Role of differentiated embryo-chondrocyte expressed gene 2 in immunity
Differentiated embryo-chondrocyte expressed gene 2 (DEC2) is a member of the basic helix-loop-helix (bHLH) subfamily of transcription factors. DEC2 is implicated in tumor immunotherapy, immune system function regulation, and autoimmune diseases. DEC2 enhances Th2 cell differentiation by regulating t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335473/full |
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| author | Yujing Li Yujing Li Yinan Ma Yinan Ma Yang Liu Na Tang Na Tang Wenzhu Zhang Wenzhu Zhang Jingru Huo Jingru Huo Di Zhang Di Zhang |
| author_facet | Yujing Li Yujing Li Yinan Ma Yinan Ma Yang Liu Na Tang Na Tang Wenzhu Zhang Wenzhu Zhang Jingru Huo Jingru Huo Di Zhang Di Zhang |
| author_sort | Yujing Li |
| collection | DOAJ |
| description | Differentiated embryo-chondrocyte expressed gene 2 (DEC2) is a member of the basic helix-loop-helix (bHLH) subfamily of transcription factors. DEC2 is implicated in tumor immunotherapy, immune system function regulation, and autoimmune diseases. DEC2 enhances Th2 cell differentiation by regulating the IL-2 and IL-4 signaling pathways and mediates the growth of B-1a cells, thereby promoting the occurrence and development of inflammatory responses. In this study, we review the reported roles of DEC2, including the regulation of immune cell differentiation and cytokine production in various cells in humans, and discuss its potential in treating autoimmune diseases and tumors. |
| first_indexed | 2024-04-25T00:45:48Z |
| format | Article |
| id | doaj.art-f5b8a8fc33344178b0492e14b7599f9d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-25T00:45:48Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f5b8a8fc33344178b0492e14b7599f9d2024-03-12T04:59:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13354731335473Role of differentiated embryo-chondrocyte expressed gene 2 in immunityYujing Li0Yujing Li1Yinan Ma2Yinan Ma3Yang Liu4Na Tang5Na Tang6Wenzhu Zhang7Wenzhu Zhang8Jingru Huo9Jingru Huo10Di Zhang11Di Zhang12Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaDepartment of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, ChinaDifferentiated embryo-chondrocyte expressed gene 2 (DEC2) is a member of the basic helix-loop-helix (bHLH) subfamily of transcription factors. DEC2 is implicated in tumor immunotherapy, immune system function regulation, and autoimmune diseases. DEC2 enhances Th2 cell differentiation by regulating the IL-2 and IL-4 signaling pathways and mediates the growth of B-1a cells, thereby promoting the occurrence and development of inflammatory responses. In this study, we review the reported roles of DEC2, including the regulation of immune cell differentiation and cytokine production in various cells in humans, and discuss its potential in treating autoimmune diseases and tumors.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335473/fullDEC2DEC1Bhlhe41immunityimmune cells |
| spellingShingle | Yujing Li Yujing Li Yinan Ma Yinan Ma Yang Liu Na Tang Na Tang Wenzhu Zhang Wenzhu Zhang Jingru Huo Jingru Huo Di Zhang Di Zhang Role of differentiated embryo-chondrocyte expressed gene 2 in immunity Frontiers in Immunology DEC2 DEC1 Bhlhe41 immunity immune cells |
| title | Role of differentiated embryo-chondrocyte expressed gene 2 in immunity |
| title_full | Role of differentiated embryo-chondrocyte expressed gene 2 in immunity |
| title_fullStr | Role of differentiated embryo-chondrocyte expressed gene 2 in immunity |
| title_full_unstemmed | Role of differentiated embryo-chondrocyte expressed gene 2 in immunity |
| title_short | Role of differentiated embryo-chondrocyte expressed gene 2 in immunity |
| title_sort | role of differentiated embryo chondrocyte expressed gene 2 in immunity |
| topic | DEC2 DEC1 Bhlhe41 immunity immune cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335473/full |
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