Treatment for recurrent HCV infection after liver transplantation for final stages of chronic hepatitis С
The review discusses whether antiviral therapy for recurrent hepatitis C virus (HCV) infection may be used following liver transplantation. It analyzes the concepts of pre-emptive therapy initiated within the first weeks after the transplantation, as well as therapy for histologically verified activ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2018-08-01
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| Series: | Трансплантология (Москва) |
| Subjects: | |
| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/277 |
| _version_ | 1826564644191338496 |
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| author | V. E. Syutkin O. I. Andreitseva A. V. Kozlova |
| author_facet | V. E. Syutkin O. I. Andreitseva A. V. Kozlova |
| author_sort | V. E. Syutkin |
| collection | DOAJ |
| description | The review discusses whether antiviral therapy for recurrent hepatitis C virus (HCV) infection may be used following liver transplantation. It analyzes the concepts of pre-emptive therapy initiated within the first weeks after the transplantation, as well as therapy for histologically verified active hepatitis and/or liver fibrosis. Capabilities and limits in the use of pegylated interferons and ribavirin as monotherapy or combination therapy are considered. Particular emphasis is placed on the role of viral kinetics in the determination of the duration of further therapy, including the possibility of its prolongation up to > 12 months. There are arguments in favor of a better course of recurrent HCV infection in patients receiving cyclosporine versus those taking tacrolimus. |
| first_indexed | 2024-03-12T18:43:18Z |
| format | Article |
| id | doaj.art-f5d9b42c5ca849a0817450ad9c48aba2 |
| institution | Directory Open Access Journal |
| issn | 2074-0506 2542-0909 |
| language | English |
| last_indexed | 2025-03-14T10:23:08Z |
| publishDate | 2018-08-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj.art-f5d9b42c5ca849a0817450ad9c48aba22025-03-02T11:07:32ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092018-08-0102101710.23873/2074-0506-2010-0-2-10-17266Treatment for recurrent HCV infection after liver transplantation for final stages of chronic hepatitis СV. E. Syutkin0O. I. Andreitseva1A. V. Kozlova2N.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareThe review discusses whether antiviral therapy for recurrent hepatitis C virus (HCV) infection may be used following liver transplantation. It analyzes the concepts of pre-emptive therapy initiated within the first weeks after the transplantation, as well as therapy for histologically verified active hepatitis and/or liver fibrosis. Capabilities and limits in the use of pegylated interferons and ribavirin as monotherapy or combination therapy are considered. Particular emphasis is placed on the role of viral kinetics in the determination of the duration of further therapy, including the possibility of its prolongation up to > 12 months. There are arguments in favor of a better course of recurrent HCV infection in patients receiving cyclosporine versus those taking tacrolimus.https://www.jtransplantologiya.ru/jour/article/view/277chronic hepatitis cpegylated interferonribavirincyclosporineliver transplantation |
| spellingShingle | V. E. Syutkin O. I. Andreitseva A. V. Kozlova Treatment for recurrent HCV infection after liver transplantation for final stages of chronic hepatitis С Трансплантология (Москва) chronic hepatitis c pegylated interferon ribavirin cyclosporine liver transplantation |
| title | Treatment for recurrent HCV infection after liver transplantation for final stages of chronic hepatitis С |
| title_full | Treatment for recurrent HCV infection after liver transplantation for final stages of chronic hepatitis С |
| title_fullStr | Treatment for recurrent HCV infection after liver transplantation for final stages of chronic hepatitis С |
| title_full_unstemmed | Treatment for recurrent HCV infection after liver transplantation for final stages of chronic hepatitis С |
| title_short | Treatment for recurrent HCV infection after liver transplantation for final stages of chronic hepatitis С |
| title_sort | treatment for recurrent hcv infection after liver transplantation for final stages of chronic hepatitis с |
| topic | chronic hepatitis c pegylated interferon ribavirin cyclosporine liver transplantation |
| url | https://www.jtransplantologiya.ru/jour/article/view/277 |
| work_keys_str_mv | AT vesyutkin treatmentforrecurrenthcvinfectionafterlivertransplantationforfinalstagesofchronichepatitiss AT oiandreitseva treatmentforrecurrenthcvinfectionafterlivertransplantationforfinalstagesofchronichepatitiss AT avkozlova treatmentforrecurrenthcvinfectionafterlivertransplantationforfinalstagesofchronichepatitiss |