A case of diffuse midline glioma with histone H3 K27M mutation mimicking long segmental myelitis
Diffuse midline glioma with H3 K27M mutation is a new tumor entity from 2016 which is highly aggressive and classified as a WHO Grade IV tumor regardless of histopathologic features. We report a case of a 40-year-old male with diffuse midline glioma with pathology confirmation of histone H3 K27M mut...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Interdisciplinary Neurosurgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214751920305661 |
| _version_ | 1819060524238766080 |
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| author | Hsin-Pin Lin Cuiping Zhao Vyas Viswanathan Anthony T. Yachnis James Wymer |
| author_facet | Hsin-Pin Lin Cuiping Zhao Vyas Viswanathan Anthony T. Yachnis James Wymer |
| author_sort | Hsin-Pin Lin |
| collection | DOAJ |
| description | Diffuse midline glioma with H3 K27M mutation is a new tumor entity from 2016 which is highly aggressive and classified as a WHO Grade IV tumor regardless of histopathologic features. We report a case of a 40-year-old male with diffuse midline glioma with pathology confirmation of histone H3 K27M mutation presenting predominately with subacute lower motor neuron syndrome mimicking long segmental myelitis. Our case will remind physicians that diffuse midline gliomas with H3 K27M mutation should be considered for differential diagnosis when there is long segmental spinal cord lesion. Careful evaluation should be done when there is atypical clinical manifestation. |
| first_indexed | 2024-12-21T14:28:21Z |
| format | Article |
| id | doaj.art-f5baa663c9ad40ffad5988a93541e287 |
| institution | Directory Open Access Journal |
| issn | 2214-7519 |
| language | English |
| last_indexed | 2024-12-21T14:28:21Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Interdisciplinary Neurosurgery |
| spelling | doaj.art-f5baa663c9ad40ffad5988a93541e2872022-12-21T19:00:35ZengElsevierInterdisciplinary Neurosurgery2214-75192021-03-0123101005A case of diffuse midline glioma with histone H3 K27M mutation mimicking long segmental myelitisHsin-Pin Lin0Cuiping Zhao1Vyas Viswanathan2Anthony T. Yachnis3James Wymer4Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USADepartment of Neurology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, ChinaDepartment of Neurology, College of Medicine, University of Florida, Gainesville, FL, USADepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USADepartment of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA; Corresponding author at: Department of Neurology, University of Florida, HSC Box 100236, Gainesville, FL 32610, USA.Diffuse midline glioma with H3 K27M mutation is a new tumor entity from 2016 which is highly aggressive and classified as a WHO Grade IV tumor regardless of histopathologic features. We report a case of a 40-year-old male with diffuse midline glioma with pathology confirmation of histone H3 K27M mutation presenting predominately with subacute lower motor neuron syndrome mimicking long segmental myelitis. Our case will remind physicians that diffuse midline gliomas with H3 K27M mutation should be considered for differential diagnosis when there is long segmental spinal cord lesion. Careful evaluation should be done when there is atypical clinical manifestation.http://www.sciencedirect.com/science/article/pii/S2214751920305661Diffuse midline gliomaH3 K27M mutationMyelitisLower motor neuron syndromeGliomaAstrocytoma |
| spellingShingle | Hsin-Pin Lin Cuiping Zhao Vyas Viswanathan Anthony T. Yachnis James Wymer A case of diffuse midline glioma with histone H3 K27M mutation mimicking long segmental myelitis Interdisciplinary Neurosurgery Diffuse midline glioma H3 K27M mutation Myelitis Lower motor neuron syndrome Glioma Astrocytoma |
| title | A case of diffuse midline glioma with histone H3 K27M mutation mimicking long segmental myelitis |
| title_full | A case of diffuse midline glioma with histone H3 K27M mutation mimicking long segmental myelitis |
| title_fullStr | A case of diffuse midline glioma with histone H3 K27M mutation mimicking long segmental myelitis |
| title_full_unstemmed | A case of diffuse midline glioma with histone H3 K27M mutation mimicking long segmental myelitis |
| title_short | A case of diffuse midline glioma with histone H3 K27M mutation mimicking long segmental myelitis |
| title_sort | case of diffuse midline glioma with histone h3 k27m mutation mimicking long segmental myelitis |
| topic | Diffuse midline glioma H3 K27M mutation Myelitis Lower motor neuron syndrome Glioma Astrocytoma |
| url | http://www.sciencedirect.com/science/article/pii/S2214751920305661 |
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