Diagnostic significance of circulating miRNAs in systemic lupus erythematosus.
<h4>Background</h4>In recent years, many studies focused on the association between the microRNAs (miRNAs) and the risk of systemic lupus erythematosus (SLE), especially miRNA-21 (miR-21). We aimed to investigate the role of circulating miRNAs, especially the miR-21, as a biomarker in de...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0217523 |
| _version_ | 1819142359631265792 |
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| author | Xiaolan Zheng Yi Zhang Peng Yue Lei Liu Chuan Wang Kaiyu Zhou Yimin Hua Gang Wu Yifei Li |
| author_facet | Xiaolan Zheng Yi Zhang Peng Yue Lei Liu Chuan Wang Kaiyu Zhou Yimin Hua Gang Wu Yifei Li |
| author_sort | Xiaolan Zheng |
| collection | DOAJ |
| description | <h4>Background</h4>In recent years, many studies focused on the association between the microRNAs (miRNAs) and the risk of systemic lupus erythematosus (SLE), especially miRNA-21 (miR-21). We aimed to investigate the role of circulating miRNAs, especially the miR-21, as a biomarker in detecting SLE.<h4>Methods</h4>We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and China National Knowledge Infrastructure through Mar 3th, 2019. We performed this meta-analysis in a fixed/random-effect model using Meta-disc 1.4 and STATA 15.1.<h4>Results</h4>A total of 17 relevant studies were eligible to analyze pooled accuracy. The overall performance of total mixed miRNAs (TmiRs) detection was: pooled sensitivity, 0.71 (95% confidence interval [CI], 0.69 to 0.72); pooled specificity, 0.81 (95%CI, 0.79 to 0.83); and area under the summary receiver operating characteristic curves value (SROC), 0.8797. The miR-21 detection was: pooled sensitivity, 0.68 (95%CI, 0.62 to 0.74); pooled specificity, 0.77 (95%CI, 0.69 to 0.84); and SROC, 0.8281. The meta-regression analysis showed that the type of samples was the sources of heterogeneity. The subgroup analysis suggested that detection in plasma group had the largest AUC of SROC in all the subgroups: pooled sensitivity, 0.8 (95%CI, 0.78 to 0.82); pooled specificity, 0.83 (95%CI, 0.8 to 0.86); and SROC, 0.9068.<h4>Conclusions</h4>Our meta-analysis demonstrated that circulating miRNAs might be potential novel biomarkers for detecting SLE, especially miR-21. Moreover, plasma is recommended as the clinical specimen for diagnostic detection. |
| first_indexed | 2024-12-22T12:09:06Z |
| format | Article |
| id | doaj.art-f5b97a169e554aea9b1004718143e100 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T12:09:06Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f5b97a169e554aea9b1004718143e1002022-12-21T18:26:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01146e021752310.1371/journal.pone.0217523Diagnostic significance of circulating miRNAs in systemic lupus erythematosus.Xiaolan ZhengYi ZhangPeng YueLei LiuChuan WangKaiyu ZhouYimin HuaGang WuYifei Li<h4>Background</h4>In recent years, many studies focused on the association between the microRNAs (miRNAs) and the risk of systemic lupus erythematosus (SLE), especially miRNA-21 (miR-21). We aimed to investigate the role of circulating miRNAs, especially the miR-21, as a biomarker in detecting SLE.<h4>Methods</h4>We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and China National Knowledge Infrastructure through Mar 3th, 2019. We performed this meta-analysis in a fixed/random-effect model using Meta-disc 1.4 and STATA 15.1.<h4>Results</h4>A total of 17 relevant studies were eligible to analyze pooled accuracy. The overall performance of total mixed miRNAs (TmiRs) detection was: pooled sensitivity, 0.71 (95% confidence interval [CI], 0.69 to 0.72); pooled specificity, 0.81 (95%CI, 0.79 to 0.83); and area under the summary receiver operating characteristic curves value (SROC), 0.8797. The miR-21 detection was: pooled sensitivity, 0.68 (95%CI, 0.62 to 0.74); pooled specificity, 0.77 (95%CI, 0.69 to 0.84); and SROC, 0.8281. The meta-regression analysis showed that the type of samples was the sources of heterogeneity. The subgroup analysis suggested that detection in plasma group had the largest AUC of SROC in all the subgroups: pooled sensitivity, 0.8 (95%CI, 0.78 to 0.82); pooled specificity, 0.83 (95%CI, 0.8 to 0.86); and SROC, 0.9068.<h4>Conclusions</h4>Our meta-analysis demonstrated that circulating miRNAs might be potential novel biomarkers for detecting SLE, especially miR-21. Moreover, plasma is recommended as the clinical specimen for diagnostic detection.https://doi.org/10.1371/journal.pone.0217523 |
| spellingShingle | Xiaolan Zheng Yi Zhang Peng Yue Lei Liu Chuan Wang Kaiyu Zhou Yimin Hua Gang Wu Yifei Li Diagnostic significance of circulating miRNAs in systemic lupus erythematosus. PLoS ONE |
| title | Diagnostic significance of circulating miRNAs in systemic lupus erythematosus. |
| title_full | Diagnostic significance of circulating miRNAs in systemic lupus erythematosus. |
| title_fullStr | Diagnostic significance of circulating miRNAs in systemic lupus erythematosus. |
| title_full_unstemmed | Diagnostic significance of circulating miRNAs in systemic lupus erythematosus. |
| title_short | Diagnostic significance of circulating miRNAs in systemic lupus erythematosus. |
| title_sort | diagnostic significance of circulating mirnas in systemic lupus erythematosus |
| url | https://doi.org/10.1371/journal.pone.0217523 |
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