The Polycyclic Polyprenylated Acylphloroglucinol Antibiotic PPAP 23 Targets the Membrane and Iron Metabolism in Staphylococcus aureus

The Polycyclic Polyprenylated Acylphloroglucinol Antibiotic PPAP 23 Targets the Membrane and Iron Metabolism in Staphylococcus aureus

Recently, a series of endo-type B polycyclic polyprenylated acylphloroglucinols (PPAP) derivatives with high antimicrobial activities were chemically synthesized. One of the derivatives, PPAP 23, which showed high antimicrobial activity and low cytotoxicity, was chosen for further investigation of i...

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Bibliographic Details
Main Authors: Huanhuan Wang, Frank Kraus, Peter Popella, Aslihan Baykal, Claudia Guttroff, Patrice François, Peter Sass, Bernd Plietker, Friedrich Götz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Microbiology
Subjects:
antibiotic
PPAP 23
mode of action
iron metabolism
Staphylococci
MRSA
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00014/full

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