Circadian oscillator proteins across the kingdoms of life: structural aspects
Abstract Circadian oscillators are networks of biochemical feedback loops that generate 24-hour rhythms in organisms from bacteria to animals. These periodic rhythms result from a complex interplay among clock components that are specific to the organism, but share molecular mechanisms across kingdo...
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | BMC Biology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12915-018-0623-3 |
| _version_ | 1811210666481025024 |
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| author | Reena Saini Mariusz Jaskolski Seth J. Davis |
| author_facet | Reena Saini Mariusz Jaskolski Seth J. Davis |
| author_sort | Reena Saini |
| collection | DOAJ |
| description | Abstract Circadian oscillators are networks of biochemical feedback loops that generate 24-hour rhythms in organisms from bacteria to animals. These periodic rhythms result from a complex interplay among clock components that are specific to the organism, but share molecular mechanisms across kingdoms. A full understanding of these processes requires detailed knowledge, not only of the biochemical properties of clock proteins and their interactions, but also of the three-dimensional structure of clockwork components. Posttranslational modifications and protein–protein interactions have become a recent focus, in particular the complex interactions mediated by the phosphorylation of clock proteins and the formation of multimeric protein complexes that regulate clock genes at transcriptional and translational levels. This review covers the structural aspects of circadian oscillators, and serves as a primer for this exciting realm of structural biology. |
| first_indexed | 2024-04-12T04:59:42Z |
| format | Article |
| id | doaj.art-f5b2dd6f121044efa12aa9050d19965a |
| institution | Directory Open Access Journal |
| issn | 1741-7007 |
| language | English |
| last_indexed | 2024-04-12T04:59:42Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj.art-f5b2dd6f121044efa12aa9050d19965a2022-12-22T03:47:02ZengBMCBMC Biology1741-70072019-02-0117113910.1186/s12915-018-0623-3Circadian oscillator proteins across the kingdoms of life: structural aspectsReena Saini0Mariusz Jaskolski1Seth J. Davis2Center for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of SciencesCenter for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of SciencesMax-Planck-Institut für PflanzenzüchtungsforschungAbstract Circadian oscillators are networks of biochemical feedback loops that generate 24-hour rhythms in organisms from bacteria to animals. These periodic rhythms result from a complex interplay among clock components that are specific to the organism, but share molecular mechanisms across kingdoms. A full understanding of these processes requires detailed knowledge, not only of the biochemical properties of clock proteins and their interactions, but also of the three-dimensional structure of clockwork components. Posttranslational modifications and protein–protein interactions have become a recent focus, in particular the complex interactions mediated by the phosphorylation of clock proteins and the formation of multimeric protein complexes that regulate clock genes at transcriptional and translational levels. This review covers the structural aspects of circadian oscillators, and serves as a primer for this exciting realm of structural biology.http://link.springer.com/article/10.1186/s12915-018-0623-3Circadian rhythmsClock genesFeedback loopsTranscription factorsHomo- and heteroprotein complexesPhosphorylation |
| spellingShingle | Reena Saini Mariusz Jaskolski Seth J. Davis Circadian oscillator proteins across the kingdoms of life: structural aspects BMC Biology Circadian rhythms Clock genes Feedback loops Transcription factors Homo- and heteroprotein complexes Phosphorylation |
| title | Circadian oscillator proteins across the kingdoms of life: structural aspects |
| title_full | Circadian oscillator proteins across the kingdoms of life: structural aspects |
| title_fullStr | Circadian oscillator proteins across the kingdoms of life: structural aspects |
| title_full_unstemmed | Circadian oscillator proteins across the kingdoms of life: structural aspects |
| title_short | Circadian oscillator proteins across the kingdoms of life: structural aspects |
| title_sort | circadian oscillator proteins across the kingdoms of life structural aspects |
| topic | Circadian rhythms Clock genes Feedback loops Transcription factors Homo- and heteroprotein complexes Phosphorylation |
| url | http://link.springer.com/article/10.1186/s12915-018-0623-3 |
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