation in Korean adults with MOG antibodies. |
| first_indexed | 2024-12-20T17:01:01Z |
| format | Article |
| id | doaj.art-f5afb01148cd463da4544526a8cce1b5 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T17:01:01Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-f5afb01148cd463da4544526a8cce1b52022-12-21T19:32:33ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-06-011110.3389/fneur.2020.00396539282Value of Area Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG AntibodiesJae-Won Hyun0Young Nam Kwon1Young Nam Kwon2Sung-Min Kim3Hye Lim Lee4Woo Kyo Jeong5Woo Kyo Jeong6Hye Jung Lee7Hye Jung Lee8Byoung Joon Kim9Byoung Joon Kim10Seung Woo Kim11Ha Young Shin12Hyun-June Shin13Sun-Young Oh14So-Young Huh15Woojun Kim16Min Su Park17Jeeyoung Oh18Hyunmin Jang19Na Young Park20Min Young Lee21Su-Hyun Kim22Ho Jin Kim23Department of Neurology, National Cancer Center, Goyang, South KoreaDepartment of Neurology, Seoul National University Hospital, Seoul, South KoreaThe Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul, South KoreaDepartment of Neurology, Seoul National University Hospital, Seoul, South KoreaDepartment of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Neurology, Neuroscience Center, Samsung Medical Center, Seoul, South KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Neurology, Neuroscience Center, Samsung Medical Center, Seoul, South KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Neurology, Neuroscience Center, Samsung Medical Center, Seoul, South KoreaDepartment of Neurology, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Neurology, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Neurology, School of Medicine, Chonbuk National University, Jeonju, South KoreaDepartment of Neurology, School of Medicine, Chonbuk National University, Jeonju, South KoreaDepartment of Neurology, Kosin University College of Medicine, Busan, South Korea0Department of Neurology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea1Department of Neurology, Yeungnam University College of Medicine, Daegu, South Korea2Department of Neurology, Konkuk University School of Medicine, Seoul, South KoreaDepartment of Neurology, National Cancer Center, Goyang, South KoreaDepartment of Neurology, National Cancer Center, Goyang, South KoreaDepartment of Neurology, National Cancer Center, Goyang, South KoreaDepartment of Neurology, National Cancer Center, Goyang, South KoreaDepartment of Neurology, National Cancer Center, Goyang, South KoreaObjectives: To compare the frequency of area postrema syndrome (APS) in adults with anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies.Methods: APS is defined as acute or subacute, single or combined, episodic or constant nausea, vomiting, or hiccups, persisting for at least 48 h, which cannot be attributed to any other etiology. The presence of APS was investigated in 274 adults with AQP4 antibodies and 107 adults with MOG antibodies from 10 hospitals.Results: The study population comprised Korean adults (≥18 years). At the time of disease onset, 14.9% (41/274) adults with AQP4 antibodies had APS, while none of the participants with MOG antibodies developed APS (p < 0.001). During the course of the disease, 17.2% (47/274) adults with AQP4 antibodies had APS in contrast to 1.9% (2/107) adults with MOG antibodies with APS (p < 0.001).Conclusions: APS, one of the core clinical characteristics of individuals with AQP4 antibodies, is an extremely rare manifestation in Korean adults with MOG antibodies.https://www.frontiersin.org/article/10.3389/fneur.2020.00396/fullarea postrema syndromeaquaporin-4 antibodyMOG antibodyneuromyelitis optica spectrum disorderdiagnosis |
| spellingShingle | Jae-Won Hyun Young Nam Kwon Young Nam Kwon Sung-Min Kim Hye Lim Lee Woo Kyo Jeong Woo Kyo Jeong Hye Jung Lee Hye Jung Lee Byoung Joon Kim Byoung Joon Kim Seung Woo Kim Ha Young Shin Hyun-June Shin Sun-Young Oh So-Young Huh Woojun Kim Min Su Park Jeeyoung Oh Hyunmin Jang Na Young Park Min Young Lee Su-Hyun Kim Ho Jin Kim Value of Area Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies Frontiers in Neurology area postrema syndrome aquaporin-4 antibody MOG antibody neuromyelitis optica spectrum disorder diagnosis |
| title | Value of Area Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies |
| title_full | Value of Area Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies |
| title_fullStr | Value of Area Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies |
| title_full_unstemmed | Value of Area Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies |
| title_short | Value of Area Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies |
| title_sort | value of area postrema syndrome in differentiating adults with aqp4 vs mog antibodies |
| topic | area postrema syndrome aquaporin-4 antibody MOG antibody neuromyelitis optica spectrum disorder diagnosis |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00396/full |
| work_keys_str_mv | AT jaewonhyun valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT youngnamkwon valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT youngnamkwon valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT sungminkim valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT hyelimlee valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT wookyojeong valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT wookyojeong valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT hyejunglee valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT hyejunglee valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT byoungjoonkim valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT byoungjoonkim valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT seungwookim valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT hayoungshin valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT hyunjuneshin valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT sunyoungoh valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT soyounghuh valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT woojunkim valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT minsupark valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT jeeyoungoh valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT hyunminjang valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT nayoungpark valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT minyounglee valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT suhyunkim valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies AT hojinkim valueofareapostremasyndromeindifferentiatingadultswithaqp4vsmogantibodies |