A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors

A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors

Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional repression and chromatin condensation mechanisms by removing the acetyl moiety from acetylated ε-amino group of histone lysines and other non-histone proteins. In recent years, HDAC8, a class I HDAC, has emerged...

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Bibliographic Details
Main Authors: Anna Fontana, Ilaria Cursaro, Gabriele Carullo, Sandra Gemma, Stefania Butini, Giuseppe Campiani
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
histone deacetylase
HDAC8
HDAC8 inhibitor
fibrosis
cancer
polypharmacology
Online Access:https://www.mdpi.com/1422-0067/23/17/10014

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