Time-resolved single-cell RNAseq profiling identifies a novel Fabp5+ subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury

Time-resolved single-cell RNAseq profiling identifies a novel Fabp5+ subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury

Traumatic spinal cord injuries (SCI) are a group of highly debilitating pathologies affecting thousands annually, and adversely affecting quality of life. Currently, no fully restorative therapies exist, and SCI still results in significant personal, societal and financial burdens. Inflammation play...

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Bibliographic Details
Main Authors: Regan Hamel, Luca Peruzzotti-Jametti, Katherine Ridley, Veronica Testa, Bryan Yu, David Rowitch, John C. Marioni, Stefano Pluchino
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Heliyon
Subjects:
Single cell RNA sequencing
Neuroinflammation
Fatty acid binding protein 5
Spinal cord injury
Fate-mapping myeloid cells
Myeloid cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023055470

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