Potential treatments of COVID-19: Drug repurposing and therapeutic interventions
The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is caused when Spike-protein (S-protein) present on the surface of SARS-CoV-2 interacts with human cell surface receptor, Angiotensin-converting enzyme 2 (ACE2). This bind...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861323000099 |
| _version_ | 1797847736833277952 |
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| author | Pawan Kumar Raghav Zoya Mann Simran Kaur Ahluwalia Raja Rajalingam |
| author_facet | Pawan Kumar Raghav Zoya Mann Simran Kaur Ahluwalia Raja Rajalingam |
| author_sort | Pawan Kumar Raghav |
| collection | DOAJ |
| description | The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is caused when Spike-protein (S-protein) present on the surface of SARS-CoV-2 interacts with human cell surface receptor, Angiotensin-converting enzyme 2 (ACE2). This binding facilitates SARS-CoV-2 genome entry into the human cells, which in turn causes infection. Since the beginning of the pandemic, many different therapies have been developed to combat COVID-19, including treatment and prevention. This review is focused on the currently adapted and certain other potential therapies for COVID-19 treatment, which include drug repurposing, vaccines and drug-free therapies. The efficacy of various treatment options is constantly being tested through clinical trials and in vivo studies before they are made medically available to the public. |
| first_indexed | 2024-04-09T18:17:03Z |
| format | Article |
| id | doaj.art-f5c27643ec354a4ca721939992db51a7 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-09T18:17:03Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-f5c27643ec354a4ca721939992db51a72023-04-13T04:26:26ZengElsevierJournal of Pharmacological Sciences1347-86132023-05-011521121Potential treatments of COVID-19: Drug repurposing and therapeutic interventionsPawan Kumar Raghav0Zoya Mann1Simran Kaur Ahluwalia2Raja Rajalingam3Immunogenetics and Transplantation Laboratory, Department of Surgery, University of California San Francisco, San Francisco, CA, USA; Corresponding author.BioExIn, Delhi, IndiaAmity Institute of Biotechnology, Amity University, Sector-125, Noida, Uttar Pradesh, IndiaImmunogenetics and Transplantation Laboratory, Department of Surgery, University of California San Francisco, San Francisco, CA, USAThe coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is caused when Spike-protein (S-protein) present on the surface of SARS-CoV-2 interacts with human cell surface receptor, Angiotensin-converting enzyme 2 (ACE2). This binding facilitates SARS-CoV-2 genome entry into the human cells, which in turn causes infection. Since the beginning of the pandemic, many different therapies have been developed to combat COVID-19, including treatment and prevention. This review is focused on the currently adapted and certain other potential therapies for COVID-19 treatment, which include drug repurposing, vaccines and drug-free therapies. The efficacy of various treatment options is constantly being tested through clinical trials and in vivo studies before they are made medically available to the public.http://www.sciencedirect.com/science/article/pii/S1347861323000099COVID-19SARS-CoV-2VaccinesClinical trialsDrug repurposing |
| spellingShingle | Pawan Kumar Raghav Zoya Mann Simran Kaur Ahluwalia Raja Rajalingam Potential treatments of COVID-19: Drug repurposing and therapeutic interventions Journal of Pharmacological Sciences COVID-19 SARS-CoV-2 Vaccines Clinical trials Drug repurposing |
| title | Potential treatments of COVID-19: Drug repurposing and therapeutic interventions |
| title_full | Potential treatments of COVID-19: Drug repurposing and therapeutic interventions |
| title_fullStr | Potential treatments of COVID-19: Drug repurposing and therapeutic interventions |
| title_full_unstemmed | Potential treatments of COVID-19: Drug repurposing and therapeutic interventions |
| title_short | Potential treatments of COVID-19: Drug repurposing and therapeutic interventions |
| title_sort | potential treatments of covid 19 drug repurposing and therapeutic interventions |
| topic | COVID-19 SARS-CoV-2 Vaccines Clinical trials Drug repurposing |
| url | http://www.sciencedirect.com/science/article/pii/S1347861323000099 |
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