Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus
The marine environment is important yet generally underexplored. It contains new sources of functional constituents that can affect various pathways in food processing, storage, and fortification. Bioactive secondary metabolites produced by marine microorganisms may have significant potential applic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/10/625 |
| _version_ | 1797471900123791360 |
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| author | Sajad Fakhri Sadaf Abdian Seyed Zachariah Moradi Blake E. Delgadillo Carmela Fimognari Anupam Bishayee |
| author_facet | Sajad Fakhri Sadaf Abdian Seyed Zachariah Moradi Blake E. Delgadillo Carmela Fimognari Anupam Bishayee |
| author_sort | Sajad Fakhri |
| collection | DOAJ |
| description | The marine environment is important yet generally underexplored. It contains new sources of functional constituents that can affect various pathways in food processing, storage, and fortification. Bioactive secondary metabolites produced by marine microorganisms may have significant potential applications for humans. Various components isolated from disparate marine microorganisms, including fungi, microalgae, bacteria, and myxomycetes, showed considerable biological effects, such as anticancer, antioxidant, antiviral, antibacterial, and neuroprotective activities. Growing studies are revealing that potential anticancer effects of marine agents could be achieved through the modulation of several organelles. Mitochondria are known organelles that influence growth, differentiation, and death of cells via influencing the biosynthetic, bioenergetic, and various signaling pathways related to oxidative stress and cellular metabolism. Consequently, mitochondria play an essential role in tumorigenesis and cancer treatments by adapting to alterations in environmental and cellular conditions. The growing interest in marine-derived anticancer agents, combined with the development and progression of novel technology in the extraction and cultures of marine life, led to revelations of new compounds with meaningful pharmacological applications. This is the first critical review on marine-derived anticancer agents that have the potential for targeting mitochondrial function during tumorigenesis. This study aims to provide promising strategies in cancer prevention and treatment. |
| first_indexed | 2024-03-09T19:54:38Z |
| format | Article |
| id | doaj.art-f5cba40312744a74bbafdc4449e82d3d |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T19:54:38Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-f5cba40312744a74bbafdc4449e82d3d2023-11-24T01:01:10ZengMDPI AGMarine Drugs1660-33972022-09-01201062510.3390/md20100625Marine Compounds, Mitochondria, and Malignancy: A Therapeutic NexusSajad Fakhri0Sadaf Abdian1Seyed Zachariah Moradi2Blake E. Delgadillo3Carmela Fimognari4Anupam Bishayee5Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, IranStudent Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6714415153, IranPharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, IranCollege of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USADepartment for Life Quality Studies, University of Bologna, 47921 Rimini, ItalyCollege of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USAThe marine environment is important yet generally underexplored. It contains new sources of functional constituents that can affect various pathways in food processing, storage, and fortification. Bioactive secondary metabolites produced by marine microorganisms may have significant potential applications for humans. Various components isolated from disparate marine microorganisms, including fungi, microalgae, bacteria, and myxomycetes, showed considerable biological effects, such as anticancer, antioxidant, antiviral, antibacterial, and neuroprotective activities. Growing studies are revealing that potential anticancer effects of marine agents could be achieved through the modulation of several organelles. Mitochondria are known organelles that influence growth, differentiation, and death of cells via influencing the biosynthetic, bioenergetic, and various signaling pathways related to oxidative stress and cellular metabolism. Consequently, mitochondria play an essential role in tumorigenesis and cancer treatments by adapting to alterations in environmental and cellular conditions. The growing interest in marine-derived anticancer agents, combined with the development and progression of novel technology in the extraction and cultures of marine life, led to revelations of new compounds with meaningful pharmacological applications. This is the first critical review on marine-derived anticancer agents that have the potential for targeting mitochondrial function during tumorigenesis. This study aims to provide promising strategies in cancer prevention and treatment.https://www.mdpi.com/1660-3397/20/10/625marine microorganismsmarine compoundsanticancer activitiesmitochondria |
| spellingShingle | Sajad Fakhri Sadaf Abdian Seyed Zachariah Moradi Blake E. Delgadillo Carmela Fimognari Anupam Bishayee Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus Marine Drugs marine microorganisms marine compounds anticancer activities mitochondria |
| title | Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus |
| title_full | Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus |
| title_fullStr | Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus |
| title_full_unstemmed | Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus |
| title_short | Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus |
| title_sort | marine compounds mitochondria and malignancy a therapeutic nexus |
| topic | marine microorganisms marine compounds anticancer activities mitochondria |
| url | https://www.mdpi.com/1660-3397/20/10/625 |
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