De Novo Synthesis of Polysubstituted 3-Hydroxypyridines Via “Anti-Wacker”-Type Cyclization

De Novo Synthesis of Polysubstituted 3-Hydroxypyridines Via “Anti-Wacker”-Type Cyclization

We report an efficient method to prepare polysubstituted 3-hydroxypyridines from amino acids, propargyl alcohols, and arylboronic acids. The process involves Pd(0)-catalyzed <i>anti</i>-selective arylative cyclizations of <i>N</i>-propargyl-<i>N</i>-tosyl-aminoald...

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Bibliographic Details
Main Authors:	Kazuya Ito, Takayuki Doi, Hirokazu Tsukamoto
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Catalysts
Subjects:	“anti-Wacker”-type cyclization 3-hydroxypyridine arylboronic acids palladium amino acids propargyl alcohols
Online Access:	https://www.mdpi.com/2073-4344/13/2/319

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