Correlation of “Watch” Antibiotic Consumption with a Gram-negative Bacteria Resistance: Analysis at a Country Level
Introduction: Bacterial antimicrobial resistance (AMR) to the antibiotics (ATB) has severe consequences for human health. The excess ATB consumption is one of the main causes of AMR. One of the World Health Organizations main objective in AMR control strategy is to limit the ATB irrational use, that...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Turkish |
| Published: |
Galenos Yayinevi
2021-12-01
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| Series: | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| Subjects: | |
| Online Access: | http://mjima.org/text.php?&id=296 |
| _version_ | 1828017863867236352 |
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| author | Silvia BONI Gustavo H. MARIN Laura CAMPAÑA Lupe MARIN Gina MARIN Soledad Risso PATRON Fernanda GABRIEL Alejandra CORSO Valeria GARAY Manuel LIMERES |
| author_facet | Silvia BONI Gustavo H. MARIN Laura CAMPAÑA Lupe MARIN Gina MARIN Soledad Risso PATRON Fernanda GABRIEL Alejandra CORSO Valeria GARAY Manuel LIMERES |
| author_sort | Silvia BONI |
| collection | DOAJ |
| description | Introduction: Bacterial antimicrobial resistance (AMR) to the antibiotics (ATB) has severe consequences for human health. The excess ATB consumption is one of the main causes of AMR. One of the World Health Organizations main objective in AMR control strategy is to limit the ATB irrational use, that is why, it proposed to classify the ATB in three groups: “Access”, “Watch”, and “Reserve”, being the latter two preserved for certain situations. The present work aims to know the level of ATB consumption and its correlation with the Gram-negative resistance in Argentina.
Materials and Methods: Gram-negative bacteria resistance to “watch” the ATB groups (cephalosporins/carbapenem/fluoroquinolones) were explored for Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Antibiotic consumption was expressed by the defined daily dose/1000 inhabitants for each ATB for one year period (2018). Resistance/consumption ratio was obtained by calculating the “R” for each region of the country, comparing them with the other countries.
Results: E. coli resistance to 3rd generation cephalosporines was 8.68% and 16.51% in urine (U) and blood (B) samples, respectively, while to carbapenems was 0.08% (U) and 0.36% (B). Resistance of K. pneumoniae to 3 GC was 39.78% (U) and 52.45% (B) while to carbapenem was 9.03% (U) and 17.46% (B). P. aeruginosa resistance to fluoroquinolone and to carbapenems was 29.7% (U)/26.4% (B) and 17.7% (U)/19.9% (B), respectively. The resistance/consumption ratio was heterogenous within the country. Most of the populated areas patterns had similarities with the one observed in the less developed countries (mild-high resistance/mild-high consumption), while the ratio found in less densely populated areas, mimicked countries with the most rational use of ATB.
Conclusion: In Argentina, Gram-negative bacteria showed overall high/mild resistance levels against the “Watch” ATB groups, with a largely variations among each region. |
| first_indexed | 2024-04-10T10:54:51Z |
| format | Article |
| id | doaj.art-f5cf86fe2cad4deab869077de259f9da |
| institution | Directory Open Access Journal |
| issn | 2147-673X |
| language | Turkish |
| last_indexed | 2024-04-10T10:54:51Z |
| publishDate | 2021-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| spelling | doaj.art-f5cf86fe2cad4deab869077de259f9da2023-02-15T16:20:01ZturGalenos YayineviMediterranean Journal of Infection, Microbes and Antimicrobials2147-673X2021-12-0110110.4274/mjima.galenos.2021.2021.67Correlation of “Watch” Antibiotic Consumption with a Gram-negative Bacteria Resistance: Analysis at a Country LevelSilvia BONI0https://orcid.org/0000-0003-2690-7797Gustavo H. MARIN1https://orcid.org/0000-0002-6380-6453Laura CAMPAÑA2https://orcid.org/0000-0002-4131-8934Lupe MARIN3https://orcid.org/0000-0001-5940-0162Gina MARIN4https://orcid.org/0000-0003-3386-3470Soledad Risso PATRON5https://orcid.org/0000-0003-3100-885XFernanda GABRIEL6https://orcid.org/0000-0002-6853-9331Alejandra CORSO7https://orcid.org/0000-0003-1183-6746Valeria GARAY8https://orcid.org/0000-0002-4476-8105Manuel LIMERES9https://orcid.org/0000-0002-5828-5876ANMAT - National Administration of Drugs, Food and Technology of Argentina (National Ministry of Health), Buenos Aires, ArgentinaANMAT - National Administration of Drugs, Food and Technology of Argentina (National Ministry of Health), Buenos Aires, ArgentinaANMAT - National Administration of Drugs, Food and Technology of Argentina (National Ministry of Health), Buenos Aires, ArgentinaUNLP - National University of La Plata-CONICET, Faculty of Medical Science, Buenos Aires, ArgentinaUNLP - National University of La Plata-CONICET, Faculty of Medical Science, Buenos Aires, ArgentinaANMAT - National Administration of Drugs, Food and Technology of Argentina (National Ministry of Health), Buenos Aires, ArgentinaANMAT - National Administration of Drugs, Food and Technology of Argentina (National Ministry of Health), Buenos Aires, ArgentinaANMAT - National Administration of Drugs, Food and Technology of Argentina (National Ministry of Health), Buenos Aires, ArgentinaANMAT - National Administration of Drugs, Food and Technology of Argentina (National Ministry of Health), Buenos Aires, ArgentinaANMAT - National Administration of Drugs, Food and Technology of Argentina (National Ministry of Health), Buenos Aires, ArgentinaIntroduction: Bacterial antimicrobial resistance (AMR) to the antibiotics (ATB) has severe consequences for human health. The excess ATB consumption is one of the main causes of AMR. One of the World Health Organizations main objective in AMR control strategy is to limit the ATB irrational use, that is why, it proposed to classify the ATB in three groups: “Access”, “Watch”, and “Reserve”, being the latter two preserved for certain situations. The present work aims to know the level of ATB consumption and its correlation with the Gram-negative resistance in Argentina. Materials and Methods: Gram-negative bacteria resistance to “watch” the ATB groups (cephalosporins/carbapenem/fluoroquinolones) were explored for Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Antibiotic consumption was expressed by the defined daily dose/1000 inhabitants for each ATB for one year period (2018). Resistance/consumption ratio was obtained by calculating the “R” for each region of the country, comparing them with the other countries. Results: E. coli resistance to 3rd generation cephalosporines was 8.68% and 16.51% in urine (U) and blood (B) samples, respectively, while to carbapenems was 0.08% (U) and 0.36% (B). Resistance of K. pneumoniae to 3 GC was 39.78% (U) and 52.45% (B) while to carbapenem was 9.03% (U) and 17.46% (B). P. aeruginosa resistance to fluoroquinolone and to carbapenems was 29.7% (U)/26.4% (B) and 17.7% (U)/19.9% (B), respectively. The resistance/consumption ratio was heterogenous within the country. Most of the populated areas patterns had similarities with the one observed in the less developed countries (mild-high resistance/mild-high consumption), while the ratio found in less densely populated areas, mimicked countries with the most rational use of ATB. Conclusion: In Argentina, Gram-negative bacteria showed overall high/mild resistance levels against the “Watch” ATB groups, with a largely variations among each region.http://mjima.org/text.php?&id=296gram-negativecephalosporinecarbapenemsfluoroquinolonesresistanceconsumption |
| spellingShingle | Silvia BONI Gustavo H. MARIN Laura CAMPAÑA Lupe MARIN Gina MARIN Soledad Risso PATRON Fernanda GABRIEL Alejandra CORSO Valeria GARAY Manuel LIMERES Correlation of “Watch” Antibiotic Consumption with a Gram-negative Bacteria Resistance: Analysis at a Country Level Mediterranean Journal of Infection, Microbes and Antimicrobials gram-negative cephalosporine carbapenems fluoroquinolones resistance consumption |
| title | Correlation of “Watch” Antibiotic Consumption with a Gram-negative Bacteria Resistance: Analysis at a Country Level |
| title_full | Correlation of “Watch” Antibiotic Consumption with a Gram-negative Bacteria Resistance: Analysis at a Country Level |
| title_fullStr | Correlation of “Watch” Antibiotic Consumption with a Gram-negative Bacteria Resistance: Analysis at a Country Level |
| title_full_unstemmed | Correlation of “Watch” Antibiotic Consumption with a Gram-negative Bacteria Resistance: Analysis at a Country Level |
| title_short | Correlation of “Watch” Antibiotic Consumption with a Gram-negative Bacteria Resistance: Analysis at a Country Level |
| title_sort | correlation of watch antibiotic consumption with a gram negative bacteria resistance analysis at a country level |
| topic | gram-negative cephalosporine carbapenems fluoroquinolones resistance consumption |
| url | http://mjima.org/text.php?&id=296 |
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