Controlling Microparticle Morphology in Melt-Jet Printing of Active Pharmaceutical Ingredients through Surface Phenomena
Achieving homogeneity and reproducibility in the size, shape, and morphology of active pharmaceutical ingredient (API) particles is crucial for their successful manufacturing and performance. Herein, we describe a new method for API particle engineering using melt-jet printing technology as an alter...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/8/2026 |
| _version_ | 1797583521050525696 |
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| author | Shachar Bornstein Almog Uziel Dan Y. Lewitus |
| author_facet | Shachar Bornstein Almog Uziel Dan Y. Lewitus |
| author_sort | Shachar Bornstein |
| collection | DOAJ |
| description | Achieving homogeneity and reproducibility in the size, shape, and morphology of active pharmaceutical ingredient (API) particles is crucial for their successful manufacturing and performance. Herein, we describe a new method for API particle engineering using melt-jet printing technology as an alternative to the current solvent-based particle engineering methods. Paracetamol, a widely used API, was melted and jetted as droplets onto various surfaces to solidify and form microparticles. The influence of different surfaces (glass, aluminum, polytetrafluoroethylene, and polyethylene) on particle shape was investigated, revealing a correlation between substrate properties (heat conduction, surface energy, and roughness) and particle sphericity. Higher thermal conductivity, surface roughness, and decreased surface energy contributed to larger contact angles and increased sphericity, reaching a near-perfect micro-spherical shape on an aluminum substrate. The integrity and polymorphic form of the printed particles were confirmed through differential scanning calorimetry and X-ray diffraction. Additionally, high-performance liquid chromatography analysis revealed minimal degradation products. The applicability of the printing process to other APIs was demonstrated by printing carbamazepine and indomethacin on aluminum surfaces, resulting in spherical microparticles. This study emphasizes the potential of melt-jet printing as a promising approach for the precise engineering of pharmaceutical particles, enabling effective control over their physiochemical properties. |
| first_indexed | 2024-03-10T23:40:06Z |
| format | Article |
| id | doaj.art-f5b785a628eb4239838331e83f5ce599 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T23:40:06Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-f5b785a628eb4239838331e83f5ce5992023-11-19T02:35:34ZengMDPI AGPharmaceutics1999-49232023-07-01158202610.3390/pharmaceutics15082026Controlling Microparticle Morphology in Melt-Jet Printing of Active Pharmaceutical Ingredients through Surface PhenomenaShachar Bornstein0Almog Uziel1Dan Y. Lewitus2Department of Polymer Materials Engineering, Shenkar College of Engineering, Design and Art, Ramat Gan 5252626, IsraelDepartment of Polymer Materials Engineering, Shenkar College of Engineering, Design and Art, Ramat Gan 5252626, IsraelDepartment of Polymer Materials Engineering, Shenkar College of Engineering, Design and Art, Ramat Gan 5252626, IsraelAchieving homogeneity and reproducibility in the size, shape, and morphology of active pharmaceutical ingredient (API) particles is crucial for their successful manufacturing and performance. Herein, we describe a new method for API particle engineering using melt-jet printing technology as an alternative to the current solvent-based particle engineering methods. Paracetamol, a widely used API, was melted and jetted as droplets onto various surfaces to solidify and form microparticles. The influence of different surfaces (glass, aluminum, polytetrafluoroethylene, and polyethylene) on particle shape was investigated, revealing a correlation between substrate properties (heat conduction, surface energy, and roughness) and particle sphericity. Higher thermal conductivity, surface roughness, and decreased surface energy contributed to larger contact angles and increased sphericity, reaching a near-perfect micro-spherical shape on an aluminum substrate. The integrity and polymorphic form of the printed particles were confirmed through differential scanning calorimetry and X-ray diffraction. Additionally, high-performance liquid chromatography analysis revealed minimal degradation products. The applicability of the printing process to other APIs was demonstrated by printing carbamazepine and indomethacin on aluminum surfaces, resulting in spherical microparticles. This study emphasizes the potential of melt-jet printing as a promising approach for the precise engineering of pharmaceutical particles, enabling effective control over their physiochemical properties.https://www.mdpi.com/1999-4923/15/8/2026melt-jet printingactive pharmaceutical ingredients (APIs)particle engineeringmicroparticlessphericitysurface properties |
| spellingShingle | Shachar Bornstein Almog Uziel Dan Y. Lewitus Controlling Microparticle Morphology in Melt-Jet Printing of Active Pharmaceutical Ingredients through Surface Phenomena Pharmaceutics melt-jet printing active pharmaceutical ingredients (APIs) particle engineering microparticles sphericity surface properties |
| title | Controlling Microparticle Morphology in Melt-Jet Printing of Active Pharmaceutical Ingredients through Surface Phenomena |
| title_full | Controlling Microparticle Morphology in Melt-Jet Printing of Active Pharmaceutical Ingredients through Surface Phenomena |
| title_fullStr | Controlling Microparticle Morphology in Melt-Jet Printing of Active Pharmaceutical Ingredients through Surface Phenomena |
| title_full_unstemmed | Controlling Microparticle Morphology in Melt-Jet Printing of Active Pharmaceutical Ingredients through Surface Phenomena |
| title_short | Controlling Microparticle Morphology in Melt-Jet Printing of Active Pharmaceutical Ingredients through Surface Phenomena |
| title_sort | controlling microparticle morphology in melt jet printing of active pharmaceutical ingredients through surface phenomena |
| topic | melt-jet printing active pharmaceutical ingredients (APIs) particle engineering microparticles sphericity surface properties |
| url | https://www.mdpi.com/1999-4923/15/8/2026 |
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