Phylogenetic Investigations of Dengue 2019–2021 Outbreak in Guadeloupe and Martinique Caribbean Islands
Dengue fever has been a public health problem in the Caribbean region since 1981, when it first reappeared in Cuba. In 1989, it was reported in Martinique and Guadeloupe (two French islands 200 km apart); since then, DENV has caused several epidemics locally. In 2019–2021, DENV-1, DENV-2, and DENV-3...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/9/1182 |
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| author | Margot Garcia--Van Smévoorde Géraldine Piorkowski Loic Emboulé Georges Dos Santos Cécile Loraux Stéphanie Guyomard-Rabenirina Marie-Odile Joannes Laurence Fagour Fatiha Najioullah André Cabié Xavier de Lamballerie Anubis Vega-Rúa Raymond Césaire Elodie Calvez |
| author_facet | Margot Garcia--Van Smévoorde Géraldine Piorkowski Loic Emboulé Georges Dos Santos Cécile Loraux Stéphanie Guyomard-Rabenirina Marie-Odile Joannes Laurence Fagour Fatiha Najioullah André Cabié Xavier de Lamballerie Anubis Vega-Rúa Raymond Césaire Elodie Calvez |
| author_sort | Margot Garcia--Van Smévoorde |
| collection | DOAJ |
| description | Dengue fever has been a public health problem in the Caribbean region since 1981, when it first reappeared in Cuba. In 1989, it was reported in Martinique and Guadeloupe (two French islands 200 km apart); since then, DENV has caused several epidemics locally. In 2019–2021, DENV-1, DENV-2, and DENV-3 were detected. Serotype distribution was differentiated, with DENV-2 and DENV-3 predominating in Guadeloupe and Martinique, respectively. Complete genome sequencing was carried out on 32 specimens, and phylogenic analysis identified the circulation of genotype V for DENV-1, cosmopolitan genotype for DENV-2, and genotype III for DENV-3. However, two distinct circulating groups were identified for DENV-1 and DENV-3, suggesting independent introductions. Overall, despite the context of the COVID-19 pandemic and the associated travel restrictions, these results confirm the active circulation of DENV and specific epidemiological features on each of the two islands. Such differences may be linked to the founder effect of the various introduction events, and to local factors such as the population immunity and the transmission capacity of the vectors. Further genomic and epidemiological characterization of DENV strains remains essential to understand how dengue spreads in each specific geographical context and to prevent future epidemics. |
| first_indexed | 2024-03-10T22:17:57Z |
| format | Article |
| id | doaj.art-f5d644b102de49ae9d17df2af3fc8734 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T22:17:57Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-f5d644b102de49ae9d17df2af3fc87342023-11-19T12:23:15ZengMDPI AGPathogens2076-08172023-09-01129118210.3390/pathogens12091182Phylogenetic Investigations of Dengue 2019–2021 Outbreak in Guadeloupe and Martinique Caribbean IslandsMargot Garcia--Van Smévoorde0Géraldine Piorkowski1Loic Emboulé2Georges Dos Santos3Cécile Loraux4Stéphanie Guyomard-Rabenirina5Marie-Odile Joannes6Laurence Fagour7Fatiha Najioullah8André Cabié9Xavier de Lamballerie10Anubis Vega-Rúa11Raymond Césaire12Elodie Calvez13Vector Control Research Laboratory, Transmission Reservoir and Pathogens Diversity Unit, Institut Pasteur de la Guadeloupe, Les Abymes 97139, GuadeloupeUnité des Virus Emergents (UVE), Aix-Marseille Univ-IRD 190-Inserm 1207, 13005 Marseille, FranceMolecular Genetics and Inherited Red Blood Cell Diseases Laboratory, University Hospitals of Guadeloupe, Pointe-à-Pitre 97159, GuadeloupeDepartment of Virology, University Hospitals of Martinique, Fort-de-France, 97200 Martinique, FranceDepartment of Virology, University Hospitals of Guadeloupe, Pointe-à-Pitre 97159, GuadeloupeMicrobial Ecosystems Interaction Laboratory, Transmission Reservoir and Pathogens Diversity Unit, Institut Pasteur de la Guadeloupe, Les Abymes 97139, GuadeloupeDepartment