BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome

BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome

The Glucocorticoid Receptor (GR) alters transcriptional activity in response to hormones by interacting with chromatin at GR binding sites (GBSs) throughout the genome. Our work in human breast cancer cells identifies three classes of GBSs with distinct epigenetic characteristics and reveals that BR...

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Bibliographic Details
Main Authors: Jackson A Hoffman, Kevin W Trotter, James M Ward, Trevor K Archer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
chromatin
transcription factors
brg1
glucocorticoid receptor
pioneer factors
histone modifications
Online Access:https://elifesciences.org/articles/35073

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