Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans.
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced lon...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3723528?pdf=render |
| _version_ | 1819016639076630528 |
|---|---|
| author | Bree N Heestand Yidong Shen Wei Liu Daniel B Magner Nadia Storm Caroline Meharg Bianca Habermann Adam Antebi |
| author_facet | Bree N Heestand Yidong Shen Wei Liu Daniel B Magner Nadia Storm Caroline Meharg Bianca Habermann Adam Antebi |
| author_sort | Bree N Heestand |
| collection | DOAJ |
| description | Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels. Metabolic changes associated with DR, including decreased Oil Red O staining, decreased triglyceride levels, and increased autophagy are partly reversed by mutation of nhr-62. Additionally, the DR fatty acid profile is altered in nhr-62 mutants. Expression profiles reveal that several hundred genes induced by DR depend on the activity of NHR-62, including a putative lipase required for the DR response. This study provides critical evidence of nuclear hormone receptor regulation of the DR longevity response, suggesting hormonal and metabolic control of life span. |
| first_indexed | 2024-12-21T02:50:49Z |
| format | Article |
| id | doaj.art-f5d500f3dcd848a5bc9c5dec3d755b57 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-21T02:50:49Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-f5d500f3dcd848a5bc9c5dec3d755b572022-12-21T19:18:27ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042013-01-0197e100365110.1371/journal.pgen.1003651Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans.Bree N HeestandYidong ShenWei LiuDaniel B MagnerNadia StormCaroline MehargBianca HabermannAdam AntebiDietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels. Metabolic changes associated with DR, including decreased Oil Red O staining, decreased triglyceride levels, and increased autophagy are partly reversed by mutation of nhr-62. Additionally, the DR fatty acid profile is altered in nhr-62 mutants. Expression profiles reveal that several hundred genes induced by DR depend on the activity of NHR-62, including a putative lipase required for the DR response. This study provides critical evidence of nuclear hormone receptor regulation of the DR longevity response, suggesting hormonal and metabolic control of life span.http://europepmc.org/articles/PMC3723528?pdf=render |
| spellingShingle | Bree N Heestand Yidong Shen Wei Liu Daniel B Magner Nadia Storm Caroline Meharg Bianca Habermann Adam Antebi Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genetics |
| title | Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. |
| title_full | Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. |
| title_fullStr | Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. |
| title_full_unstemmed | Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. |
| title_short | Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. |
| title_sort | dietary restriction induced longevity is mediated by nuclear receptor nhr 62 in caenorhabditis elegans |
| url | http://europepmc.org/articles/PMC3723528?pdf=render |
| work_keys_str_mv | AT breenheestand dietaryrestrictioninducedlongevityismediatedbynuclearreceptornhr62incaenorhabditiselegans AT yidongshen dietaryrestrictioninducedlongevityismediatedbynuclearreceptornhr62incaenorhabditiselegans AT weiliu dietaryrestrictioninducedlongevityismediatedbynuclearreceptornhr62incaenorhabditiselegans AT danielbmagner dietaryrestrictioninducedlongevityismediatedbynuclearreceptornhr62incaenorhabditiselegans AT nadiastorm dietaryrestrictioninducedlongevityismediatedbynuclearreceptornhr62incaenorhabditiselegans AT carolinemeharg dietaryrestrictioninducedlongevityismediatedbynuclearreceptornhr62incaenorhabditiselegans AT biancahabermann dietaryrestrictioninducedlongevityismediatedbynuclearreceptornhr62incaenorhabditiselegans AT adamantebi dietaryrestrictioninducedlongevityismediatedbynuclearreceptornhr62incaenorhabditiselegans |