Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study
Abstract Type 2 diabetic kidney disease (T2DKD) is a common microvascular complication of type 2 diabetes mellitus (T2DM), and its incidence is significantly increasing. Microinflammation plays an important role in the development of T2DKD. Based on this, this study investigated the value of inflamm...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-53567-2 |
| _version_ | 1797274759101153280 |
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| author | Yaxuan Fang Bin Wang Bo Pang Zijun Zhou Yunze Xing Pai Pang Dingyuan Zheng Gang Zhang Bo Yang |
| author_facet | Yaxuan Fang Bin Wang Bo Pang Zijun Zhou Yunze Xing Pai Pang Dingyuan Zheng Gang Zhang Bo Yang |
| author_sort | Yaxuan Fang |
| collection | DOAJ |
| description | Abstract Type 2 diabetic kidney disease (T2DKD) is a common microvascular complication of type 2 diabetes mellitus (T2DM), and its incidence is significantly increasing. Microinflammation plays an important role in the development of T2DKD. Based on this, this study investigated the value of inflammatory markers including neutrophil–lymphocyte ratio (NLR), high-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1) in the prediction of T2DKD. This was a cross-sectional survey study. A total of 90 patients with T2DM, who were hospitalized in the nephrology and endocrinology departments of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from June 2021 to January 2022, were included and divided into three groups (A1, A2, A3) according to the urinary albumin-to-creatinine ratio (UACR). Observe and compare the basic information, clinical and laboratory data, and the inflammatory markers NLR, hs-CRP, MCP-1. Results revealed that high levels of NLR (OR = 6.562, 95% CI 2.060–20.902, P = 0.001) and MCP-1 (OR = 1.060, 95% CI 1.026–1.095, P < 0.001) were risk factors in the development of T2DKD. Receiver operating characteristic curve analysis showed that the area under curve of NLR and MCP-1 in diagnosing T2DKD were 0.760 (95% CI 0.6577–0.863, P < 0.001) and 0.862 (95% CI 0.7787–0.937, P < 0.001). Therefore, the inflammatory markers NLR and MCP-1 are risk factors affecting the development of T2DKD, which of clinical value may be used as novel markers of T2DKD. |
| first_indexed | 2024-03-07T15:03:51Z |
| format | Article |
| id | doaj.art-f5b6422c609f4796be7e700595b60498 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:03:51Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f5b6422c609f4796be7e700595b604982024-03-05T19:02:06ZengNature PortfolioScientific Reports2045-23222024-02-011411810.1038/s41598-024-53567-2Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional studyYaxuan Fang0Bin Wang1Bo Pang2Zijun Zhou3Yunze Xing4Pai Pang5Dingyuan Zheng6Gang Zhang7Bo Yang8Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineDepartment of Endocrinology, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineDepartment of Endocrinology, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineThe Community Health Service Center of Hangzhou Road Street in Tianjin Binhai New AreaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineAbstract Type 2 diabetic kidney disease (T2DKD) is a common microvascular complication of type 2 diabetes mellitus (T2DM), and its incidence is significantly increasing. Microinflammation plays an important role in the development of T2DKD. Based on this, this study investigated the value of inflammatory markers including neutrophil–lymphocyte ratio (NLR), high-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1) in the prediction of T2DKD. This was a cross-sectional survey study. A total of 90 patients with T2DM, who were hospitalized in the nephrology and endocrinology departments of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from June 2021 to January 2022, were included and divided into three groups (A1, A2, A3) according to the urinary albumin-to-creatinine ratio (UACR). Observe and compare the basic information, clinical and laboratory data, and the inflammatory markers NLR, hs-CRP, MCP-1. Results revealed that high levels of NLR (OR = 6.562, 95% CI 2.060–20.902, P = 0.001) and MCP-1 (OR = 1.060, 95% CI 1.026–1.095, P < 0.001) were risk factors in the development of T2DKD. Receiver operating characteristic curve analysis showed that the area under curve of NLR and MCP-1 in diagnosing T2DKD were 0.760 (95% CI 0.6577–0.863, P < 0.001) and 0.862 (95% CI 0.7787–0.937, P < 0.001). Therefore, the inflammatory markers NLR and MCP-1 are risk factors affecting the development of T2DKD, which of clinical value may be used as novel markers of T2DKD.https://doi.org/10.1038/s41598-024-53567-2 |
| spellingShingle | Yaxuan Fang Bin Wang Bo Pang Zijun Zhou Yunze Xing Pai Pang Dingyuan Zheng Gang Zhang Bo Yang Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study Scientific Reports |
| title | Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study |
| title_full | Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study |
| title_fullStr | Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study |
| title_full_unstemmed | Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study |
| title_short | Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study |
| title_sort | exploring the relations of nlr hscrp and mcp 1 with type 2 diabetic kidney disease a cross sectional study |
| url | https://doi.org/10.1038/s41598-024-53567-2 |
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