Solid-Phase Synthesis of Amine/Carboxyl Substituted Prolines and Proline Homologues: Scope and Limitations

Solid-Phase Synthesis of Amine/Carboxyl Substituted Prolines and Proline Homologues: Scope and Limitations

A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline or proline homologues variably substituted at the amine and carbonyl sites. The procedure expands the diversity of substituted peptidomimeti...

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Bibliographic Details
Main Authors: Ziniu Zhou, William L. Scott, Martin J. O’Donnell
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Molecules
Subjects:
proline and homologues
piperazine derivatives
peptidomimetics
solid-phase organic synthesis
combinatorial chemistry
Distributed Drug Discovery (D3)
CNS agent.
Online Access:http://www.mdpi.com/1420-3049/21/3/350

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