The Diverse Role of CUB and Sushi Multiple Domains 1 (CSMD1) in Human Diseases
CUB and Sushi Multiple Domains 1 (<i>CSMD1</i>), a tumour suppressor gene, encodes a large membrane-bound protein including a single transmembrane domain. This transmembrane region has a potential tyrosine phosphorylation site, suggesting that CSMD1 is involved in controlling cellular fu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/12/2332 |
| _version_ | 1797457871343976448 |
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| author | Esra Ermis Akyuz Sandra M. Bell |
| author_facet | Esra Ermis Akyuz Sandra M. Bell |
| author_sort | Esra Ermis Akyuz |
| collection | DOAJ |
| description | CUB and Sushi Multiple Domains 1 (<i>CSMD1</i>), a tumour suppressor gene, encodes a large membrane-bound protein including a single transmembrane domain. This transmembrane region has a potential tyrosine phosphorylation site, suggesting that CSMD1 is involved in controlling cellular functions. Although the specific mechanisms of action for CSMD1 have not yet been uncovered, it has been linked to a number of processes including development, complement control, neurodevelopment, and cancer progression. In this review, we summarise CSMD1 functions in the cellular processes involved in the complement system, metastasis, and Epithelial mesenchymal transition (EMT) and also in the diseases schizophrenia, Parkinson’s disease, and cancer. Clarifying the association between CSMD1 and the aforementioned diseases will contribute to the development of new diagnosis and treatment methods for these diseases. Recent studies in certain cancer types, e.g., gastric cancer, oesophageal cancer, and head and neck squamous cell carcinomas, have indicated the involvement of CSMD1 in response to immunotherapy. |
| first_indexed | 2024-03-09T16:28:59Z |
| format | Article |
| id | doaj.art-f5d6a66decf041de9b7e4aea30fa672e |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T16:28:59Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-f5d6a66decf041de9b7e4aea30fa672e2023-11-24T15:05:07ZengMDPI AGGenes2073-44252022-12-011312233210.3390/genes13122332The Diverse Role of CUB and Sushi Multiple Domains 1 (CSMD1) in Human DiseasesEsra Ermis Akyuz0Sandra M. Bell1Division of Molecular Medicine, Leeds Institute of Medical Research, St James’s University Hospital, University of Leeds, Leeds LS9 7TF, UKDivision of Molecular Medicine, Leeds Institute of Medical Research, St James’s University Hospital, University of Leeds, Leeds LS9 7TF, UKCUB and Sushi Multiple Domains 1 (<i>CSMD1</i>), a tumour suppressor gene, encodes a large membrane-bound protein including a single transmembrane domain. This transmembrane region has a potential tyrosine phosphorylation site, suggesting that CSMD1 is involved in controlling cellular functions. Although the specific mechanisms of action for CSMD1 have not yet been uncovered, it has been linked to a number of processes including development, complement control, neurodevelopment, and cancer progression. In this review, we summarise CSMD1 functions in the cellular processes involved in the complement system, metastasis, and Epithelial mesenchymal transition (EMT) and also in the diseases schizophrenia, Parkinson’s disease, and cancer. Clarifying the association between CSMD1 and the aforementioned diseases will contribute to the development of new diagnosis and treatment methods for these diseases. Recent studies in certain cancer types, e.g., gastric cancer, oesophageal cancer, and head and neck squamous cell carcinomas, have indicated the involvement of CSMD1 in response to immunotherapy.https://www.mdpi.com/2073-4425/13/12/2332CSMD1cancercomplement systemschizophreniaParkinson’s disease |
| spellingShingle | Esra Ermis Akyuz Sandra M. Bell The Diverse Role of CUB and Sushi Multiple Domains 1 (CSMD1) in Human Diseases Genes CSMD1 cancer complement system schizophrenia Parkinson’s disease |
| title | The Diverse Role of CUB and Sushi Multiple Domains 1 (CSMD1) in Human Diseases |
| title_full | The Diverse Role of CUB and Sushi Multiple Domains 1 (CSMD1) in Human Diseases |
| title_fullStr | The Diverse Role of CUB and Sushi Multiple Domains 1 (CSMD1) in Human Diseases |
| title_full_unstemmed | The Diverse Role of CUB and Sushi Multiple Domains 1 (CSMD1) in Human Diseases |
| title_short | The Diverse Role of CUB and Sushi Multiple Domains 1 (CSMD1) in Human Diseases |
| title_sort | diverse role of cub and sushi multiple domains 1 csmd1 in human diseases |
| topic | CSMD1 cancer complement system schizophrenia Parkinson’s disease |
| url | https://www.mdpi.com/2073-4425/13/12/2332 |
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