Deaths during tuberculosis treatment among paediatric patients in a large tertiary hospital in Nigeria.
Despite availability of effective cure, tuberculosis (TB) remains a leading cause of death in children. In many high-burden countries, childhood TB is underdiagnosed and underreported, and care is often accessed too late, resulting in adverse treatment outcomes. In this study, we examined the time t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5560640?pdf=render |
| _version_ | 1819051986897600512 |
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| author | Aishatu L Adamu Muktar H Aliyu Najiba Aliyu Galadanci Baba Maiyaki Musa Muktar A Gadanya Auwalu U Gajida Taiwo G Amole Imam W Bello Safiya Gambo Ibrahim Abubakar |
| author_facet | Aishatu L Adamu Muktar H Aliyu Najiba Aliyu Galadanci Baba Maiyaki Musa Muktar A Gadanya Auwalu U Gajida Taiwo G Amole Imam W Bello Safiya Gambo Ibrahim Abubakar |
| author_sort | Aishatu L Adamu |
| collection | DOAJ |
| description | Despite availability of effective cure, tuberculosis (TB) remains a leading cause of death in children. In many high-burden countries, childhood TB is underdiagnosed and underreported, and care is often accessed too late, resulting in adverse treatment outcomes. In this study, we examined the time to death and its associated factors among a cohort of children that commenced TB treatment in a large treatment centre in northern Nigeria.This is a retrospective cohort study of children that started TB treatment between 2010 and 2014. We determined mortality rates per 100 person-months of treatment, as well as across treatment and calendar periods. We used Cox proportional hazards regression to determine adjusted hazard ratios (aHR) for factors associated with mortality.Among 299 children with a median age 4 years and HIV prevalence of 33.4%; 85 (28.4%) died after 1,383 months of follow-up. Overall mortality rate was 6.1 per 100 person-months. Deaths occurred early during treatment and declined from 42.4 per 100 person-months in the 1st week of treatment to 2.2 per 100 person-months after at the 3rd month of treatment. Mortality was highest between October to December period (9.1 per 100 pm) and lowest between July and September (2.8 per 100 pm). Risk factors for mortality included previous TB treatment (aHR 2.04:95%CI;1.09-3.84); HIV infection (aHR 1.66:95%CI;1.02-2.71), having either extra-pulmonary disease (aHR 2.21:95%CI;1.26-3.89) or both pulmonary and extrapulmonary disease (aHR 3.03:95%CI;1.70-5.40).Mortality was high and occurred early during treatment in this cohort, likely indicative of poor access to prompt TB diagnosis and treatment. A redoubling of efforts at improving universal health coverage are required to achieve the End TB Strategy target of zero deaths from TB. |
| first_indexed | 2024-12-21T12:12:40Z |
| format | Article |
| id | doaj.art-f5daa4dbe88e431c902584caae33ed5b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T12:12:40Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f5daa4dbe88e431c902584caae33ed5b2022-12-21T19:04:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018327010.1371/journal.pone.0183270Deaths during tuberculosis treatment among paediatric patients in a large tertiary hospital in Nigeria.Aishatu L AdamuMuktar H AliyuNajiba Aliyu GaladanciBaba Maiyaki MusaMuktar A GadanyaAuwalu U GajidaTaiwo G AmoleImam W BelloSafiya GamboIbrahim AbubakarDespite availability of effective cure, tuberculosis (TB) remains a leading cause of death in children. In many high-burden countries, childhood TB is underdiagnosed and underreported, and care is often accessed too late, resulting in adverse treatment outcomes. In this study, we examined the time to death and its associated factors among a cohort of children that commenced TB treatment in a large treatment centre in northern Nigeria.This is a retrospective cohort study of children that started TB treatment between 2010 and 2014. We determined mortality rates per 100 person-months of treatment, as well as across treatment and calendar periods. We used Cox proportional hazards regression to determine adjusted hazard ratios (aHR) for factors associated with mortality.Among 299 children with a median age 4 years and HIV prevalence of 33.4%; 85 (28.4%) died after 1,383 months of follow-up. Overall mortality rate was 6.1 per 100 person-months. Deaths occurred early during treatment and declined from 42.4 per 100 person-months in the 1st week of treatment to 2.2 per 100 person-months after at the 3rd month of treatment. Mortality was highest between October to December period (9.1 per 100 pm) and lowest between July and September (2.8 per 100 pm). Risk factors for mortality included previous TB treatment (aHR 2.04:95%CI;1.09-3.84); HIV infection (aHR 1.66:95%CI;1.02-2.71), having either extra-pulmonary disease (aHR 2.21:95%CI;1.26-3.89) or both pulmonary and extrapulmonary disease (aHR 3.03:95%CI;1.70-5.40).Mortality was high and occurred early during treatment in this cohort, likely indicative of poor access to prompt TB diagnosis and treatment. A redoubling of efforts at improving universal health coverage are required to achieve the End TB Strategy target of zero deaths from TB.http://europepmc.org/articles/PMC5560640?pdf=render |
| spellingShingle | Aishatu L Adamu Muktar H Aliyu Najiba Aliyu Galadanci Baba Maiyaki Musa Muktar A Gadanya Auwalu U Gajida Taiwo G Amole Imam W Bello Safiya Gambo Ibrahim Abubakar Deaths during tuberculosis treatment among paediatric patients in a large tertiary hospital in Nigeria. PLoS ONE |
| title | Deaths during tuberculosis treatment among paediatric patients in a large tertiary hospital in Nigeria. |
| title_full | Deaths during tuberculosis treatment among paediatric patients in a large tertiary hospital in Nigeria. |
| title_fullStr | Deaths during tuberculosis treatment among paediatric patients in a large tertiary hospital in Nigeria. |
| title_full_unstemmed | Deaths during tuberculosis treatment among paediatric patients in a large tertiary hospital in Nigeria. |
| title_short | Deaths during tuberculosis treatment among paediatric patients in a large tertiary hospital in Nigeria. |
| title_sort | deaths during tuberculosis treatment among paediatric patients in a large tertiary hospital in nigeria |
| url | http://europepmc.org/articles/PMC5560640?pdf=render |
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