The protein expression profile of ACE2 in human tissues
Abstract The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cel...
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Format: | Article |
Language: | English |
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Springer Nature
2020-07-01
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Series: | Molecular Systems Biology |
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Online Access: | https://doi.org/10.15252/msb.20209610 |
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author | Feria Hikmet Loren Méar Åsa Edvinsson Patrick Micke Mathias Uhlén Cecilia Lindskog |
author_facet | Feria Hikmet Loren Méar Åsa Edvinsson Patrick Micke Mathias Uhlén Cecilia Lindskog |
author_sort | Feria Hikmet |
collection | DOAJ |
description | Abstract The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS‐CoV‐2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection. |
first_indexed | 2024-03-07T17:16:19Z |
format | Article |
id | doaj.art-f5d5dba5788b429784539a564117f476 |
institution | Directory Open Access Journal |
issn | 1744-4292 |
language | English |
last_indexed | 2024-03-07T17:16:19Z |
publishDate | 2020-07-01 |
publisher | Springer Nature |
record_format | Article |
series | Molecular Systems Biology |
spelling | doaj.art-f5d5dba5788b429784539a564117f4762024-03-02T22:21:37ZengSpringer NatureMolecular Systems Biology1744-42922020-07-01167n/an/a10.15252/msb.20209610The protein expression profile of ACE2 in human tissuesFeria Hikmet0Loren Méar1Åsa Edvinsson2Patrick Micke3Mathias Uhlén4Cecilia Lindskog5Rudbeck Laboratory Department of Immunology, Genetics and Pathology Uppsala University Uppsala SwedenRudbeck Laboratory Department of Immunology, Genetics and Pathology Uppsala University Uppsala SwedenRudbeck Laboratory Department of Immunology, Genetics and Pathology Uppsala University Uppsala SwedenRudbeck Laboratory Department of Immunology, Genetics and Pathology Uppsala University Uppsala SwedenScience for Life Laboratory School of Engineering Sciences in Chemistry, Biotechnology and Health KTH ‐ Royal Institute of Technology Stockholm SwedenRudbeck Laboratory Department of Immunology, Genetics and Pathology Uppsala University Uppsala SwedenAbstract The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS‐CoV‐2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.https://doi.org/10.15252/msb.20209610ACE2immunohistochemistryrespiratory systemSARS‐CoV-2transcriptomics |
spellingShingle | Feria Hikmet Loren Méar Åsa Edvinsson Patrick Micke Mathias Uhlén Cecilia Lindskog The protein expression profile of ACE2 in human tissues Molecular Systems Biology ACE2 immunohistochemistry respiratory system SARS‐CoV-2 transcriptomics |
title | The protein expression profile of ACE2 in human tissues |
title_full | The protein expression profile of ACE2 in human tissues |
title_fullStr | The protein expression profile of ACE2 in human tissues |
title_full_unstemmed | The protein expression profile of ACE2 in human tissues |
title_short | The protein expression profile of ACE2 in human tissues |
title_sort | protein expression profile of ace2 in human tissues |
topic | ACE2 immunohistochemistry respiratory system SARS‐CoV-2 transcriptomics |
url | https://doi.org/10.15252/msb.20209610 |
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