Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric Cancer
Over the last decade, researchers have found abnormal expression of transient receptor potential (TRP) channels. In particular, members of the thermally sensitive subclass (thermo-TRPs) are involved in many disease processes. Moreover, they have a vital role in the occurrence and development of gast...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/23/15289 |
| _version_ | 1797463041615331328 |
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| author | Gang-Fan Zong Rui Deng Su-Yun Yu Ai-Yun Wang Zhong-Hong Wei Yang Zhao Yin Lu |
| author_facet | Gang-Fan Zong Rui Deng Su-Yun Yu Ai-Yun Wang Zhong-Hong Wei Yang Zhao Yin Lu |
| author_sort | Gang-Fan Zong |
| collection | DOAJ |
| description | Over the last decade, researchers have found abnormal expression of transient receptor potential (TRP) channels. In particular, members of the thermally sensitive subclass (thermo-TRPs) are involved in many disease processes. Moreover, they have a vital role in the occurrence and development of gastric cancer (GC). Accordingly, thermo-TRPs constitute a major pharmacological target, and the elucidation of the mechanisms underlying their response to physiological stimuli or drugs is key for notable advances in GC treatment. Therefore, this paper summarizes the existing literature about thermo-TRP protein expression changes that are linked to the incidence and progression of GC. The review also discusses the implication of such association to pathology and cell physiology and identifies potential thermo-TRP protein targets for diagnosis and treatment of GC. |
| first_indexed | 2024-03-09T17:45:04Z |
| format | Article |
| id | doaj.art-f5d6a5397fef43d18eb864bb91d1d9b1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T17:45:04Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f5d6a5397fef43d18eb864bb91d1d9b12023-11-24T11:16:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123231528910.3390/ijms232315289Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric CancerGang-Fan Zong0Rui Deng1Su-Yun Yu2Ai-Yun Wang3Zhong-Hong Wei4Yang Zhao5Yin Lu6Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, No.138 Xianlin Avenue, Nanjing 210023, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaOver the last decade, researchers have found abnormal expression of transient receptor potential (TRP) channels. In particular, members of the thermally sensitive subclass (thermo-TRPs) are involved in many disease processes. Moreover, they have a vital role in the occurrence and development of gastric cancer (GC). Accordingly, thermo-TRPs constitute a major pharmacological target, and the elucidation of the mechanisms underlying their response to physiological stimuli or drugs is key for notable advances in GC treatment. Therefore, this paper summarizes the existing literature about thermo-TRP protein expression changes that are linked to the incidence and progression of GC. The review also discusses the implication of such association to pathology and cell physiology and identifies potential thermo-TRP protein targets for diagnosis and treatment of GC.https://www.mdpi.com/1422-0067/23/23/15289TRPtemperaturegastric cancerion channeltherapeutic target |
| spellingShingle | Gang-Fan Zong Rui Deng Su-Yun Yu Ai-Yun Wang Zhong-Hong Wei Yang Zhao Yin Lu Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric Cancer International Journal of Molecular Sciences TRP temperature gastric cancer ion channel therapeutic target |
| title | Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric Cancer |
| title_full | Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric Cancer |
| title_fullStr | Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric Cancer |
| title_full_unstemmed | Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric Cancer |
| title_short | Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric Cancer |
| title_sort | thermo transient receptor potential channels therapeutic potential in gastric cancer |
| topic | TRP temperature gastric cancer ion channel therapeutic target |
| url | https://www.mdpi.com/1422-0067/23/23/15289 |
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