Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and Disease
Inorganic polyphosphate (polyP), a simple anionic polymer consisting of even hundreds of orthophosphate units, is a universal molecule present in both simple and complex organisms. PolyP controls homeostatic processes in animals, such as blood coagulation, tissue regeneration, and energy metabolism....
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/4/913 |
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| author | Filip Kus Ryszard T. Smolenski Marta Tomczyk |
| author_facet | Filip Kus Ryszard T. Smolenski Marta Tomczyk |
| author_sort | Filip Kus |
| collection | DOAJ |
| description | Inorganic polyphosphate (polyP), a simple anionic polymer consisting of even hundreds of orthophosphate units, is a universal molecule present in both simple and complex organisms. PolyP controls homeostatic processes in animals, such as blood coagulation, tissue regeneration, and energy metabolism. Furthermore, this polymer is a potent regulator of inflammation and influences host immune response in bacterial and viral infections. Disturbed polyP systems have been related to several pathological conditions, including neurodegeneration, cardiovascular disorders, and cancer, but we lack a full understanding of polyP biogenesis and mechanistic insights into the pathways through which polyP may act. This review summarizes recent studies that describe the role of polyP in cell homeostasis and show how disturbances in polyP levels may lead to disease. Based on the collected findings, we highlight the possible usage of this polymer as a promising therapeutic tool in multiple pathologies. |
| first_indexed | 2024-03-09T11:06:40Z |
| format | Article |
| id | doaj.art-f5dcd2a25e164a6d9af04a4736c37e52 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T11:06:40Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-f5dcd2a25e164a6d9af04a4736c37e522023-12-01T00:56:25ZengMDPI AGBiomedicines2227-90592022-04-0110491310.3390/biomedicines10040913Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and DiseaseFilip Kus0Ryszard T. Smolenski1Marta Tomczyk2Laboratory of Molecular Biology, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, 80-307 Gdansk, PolandDepartment of Biochemistry, Medical University of Gdansk, 80-211 Gdansk, PolandDepartment of Biochemistry, Medical University of Gdansk, 80-211 Gdansk, PolandInorganic polyphosphate (polyP), a simple anionic polymer consisting of even hundreds of orthophosphate units, is a universal molecule present in both simple and complex organisms. PolyP controls homeostatic processes in animals, such as blood coagulation, tissue regeneration, and energy metabolism. Furthermore, this polymer is a potent regulator of inflammation and influences host immune response in bacterial and viral infections. Disturbed polyP systems have been related to several pathological conditions, including neurodegeneration, cardiovascular disorders, and cancer, but we lack a full understanding of polyP biogenesis and mechanistic insights into the pathways through which polyP may act. This review summarizes recent studies that describe the role of polyP in cell homeostasis and show how disturbances in polyP levels may lead to disease. Based on the collected findings, we highlight the possible usage of this polymer as a promising therapeutic tool in multiple pathologies.https://www.mdpi.com/2227-9059/10/4/913inorganic polyphosphateinflammationneurodegenerative diseasesSARS-CoV-2cancer |
| spellingShingle | Filip Kus Ryszard T. Smolenski Marta Tomczyk Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and Disease Biomedicines inorganic polyphosphate inflammation neurodegenerative diseases SARS-CoV-2 cancer |
| title | Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and Disease |
| title_full | Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and Disease |
| title_fullStr | Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and Disease |
| title_full_unstemmed | Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and Disease |
| title_short | Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and Disease |
| title_sort | inorganic polyphosphate regulator of cellular metabolism in homeostasis and disease |
| topic | inorganic polyphosphate inflammation neurodegenerative diseases SARS-CoV-2 cancer |
| url | https://www.mdpi.com/2227-9059/10/4/913 |
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