PDTC Alleviates Depressive Symptoms and Colon Tissue Injury via Inhibiting NO Overproduction in CUMS Rats

PDTC Alleviates Depressive Symptoms and Colon Tissue Injury via Inhibiting NO Overproduction in CUMS Rats

BackgroundThe accumulated evidence demonstrates that stress plays an important role in the pathogenesis of depression that is associated with intestinal dysfunctions. However, the mechanisms remain unresolved.MethodsA total of 40 male Wistar rats were obtained and randomly divided into four equal-si...

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Bibliographic Details
Main Authors: Lejin Yang, Hui Chen, Dongdong Wang, Shuping Nie, Jinge Du, Ming Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Neuroscience
Subjects:
chronic and unpredictable mild stress
spinal cord
colon
depression
NF-κB
nitric oxide
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01327/full

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