SARS-CoV-2 Infection in Hereditary Hemorrhagic Telangiectasia Patients Suggests Less Clinical Impact Than in the General Population
At the moment of writing this communication, the health crisis derived from the COVID-19 pandemic has affected more than 120 million cases, with 40 million corresponding to Europe. In total, the number of deaths is almost 3 million, but continuously rising. Although COVID-19 is primarily a respirato...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/9/1884 |
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| author | Sol Marcos Virginia Albiñana Lucia Recio-Poveda Belisa Tarazona María Patrocinio Verde-González Luisa Ojeda-Fernández Luisa-María Botella |
| author_facet | Sol Marcos Virginia Albiñana Lucia Recio-Poveda Belisa Tarazona María Patrocinio Verde-González Luisa Ojeda-Fernández Luisa-María Botella |
| author_sort | Sol Marcos |
| collection | DOAJ |
| description | At the moment of writing this communication, the health crisis derived from the COVID-19 pandemic has affected more than 120 million cases, with 40 million corresponding to Europe. In total, the number of deaths is almost 3 million, but continuously rising. Although COVID-19 is primarily a respiratory disease, SARS-CoV-2 infects also endothelial cells in the pulmonary capillaries. This affects the integrity of the endothelium and increases vascular permeability. In addition, there are serious indirect consequences, like disruption of endothelial cells’ junctions leading to micro-bleeds and uncontrolled blood clotting. The impact of COVID-19 in people with rare chronic cardiovascular diseases is unknown so far, and interesting to assess, because the virus may cause additional complications in these patients. The aim of the present work was to study the COVID-19 infection among the patients with Hereditary Hemorrhagic Telangiectasia (HHT). A retrospective study was carried out in a 138 HHT patients’ sample attending an Ear Nose and Throat (ENT) reference consult. The evaluation of the COVID-19 infection in them reveals milder symptoms; among the 25 HHT patients who were infected, only 3 cases were hospitalized, and none of them required ICU or ventilation assistance. The results are discussed in the light of macrophage immune response. |
| first_indexed | 2024-03-10T11:56:31Z |
| format | Article |
| id | doaj.art-f5bcdfd937284bbfa4af4ec0f20fa4db |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T11:56:31Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f5bcdfd937284bbfa4af4ec0f20fa4db2023-11-21T17:20:40ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01109188410.3390/jcm10091884SARS-CoV-2 Infection in Hereditary Hemorrhagic Telangiectasia Patients Suggests Less Clinical Impact Than in the General PopulationSol Marcos0Virginia Albiñana1Lucia Recio-Poveda2Belisa Tarazona3María Patrocinio Verde-González4Luisa Ojeda-Fernández5Luisa-María Botella6Otorrinolaringology Department, Hospital Universitario Fundación Alcorcón, 28922 Madrid, SpainMolecular Biomedicine Department, Centro de Investigaciones Biológicas Margarita Salas, CSIC, 28040 Madrid, SpainMolecular Biomedicine Department, Centro de Investigaciones Biológicas Margarita Salas, CSIC, 28040 Madrid, SpainPreventive Medicine and Public Health Department, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, SpainHealth Centre Barrio del Pilar, SERMAS, 28029 Madrid, SpainMolecular Biomedicine Department, Centro de Investigaciones Biológicas Margarita Salas, CSIC, 28040 Madrid, SpainMolecular Biomedicine Department, Centro de Investigaciones Biológicas Margarita Salas, CSIC, 28040 Madrid, SpainAt the moment of writing this communication, the health crisis derived from the COVID-19 pandemic has affected more than 120 million cases, with 40 million corresponding to Europe. In total, the number of deaths is almost 3 million, but continuously rising. Although COVID-19 is primarily a respiratory disease, SARS-CoV-2 infects also endothelial cells in the pulmonary capillaries. This affects the integrity of the endothelium and increases vascular permeability. In addition, there are serious indirect consequences, like disruption of endothelial cells’ junctions leading to micro-bleeds and uncontrolled blood clotting. The impact of COVID-19 in people with rare chronic cardiovascular diseases is unknown so far, and interesting to assess, because the virus may cause additional complications in these patients. The aim of the present work was to study the COVID-19 infection among the patients with Hereditary Hemorrhagic Telangiectasia (HHT). A retrospective study was carried out in a 138 HHT patients’ sample attending an Ear Nose and Throat (ENT) reference consult. The evaluation of the COVID-19 infection in them reveals milder symptoms; among the 25 HHT patients who were infected, only 3 cases were hospitalized, and none of them required ICU or ventilation assistance. The results are discussed in the light of macrophage immune response.https://www.mdpi.com/2077-0383/10/9/1884SARS-CoV-2COVID-19hereditary hemorrhagic telangiectasia (HHT)pandemicACE2 receptorinflammation |
| spellingShingle | Sol Marcos Virginia Albiñana Lucia Recio-Poveda Belisa Tarazona María Patrocinio Verde-González Luisa Ojeda-Fernández Luisa-María Botella SARS-CoV-2 Infection in Hereditary Hemorrhagic Telangiectasia Patients Suggests Less Clinical Impact Than in the General Population Journal of Clinical Medicine SARS-CoV-2 COVID-19 hereditary hemorrhagic telangiectasia (HHT) pandemic ACE2 receptor inflammation |
| title | SARS-CoV-2 Infection in Hereditary Hemorrhagic Telangiectasia Patients Suggests Less Clinical Impact Than in the General Population |
| title_full | SARS-CoV-2 Infection in Hereditary Hemorrhagic Telangiectasia Patients Suggests Less Clinical Impact Than in the General Population |
| title_fullStr | SARS-CoV-2 Infection in Hereditary Hemorrhagic Telangiectasia Patients Suggests Less Clinical Impact Than in the General Population |
| title_full_unstemmed | SARS-CoV-2 Infection in Hereditary Hemorrhagic Telangiectasia Patients Suggests Less Clinical Impact Than in the General Population |
| title_short | SARS-CoV-2 Infection in Hereditary Hemorrhagic Telangiectasia Patients Suggests Less Clinical Impact Than in the General Population |
| title_sort | sars cov 2 infection in hereditary hemorrhagic telangiectasia patients suggests less clinical impact than in the general population |
| topic | SARS-CoV-2 COVID-19 hereditary hemorrhagic telangiectasia (HHT) pandemic ACE2 receptor inflammation |
| url | https://www.mdpi.com/2077-0383/10/9/1884 |
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