Cerebral blood flow changes during intermittent acute hypoxia in patients with heart failure
Objective Heart failure (HF) is associated with intermittent hypoxia, and the effects of this hypoxia on the cardiovascular system are not well understood. This study was performed to compare the effects of acute hypoxia (10% oxygen) between patients with and without HF. Methods Fourteen patients wi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-10-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060518791691 |
| _version_ | 1819024922710638592 |
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| author | Antonio P. Mansur Glaura Souza Alvarenga Liliane Kopel Marco Antonio Gutierrez Fernanda Marciano Consolim-Colombo Ludhmila Hajjar Abrahão Silvia Gelas Lage |
| author_facet | Antonio P. Mansur Glaura Souza Alvarenga Liliane Kopel Marco Antonio Gutierrez Fernanda Marciano Consolim-Colombo Ludhmila Hajjar Abrahão Silvia Gelas Lage |
| author_sort | Antonio P. Mansur |
| collection | DOAJ |
| description | Objective Heart failure (HF) is associated with intermittent hypoxia, and the effects of this hypoxia on the cardiovascular system are not well understood. This study was performed to compare the effects of acute hypoxia (10% oxygen) between patients with and without HF. Methods Fourteen patients with chronic HF and 17 matched control subjects were enrolled. Carotid artery changes were examined during the first period of hypoxia, and brachial artery changes were examined during the second period of hypoxia. Data were collected at baseline and after 2 and 4 minutes of hypoxia. Norepinephrine, epinephrine, dopamine, and renin were measured at baseline and after 4 minutes hypoxia. Results The carotid blood flow, carotid systolic diameter, and carotid diastolic diameter increased and the carotid resistance decreased in patients with HF. Hypoxia did not change the carotid compliance, distensibility, brachial artery blood flow and diameter, or concentrations of sympathomimetic amines in patients with HF, but hypoxia increased the norepinephrine level in the control group. Hypoxia increased minute ventilation and decreased the oxygen saturation and end-tidal carbon dioxide concentration in both groups. Conclusion Hypoxia-induced changes in the carotid artery suggest an intensification of compensatory mechanisms for preservation of cerebral blood flow in patients with HF. |
| first_indexed | 2024-12-21T05:02:29Z |
| format | Article |
| id | doaj.art-f5d23301f68643849c6d7094503740d4 |
| institution | Directory Open Access Journal |
| issn | 0300-0605 1473-2300 |
| language | English |
| last_indexed | 2024-12-21T05:02:29Z |
| publishDate | 2018-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-f5d23301f68643849c6d7094503740d42022-12-21T19:15:13ZengSAGE PublishingJournal of International Medical Research0300-06051473-23002018-10-014610.1177/0300060518791691Cerebral blood flow changes during intermittent acute hypoxia in patients with heart failureAntonio P. MansurGlaura Souza AlvarengaLiliane KopelMarco Antonio GutierrezFernanda Marciano Consolim-ColomboLudhmila Hajjar Abrahão Silvia Gelas LageObjective Heart failure (HF) is associated with intermittent hypoxia, and the effects of this hypoxia on the cardiovascular system are not well understood. This study was performed to compare the effects of acute hypoxia (10% oxygen) between patients with and without HF. Methods Fourteen patients with chronic HF and 17 matched control subjects were enrolled. Carotid artery changes were examined during the first period of hypoxia, and brachial artery changes were examined during the second period of hypoxia. Data were collected at baseline and after 2 and 4 minutes of hypoxia. Norepinephrine, epinephrine, dopamine, and renin were measured at baseline and after 4 minutes hypoxia. Results The carotid blood flow, carotid systolic diameter, and carotid diastolic diameter increased and the carotid resistance decreased in patients with HF. Hypoxia did not change the carotid compliance, distensibility, brachial artery blood flow and diameter, or concentrations of sympathomimetic amines in patients with HF, but hypoxia increased the norepinephrine level in the control group. Hypoxia increased minute ventilation and decreased the oxygen saturation and end-tidal carbon dioxide concentration in both groups. Conclusion Hypoxia-induced changes in the carotid artery suggest an intensification of compensatory mechanisms for preservation of cerebral blood flow in patients with HF.https://doi.org/10.1177/0300060518791691 |
| spellingShingle | Antonio P. Mansur Glaura Souza Alvarenga Liliane Kopel Marco Antonio Gutierrez Fernanda Marciano Consolim-Colombo Ludhmila Hajjar Abrahão Silvia Gelas Lage Cerebral blood flow changes during intermittent acute hypoxia in patients with heart failure Journal of International Medical Research |
| title | Cerebral blood flow changes during intermittent acute hypoxia in patients with heart failure |
| title_full | Cerebral blood flow changes during intermittent acute hypoxia in patients with heart failure |
| title_fullStr | Cerebral blood flow changes during intermittent acute hypoxia in patients with heart failure |
| title_full_unstemmed | Cerebral blood flow changes during intermittent acute hypoxia in patients with heart failure |
| title_short | Cerebral blood flow changes during intermittent acute hypoxia in patients with heart failure |
| title_sort | cerebral blood flow changes during intermittent acute hypoxia in patients with heart failure |
| url | https://doi.org/10.1177/0300060518791691 |
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