3D collagen matrices modulate the transcriptional trajectory of bone marrow hematopoietic progenitors into macrophage lineage commitment

3D collagen matrices modulate the transcriptional trajectory of bone marrow hematopoietic progenitors into macrophage lineage commitment

Physical signals provided by the extracellular matrix (ECM) are key microenvironmental parameters for the fate decision of hematopoietic stem and progenitor cells (HSPC) in bone marrow. Insights into cell-ECM interactions are critical for advancing HSC-based tissue engineering. Herein, we employed c...

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Bibliographic Details
Main Authors: Pan Zhang, Linmu Xu, Jingsong Gao, Guangkui Xu, Yanping Song, Guang Li, Jingjing Ren, Yunjie Zhang, Cheng Yang, Yu Zhang, Ruiheng Xie, Nu Zhang, Hui Yang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-04-01
Series:Bioactive Materials
Subjects:
Hematopoietic progenitor cells
Collagen
Matrix-dimensionality
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21004084

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