Concurrent Presence of Hashimoto’s Thyroiditis with Papillary Carcinoma of Thyroid- A Retrospective Study
Introduction: Hashimoto’s thyroiditis is the most common inflammatory disease of thyroid. Papillary carcinoma of thyroid is an epithelial malignancy and is the most frequent thyroid neoplasm. The association between Hashimoto’s thyroiditis and papillary carcinoma of thyroid has been debatable du...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2022-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/15949/50786_CE(Ra1)_F(SS)_PF1(DA_SS)_PFA(SS_DA_KM)_PN(KM).pdf |
| Summary: | Introduction: Hashimoto’s thyroiditis is the most common
inflammatory disease of thyroid. Papillary carcinoma of thyroid
is an epithelial malignancy and is the most frequent thyroid
neoplasm. The association between Hashimoto’s thyroiditis
and papillary carcinoma of thyroid has been debatable due to
conflicting evidence.
Aim: To know the socio-demographic determinants of Hashimoto’s
thyroiditis and to find out the association between Hashimoto’s
thyroiditis and papillary carcinoma of thyroid.
Materials and Methods: In this retrospective study, clinical
and histopathological data of 720 patients who underwent
thyroidectomy between October 2013 to September 2018 were
studied at Father Muller Medical College, Mangalore, Karnataka,
India. Clinical case records, from October 2013 till September
2018, and histopathological reports were collected. The results
were expressed in percentages, proportions and means with
standard deviation. Chi-square test was used to find out the
association of age group, sex and histopathologic findings with
Hashimoto’s thyroiditis. The data was analysed using Statistical
Package for the Social Sciences (SPSS) version 23.0 and
p-value <0.05 was considered as statistically significant.
Results: Mean age of the study participants with and without
Hashimoto’s thyroiditis was 45.94 (±10.60) years and 45.88 (±12.88)
years respectively. Out of 720 study participants, 623 (86.5%)
were females and 97 (13.5%) males. The most common indication
for thyroidectomy was benign thyroid disorders followed by
papillary carcinoma of thyroid. Hashimoto’s thyroiditis was seen
significantly higher in females compared to males (χ2
=12.214,
p<0.001) and odds of females having Hashimoto’s thyroiditis
was 3.76 times that of males. Papillary carcinoma was seen in
157 cases out of 720 cases, and amongst them, 51 (32.5%) had
Hashimoto’s thyroiditis. Papillary carcinoma was found to be
associated with the presence of Hashimoto’s thyroiditis (χ2
=17.5,
p<0.001).
Conclusion: Female sex was the significant socio-demographic
determinant of Hashimoto’s thyroiditis. Papillary carcinoma of
thyroid was found to be associated with Hashimoto’s thyroiditis. |
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| ISSN: | 2249-782X 0973-709X |