Exhaled biomarkers in childhood asthma: old and new approaches
Abstract Background Asthma is a chronic condition usually characterized by underlying inflammation. The study of asthmatic inflammation is of the utmost importance for both diagnostic and monitoring purposes. The gold standard for investigating airway inflammation is bronchoscopy, with bronchoalveol...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | Asthma Research and Practice |
| Online Access: | http://link.springer.com/article/10.1186/s40733-018-0045-6 |
| _version_ | 1818510553048416256 |
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| author | Valentina Ferraro Silvia Carraro Sara Bozzetto Stefania Zanconato Eugenio Baraldi |
| author_facet | Valentina Ferraro Silvia Carraro Sara Bozzetto Stefania Zanconato Eugenio Baraldi |
| author_sort | Valentina Ferraro |
| collection | DOAJ |
| description | Abstract Background Asthma is a chronic condition usually characterized by underlying inflammation. The study of asthmatic inflammation is of the utmost importance for both diagnostic and monitoring purposes. The gold standard for investigating airway inflammation is bronchoscopy, with bronchoalveolar lavage and bronchial biopsy, but the invasiveness of such procedures limits their use in children. For this reason, in the last decades there has been a growing interest for the development of noninvasive methods. Main body In the present review, we describe the most important non-invasive methods for the study of airway inflammation in children, focusing on the measure of the fractional exhaled nitric oxide (feNO), on the measure of the exhaled breath temperature (EBT) and on the analysis of both exhaled breath condensate (EBC) and exhaled air (Volatile Organic Compounds, VOCs), using targeted and untargeted approaches. We summarize what is currently known on the topic of exhaled biomarkers in childhood asthma, with a special emphasis on emerging approaches, underlining the role of exhaled biomarkers in the diagnosis, management and treatment of asthma, and their potential for the development of personalized treatments. Conclusion Among non-invasive methods to study asthma, exhaled breath analysis remains one of the most interesting approaches, feNO and “-omic” sciences seem promising for the purpose of characterizing biomarkers of this disease. |
| first_indexed | 2024-12-10T23:21:31Z |
| format | Article |
| id | doaj.art-f5b922d5a1c946ae956d40ec49d469a6 |
| institution | Directory Open Access Journal |
| issn | 2054-7064 |
| language | English |
| last_indexed | 2024-12-10T23:21:31Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Asthma Research and Practice |
| spelling | doaj.art-f5b922d5a1c946ae956d40ec49d469a62022-12-22T01:29:43ZengBMCAsthma Research and Practice2054-70642018-08-01411710.1186/s40733-018-0045-6Exhaled biomarkers in childhood asthma: old and new approachesValentina Ferraro0Silvia Carraro1Sara Bozzetto2Stefania Zanconato3Eugenio Baraldi4Women’s and Children’s Health Department, University of PadovaWomen’s and Children’s Health Department, University of PadovaWomen’s and Children’s Health Department, University of PadovaWomen’s and Children’s Health Department, University of PadovaWomen’s and Children’s Health Department, University of PadovaAbstract Background Asthma is a chronic condition usually characterized by underlying inflammation. The study of asthmatic inflammation is of the utmost importance for both diagnostic and monitoring purposes. The gold standard for investigating airway inflammation is bronchoscopy, with bronchoalveolar lavage and bronchial biopsy, but the invasiveness of such procedures limits their use in children. For this reason, in the last decades there has been a growing interest for the development of noninvasive methods. Main body In the present review, we describe the most important non-invasive methods for the study of airway inflammation in children, focusing on the measure of the fractional exhaled nitric oxide (feNO), on the measure of the exhaled breath temperature (EBT) and on the analysis of both exhaled breath condensate (EBC) and exhaled air (Volatile Organic Compounds, VOCs), using targeted and untargeted approaches. We summarize what is currently known on the topic of exhaled biomarkers in childhood asthma, with a special emphasis on emerging approaches, underlining the role of exhaled biomarkers in the diagnosis, management and treatment of asthma, and their potential for the development of personalized treatments. Conclusion Among non-invasive methods to study asthma, exhaled breath analysis remains one of the most interesting approaches, feNO and “-omic” sciences seem promising for the purpose of characterizing biomarkers of this disease.http://link.springer.com/article/10.1186/s40733-018-0045-6 |
| spellingShingle | Valentina Ferraro Silvia Carraro Sara Bozzetto Stefania Zanconato Eugenio Baraldi Exhaled biomarkers in childhood asthma: old and new approaches Asthma Research and Practice |
| title | Exhaled biomarkers in childhood asthma: old and new approaches |
| title_full | Exhaled biomarkers in childhood asthma: old and new approaches |
| title_fullStr | Exhaled biomarkers in childhood asthma: old and new approaches |
| title_full_unstemmed | Exhaled biomarkers in childhood asthma: old and new approaches |
| title_short | Exhaled biomarkers in childhood asthma: old and new approaches |
| title_sort | exhaled biomarkers in childhood asthma old and new approaches |
| url | http://link.springer.com/article/10.1186/s40733-018-0045-6 |
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