The protein expression profile of ACE2 in human tissues

Abstract The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cel...

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Main Authors: Feria Hikmet, Loren Méar, Åsa Edvinsson, Patrick Micke, Mathias Uhlén, Cecilia Lindskog
Format: Article
Language:English
Published: Springer Nature 2020-07-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.15252/msb.20209610
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author Feria Hikmet
Loren Méar
Åsa Edvinsson
Patrick Micke
Mathias Uhlén
Cecilia Lindskog
author_facet Feria Hikmet
Loren Méar
Åsa Edvinsson
Patrick Micke
Mathias Uhlén
Cecilia Lindskog
author_sort Feria Hikmet
collection DOAJ
description Abstract The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS‐CoV‐2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.
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spelling doaj.art-f5d5dba5788b429784539a564117f4762024-03-02T22:21:37ZengSpringer NatureMolecular Systems Biology1744-42922020-07-01167n/an/a10.15252/msb.20209610The protein expression profile of ACE2 in human tissuesFeria Hikmet0Loren Méar1Åsa Edvinsson2Patrick Micke3Mathias Uhlén4Cecilia Lindskog5Rudbeck Laboratory Department of Immunology, Genetics and Pathology Uppsala University Uppsala SwedenRudbeck Laboratory Department of Immunology, Genetics and Pathology Uppsala University Uppsala SwedenRudbeck Laboratory Department of Immunology, Genetics and Pathology Uppsala University Uppsala SwedenRudbeck Laboratory Department of Immunology, Genetics and Pathology Uppsala University Uppsala SwedenScience for Life Laboratory School of Engineering Sciences in Chemistry, Biotechnology and Health KTH ‐ Royal Institute of Technology Stockholm SwedenRudbeck Laboratory Department of Immunology, Genetics and Pathology Uppsala University Uppsala SwedenAbstract The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS‐CoV‐2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.https://doi.org/10.15252/msb.20209610ACE2immunohistochemistryrespiratory systemSARS‐CoV-2transcriptomics
spellingShingle Feria Hikmet
Loren Méar
Åsa Edvinsson
Patrick Micke
Mathias Uhlén
Cecilia Lindskog
The protein expression profile of ACE2 in human tissues
Molecular Systems Biology
ACE2
immunohistochemistry
respiratory system
SARS‐CoV-2
transcriptomics
title The protein expression profile of ACE2 in human tissues
title_full The protein expression profile of ACE2 in human tissues
title_fullStr The protein expression profile of ACE2 in human tissues
title_full_unstemmed The protein expression profile of ACE2 in human tissues
title_short The protein expression profile of ACE2 in human tissues
title_sort protein expression profile of ace2 in human tissues
topic ACE2
immunohistochemistry
respiratory system
SARS‐CoV-2
transcriptomics
url https://doi.org/10.15252/msb.20209610
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