Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication
Chronic alcohol myopathy (CAM) is one of frequent manifestationsof the alcoholic disease, but its pathogenesis remains to be elucidated.Main mechanism of the CAM development is suggested tobe abnormalities of protein synthesis in muscle fibers. A complexclinical, morphological and biochemical invest...
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/327/224 |
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| author | Yu. V. Kazantseva G. V. Maslova E. A. Lysenko O. E. Zinovyeva B. S. Shenkman N. N. Yakhno |
| author_facet | Yu. V. Kazantseva G. V. Maslova E. A. Lysenko O. E. Zinovyeva B. S. Shenkman N. N. Yakhno |
| author_sort | Yu. V. Kazantseva |
| collection | DOAJ |
| description | Chronic alcohol myopathy (CAM) is one of frequent manifestationsof the alcoholic disease, but its pathogenesis remains to be elucidated.Main mechanism of the CAM development is suggested tobe abnormalities of protein synthesis in muscle fibers. A complexclinical, morphological and biochemical investigation of 38 patientswith chronic alcohol intoxication was performed. Clinical manifestationsof skeletal muscle damage corresponded to severity of theatrophic process assessed by histological studies of muscle biopsies.Disturbances of main stages of protein synthesis both on intracellularand on systemic regulatory level was revealed. |
| first_indexed | 2024-04-13T18:03:08Z |
| format | Article |
| id | doaj.art-f5b73b0a28924f0fbdb2ee2b371c2c2c |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-04-13T18:03:08Z |
| publishDate | 2017-02-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-f5b73b0a28924f0fbdb2ee2b371c2c2c2022-12-22T02:36:11ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332017-02-0144151910.17816/psaic327225Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxicationYu. V. Kazantseva0G. V. Maslova1E. A. Lysenko2O. E. Zinovyeva3B. S. Shenkman4N. N. Yakhno51st Moscow State Medical University named after I.M. Sechenov1st Moscow State Medical University named after I.M. SechenovInstitute of Medico-Biological Problems, Russian Academy of Sciences (Moscow)1st Moscow State Medical University named after I.M. SechenovInstitute of Medico-Biological Problems, Russian Academy of Sciences (Moscow)1st Moscow State Medical University named after I.M. SechenovChronic alcohol myopathy (CAM) is one of frequent manifestationsof the alcoholic disease, but its pathogenesis remains to be elucidated.Main mechanism of the CAM development is suggested tobe abnormalities of protein synthesis in muscle fibers. A complexclinical, morphological and biochemical investigation of 38 patientswith chronic alcohol intoxication was performed. Clinical manifestationsof skeletal muscle damage corresponded to severity of theatrophic process assessed by histological studies of muscle biopsies.Disturbances of main stages of protein synthesis both on intracellularand on systemic regulatory level was revealed.https://annaly-nevrologii.com/journal/pathID/article/viewFile/327/224chronic alcohol myopathyprotein synthesisinsulin-like growth factor iprotein electrophoresis |
| spellingShingle | Yu. V. Kazantseva G. V. Maslova E. A. Lysenko O. E. Zinovyeva B. S. Shenkman N. N. Yakhno Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication Анналы клинической и экспериментальной неврологии chronic alcohol myopathy protein synthesis insulin-like growth factor i protein electrophoresis |
| title | Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication |
| title_full | Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication |
| title_fullStr | Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication |
| title_full_unstemmed | Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication |
| title_short | Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication |
| title_sort | mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication |
| topic | chronic alcohol myopathy protein synthesis insulin-like growth factor i protein electrophoresis |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/327/224 |
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