Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study
ObjectivesThis study aims to explore the relationship between bone-turnover biomarkers and the recovery of SSNHL to provide clues for further improvements in etiological research and predictors.MethodsThe medical history, hearing thresholds, biomarkers of bone-turnover, and related hormones of 117 S...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.980150/full |
| _version_ | 1817998512531439616 |
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| author | Xiaoyan Chen Xiaoyan Chen Zhong Zheng Zhong Zheng Lili Xiao Lili Xiao Chengqi Liu Chengqi Liu Ying Shen Ying Shen Ning Ma Ning Ma Hongjun Dong Shankai Yin Shankai Yin Yanmei Feng Yanmei Feng |
| author_facet | Xiaoyan Chen Xiaoyan Chen Zhong Zheng Zhong Zheng Lili Xiao Lili Xiao Chengqi Liu Chengqi Liu Ying Shen Ying Shen Ning Ma Ning Ma Hongjun Dong Shankai Yin Shankai Yin Yanmei Feng Yanmei Feng |
| author_sort | Xiaoyan Chen |
| collection | DOAJ |
| description | ObjectivesThis study aims to explore the relationship between bone-turnover biomarkers and the recovery of SSNHL to provide clues for further improvements in etiological research and predictors.MethodsThe medical history, hearing thresholds, biomarkers of bone-turnover, and related hormones of 117 SSNHL patients were collected prospectively between August 2018 and December 2021. Linear correlation and logistic regression models were applied to examine the association between bone-turnover biomarkers and the prognosis of SSNHL.ResultsAge, the incidence of vertigo, pure tone average of the impaired frequencies (PTAimpairedfre), and the levels of bone turnover [including alkaline phosphatase (ALP), β-carboxy terminal crosslinked telopeptide of type 1 collagen (β-CTX), and N-terminal-midfragment of osteocalcin (N-MID)] were higher in the nonresponders than responders (P < 0.05). Logistic regression showed that the age (OR = 1.035, P = 0.027), time to treatment (OR = 1.157, P = 0.038), PTAimpairedfre (OR = 1.031, P = 0.008), and β-CTX (OR = 1.004, P = 0.001) were independent risk factors for the prognosis of SSNHL. In the women SSNHL subgroup, age, postmenopause percentage, PTAimpairedfre, the activity of ALP, levels of β-CTX, and N-MID were significantly higher in the nonresponders than the responders (P < 0.05). Compared to the men SSNHL subgroup, β-CTX has a higher correlation coefficient and predictive efficiency in the women SSNHL subgroup, and logistic regression showed that β-CTX (OR = 1.004, P = 0.004) was an independent risk factor for the women SSNHL.ConclusionsBone-turnover biomarkers are risk factors for poor prognosis in SSNHL, especially β-CTX. The differences were significant in women SSNHL, which may be related to the rapid regression of estrogen after menopause that leads to the occurrence of osteoporosis with a high conversion rate. |
| first_indexed | 2024-04-14T02:54:10Z |
| format | Article |
| id | doaj.art-f5bbb2c66b7742a7b37f42352b3b498d |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-14T02:54:10Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-f5bbb2c66b7742a7b37f42352b3b498d2022-12-22T02:16:10ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-08-011310.3389/fneur.2022.980150980150Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort studyXiaoyan Chen0Xiaoyan Chen1Zhong Zheng2Zhong Zheng3Lili Xiao4Lili Xiao5Chengqi Liu6Chengqi Liu7Ying Shen8Ying Shen9Ning Ma10Ning Ma11Hongjun Dong12Shankai Yin13Shankai Yin14Yanmei Feng15Yanmei Feng16Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Otorhinolaryngology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaObjectivesThis study aims to explore the relationship between bone-turnover biomarkers and the recovery of SSNHL to provide clues for further improvements in etiological research and predictors.MethodsThe medical history, hearing thresholds, biomarkers of bone-turnover, and related hormones of 117 SSNHL patients were collected prospectively between August 2018 and December 2021. Linear correlation and logistic regression models were applied to examine the association between bone-turnover biomarkers and the prognosis of SSNHL.ResultsAge, the incidence of vertigo, pure tone average of the impaired frequencies (PTAimpairedfre), and the levels of bone turnover [including alkaline phosphatase (ALP), β-carboxy terminal crosslinked telopeptide of type 1 collagen (β-CTX), and N-terminal-midfragment of osteocalcin (N-MID)] were higher in the nonresponders than responders (P < 0.05). Logistic regression showed that the age (OR = 1.035, P = 0.027), time to treatment (OR = 1.157, P = 0.038), PTAimpairedfre (OR = 1.031, P = 0.008), and β-CTX (OR = 1.004, P = 0.001) were independent risk factors for the prognosis of SSNHL. In the women SSNHL subgroup, age, postmenopause percentage, PTAimpairedfre, the activity of ALP, levels of β-CTX, and N-MID were significantly higher in the nonresponders than the responders (P < 0.05). Compared to the men SSNHL subgroup, β-CTX has a higher correlation coefficient and predictive efficiency in the women SSNHL subgroup, and logistic regression showed that β-CTX (OR = 1.004, P = 0.004) was an independent risk factor for the women SSNHL.ConclusionsBone-turnover biomarkers are risk factors for poor prognosis in SSNHL, especially β-CTX. The differences were significant in women SSNHL, which may be related to the rapid regression of estrogen after menopause that leads to the occurrence of osteoporosis with a high conversion rate.https://www.frontiersin.org/articles/10.3389/fneur.2022.980150/fullsudden sensorineural hearing lossbone-turnover biomarkersosteoporosisprognosisβ-carboxy terminal crosslinked telopeptide of type 1 collagenN-terminal-midfragment of osteocalcin |
| spellingShingle | Xiaoyan Chen Xiaoyan Chen Zhong Zheng Zhong Zheng Lili Xiao Lili Xiao Chengqi Liu Chengqi Liu Ying Shen Ying Shen Ning Ma Ning Ma Hongjun Dong Shankai Yin Shankai Yin Yanmei Feng Yanmei Feng Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study Frontiers in Neurology sudden sensorineural hearing loss bone-turnover biomarkers osteoporosis prognosis β-carboxy terminal crosslinked telopeptide of type 1 collagen N-terminal-midfragment of osteocalcin |
| title | Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study |
| title_full | Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study |
| title_fullStr | Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study |
| title_full_unstemmed | Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study |
| title_short | Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study |
| title_sort | bone turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss a prospective cohort study |
| topic | sudden sensorineural hearing loss bone-turnover biomarkers osteoporosis prognosis β-carboxy terminal crosslinked telopeptide of type 1 collagen N-terminal-midfragment of osteocalcin |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.980150/full |
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