of Hematology Immunology Histocompatibility, University Hospitals of Guadeloupe, Pointe-à-Pitre 97159, GuadeloupeDepartment of Virology, University Hospitals of Martinique, Fort-de-France, 97200 Martinique, FranceDepartment of Clinical Research and Innovation, University Hospitals of Martinique, Fort-de-France, 97200 Martinique, FrancePathogenesis and Controle of Chronic and Emerging Infections, French National Blood Service (EFS), National Institute of Health and Medical Research (Inserm), University of Montpellier, 34000 Montpellier, FranceUnité des Virus Emergents (UVE), Aix-Marseille Univ-IRD 190-Inserm 1207, 13005 Marseille, FranceVector Control Research Laboratory, Transmission Reservoir and Pathogens Diversity Unit, Institut Pasteur de la Guadeloupe, Les Abymes 97139, GuadeloupePathogenesis and Controle of Chronic and Emerging Infections, French National Blood Service (EFS), National Institute of Health and Medical Research (Inserm), University of Montpellier, 34000 Montpellier, FranceVector Control Research Laboratory, Transmission Reservoir and Pathogens Diversity Unit, Institut Pasteur de la Guadeloupe, Les Abymes 97139, GuadeloupeDengue fever has been a public health problem in the Caribbean region since 1981, when it first reappeared in Cuba. In 1989, it was reported in Martinique and Guadeloupe (two French islands 200 km apart); since then, DENV has caused several epidemics locally. In 2019–2021, DENV-1, DENV-2, and DENV-3 were detected. Serotype distribution was differentiated, with DENV-2 and DENV-3 predominating in Guadeloupe and Martinique, respectively. Complete genome sequencing was carried out on 32 specimens, and phylogenic analysis identified the circulation of genotype V for DENV-1, cosmopolitan genotype for DENV-2, and genotype III for DENV-3. However, two distinct circulating groups were identified for DENV-1 and DENV-3, suggesting independent introductions. Overall, despite the context of the COVID-19 pandemic and the associated travel restrictions, these results confirm the active circulation of DENV and specific epidemiological features on each of the two islands. Such differences may be linked to the founder effect of the various introduction events, and to local factors such as the population immunity and the transmission capacity of the vectors. Further genomic and epidemiological characterization of DENV strains remains essential to understand how dengue spreads in each specific geographical context and to prevent future epidemics.https://www.mdpi.com/2076-0817/12/9/1182dengueoutbreakphylogenyGuadeloupeMartiniqueCaribbean |
| spellingShingle | Margot Garcia--Van Smévoorde Géraldine Piorkowski Loic Emboulé Georges Dos Santos Cécile Loraux Stéphanie Guyomard-Rabenirina Marie-Odile Joannes Laurence Fagour Fatiha Najioullah André Cabié Xavier de Lamballerie Anubis Vega-Rúa Raymond Césaire Elodie Calvez Phylogenetic Investigations of Dengue 2019–2021 Outbreak in Guadeloupe and Martinique Caribbean Islands Pathogens dengue outbreak phylogeny Guadeloupe Martinique Caribbean |
| title | Phylogenetic Investigations of Dengue 2019–2021 Outbreak in Guadeloupe and Martinique Caribbean Islands |
| title_full | Phylogenetic Investigations of Dengue 2019–2021 Outbreak in Guadeloupe and Martinique Caribbean Islands |
| title_fullStr | Phylogenetic Investigations of Dengue 2019–2021 Outbreak in Guadeloupe and Martinique Caribbean Islands |
| title_full_unstemmed | Phylogenetic Investigations of Dengue 2019–2021 Outbreak in Guadeloupe and Martinique Caribbean Islands |
| title_short | Phylogenetic Investigations of Dengue 2019–2021 Outbreak in Guadeloupe and Martinique Caribbean Islands |
| title_sort | phylogenetic investigations of dengue 2019 2021 outbreak in guadeloupe and martinique caribbean islands |
| topic | dengue outbreak phylogeny Guadeloupe Martinique Caribbean |
| url | https://www.mdpi.com/2076-0817/12/9/1182 |
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