Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy
Normal aging is associated with brain atrophy and cognitive decline. Working memory, involved in cognitive functioning and daily living, is particularly affected. Music training gained momentum in research on brain plasticity and possible transfer effects of interventions on working memory, especial...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Neuroimage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956023000119 |
| _version_ | 1827979963858419712 |
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| author | Damien Marie Cécile A.H. Müller Eckart Altenmüller Dimitri Van De Ville Kristin Jünemann Daniel S. Scholz Tillmann H.C. Krüger Florian Worschech Matthias Kliegel Christopher Sinke Clara E. James |
| author_facet | Damien Marie Cécile A.H. Müller Eckart Altenmüller Dimitri Van De Ville Kristin Jünemann Daniel S. Scholz Tillmann H.C. Krüger Florian Worschech Matthias Kliegel Christopher Sinke Clara E. James |
| author_sort | Damien Marie |
| collection | DOAJ |
| description | Normal aging is associated with brain atrophy and cognitive decline. Working memory, involved in cognitive functioning and daily living, is particularly affected. Music training gained momentum in research on brain plasticity and possible transfer effects of interventions on working memory, especially in the context of healthy aging. This longitudinal voxel-based morphometry study evaluated effects of 6-month music interventions on grey matter volume plasticity and auditory working memory performance in 132 healthy older adults. This study is part of a randomized controlled trial comparing two interventions: piano practice (experimental group) and musical culture (musical listening awareness, active control). We report significant grey matter volume increase at whole-brain level in the caudate nucleus, Rolandic operculum and inferior cerebellum when merging both groups, but no group differences. Cerebellar grey matter increase, training intensity metrics and sleep were positively associated with tonal working memory improvement. Digit Span Backward verbal working memory performance also increased. Using region of interest analyses, we showed a group difference in the right primary auditory cortex grey matter volume, decreasing in the musical group while staying stable in the piano group. In contrast, a significant 6-month whole-brain atrophy pattern consistent with longer-term investigations of the aging brain was revealed. We argue that education for seniors should become a major policy priority in the framework of healthy aging, to promote brain plasticity and cognitive reserve, through stimulating group interventions such as music-making and active listening. |
| first_indexed | 2024-04-09T21:45:05Z |
| format | Article |
| id | doaj.art-f5c83748c3be48d8a4bad7b248dca05a |
| institution | Directory Open Access Journal |
| issn | 2666-9560 |
| language | English |
| last_indexed | 2024-04-09T21:45:05Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroimage: Reports |
| spelling | doaj.art-f5c83748c3be48d8a4bad7b248dca05a2023-03-25T05:15:43ZengElsevierNeuroimage: Reports2666-95602023-06-0132100166Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophyDamien Marie0Cécile A.H. Müller1Eckart Altenmüller2Dimitri Van De Ville3Kristin Jünemann4Daniel S. Scholz5Tillmann H.C. Krüger6Florian Worschech7Matthias Kliegel8Christopher Sinke9Clara E. James10Geneva Musical Minds Lab, Geneva School of Health Sciences, University of Applied Sciences and Arts Western Switzerland (HES-SO), Geneva, Switzerland; Faculty of Psychology and Educational Sciences, University of Geneva (UNIGE), Geneva, Switzerland; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland; CIBM Center for Biomedical Imaging, MRI HUG-UNIGE, Geneva, Switzerland; Corresponding author. Geneva Musical Minds Lab, Geneva School of Health Sciences, University of Applied Sciences and Arts Western Switzerland (HES-SO), Geneva, Switzerland.Geneva Musical Minds Lab, Geneva School of Health Sciences, University of Applied Sciences and Arts Western Switzerland (HES-SO), Geneva, Switzerland; Faculty of Psychology and Educational Sciences, University of Geneva (UNIGE), Geneva, SwitzerlandInstitute of Music Physiology and Musicians' Medicine, Hanover University of Music, Drama and Media, Hanover, Germany; Center for Systems Neuroscience, Hanover, GermanyNeuro-X Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland; Faculty of Medicine, University of Geneva, Campus Biotech, Geneva, Switzerland; CIBM Center for Biomedical Imaging, MRI EPFL & SP UNIGE-EPFL, Geneva, SwitzerlandCenter for Systems Neuroscience, Hanover, Germany; Division of Clinical Psychology & Sexual Medicine, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hanover Medical School, Hanover, GermanyInstitute of Music Physiology and Musicians' Medicine, Hanover University of Music, Drama and Media, Hanover, Germany; Center for Systems Neuroscience, Hanover, GermanyCenter for Systems Neuroscience, Hanover, Germany; Division of Clinical Psychology & Sexual Medicine, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hanover Medical School, Hanover, GermanyInstitute of Music Physiology and Musicians' Medicine, Hanover University of Music, Drama and Media, Hanover, Germany; Center for Systems Neuroscience, Hanover, GermanyFaculty of Psychology and Educational Sciences, University of Geneva (UNIGE), Geneva, Switzerland; Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Geneva, SwitzerlandCenter for Systems Neuroscience, Hanover, Germany; Division of Clinical Psychology & Sexual Medicine, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hanover Medical School, Hanover, GermanyGeneva Musical Minds Lab, Geneva School of Health Sciences, University of Applied Sciences and Arts Western Switzerland (HES-SO), Geneva, Switzerland; Faculty of Psychology and Educational Sciences, University of Geneva (UNIGE), Geneva, Switzerland; Corresponding author. Faculty of Psychology and Educational Sciences, University of Geneva (UNIGE), Geneva, Switzerland.Normal aging is associated with brain atrophy and cognitive decline. Working memory, involved in cognitive functioning and daily living, is particularly affected. Music training gained momentum in research on brain plasticity and possible transfer effects of interventions on working memory, especially in the context of healthy aging. This longitudinal voxel-based morphometry study evaluated effects of 6-month music interventions on grey matter volume plasticity and auditory working memory performance in 132 healthy older adults. This study is part of a randomized controlled trial comparing two interventions: piano practice (experimental group) and musical culture (musical listening awareness, active control). We report significant grey matter volume increase at whole-brain level in the caudate nucleus, Rolandic operculum and inferior cerebellum when merging both groups, but no group differences. Cerebellar grey matter increase, training intensity metrics and sleep were positively associated with tonal working memory improvement. Digit Span Backward verbal working memory performance also increased. Using region of interest analyses, we showed a group difference in the right primary auditory cortex grey matter volume, decreasing in the musical group while staying stable in the piano group. In contrast, a significant 6-month whole-brain atrophy pattern consistent with longer-term investigations of the aging brain was revealed. We argue that education for seniors should become a major policy priority in the framework of healthy aging, to promote brain plasticity and cognitive reserve, through stimulating group interventions such as music-making and active listening.http://www.sciencedirect.com/science/article/pii/S2666956023000119Brain plasticityWorking memoryAtrophyGrey matterMusicAging |
| spellingShingle | Damien Marie Cécile A.H. Müller Eckart Altenmüller Dimitri Van De Ville Kristin Jünemann Daniel S. Scholz Tillmann H.C. Krüger Florian Worschech Matthias Kliegel Christopher Sinke Clara E. James Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy Neuroimage: Reports Brain plasticity Working memory Atrophy Grey matter Music Aging |
| title | Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy |
| title_full | Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy |
| title_fullStr | Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy |
| title_full_unstemmed | Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy |
| title_short | Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy |
| title_sort | music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory despite general brain atrophy |
| topic | Brain plasticity Working memory Atrophy Grey matter Music Aging |
| url | http://www.sciencedirect.com/science/article/pii/S2666956023000119 |
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