Self-repair in a Bidirectionally Coupled Astrocyte-Neuron (AN) System based on Retrograde Signaling

Self-repair in a Bidirectionally Coupled Astrocyte-Neuron (AN) System based on Retrograde Signaling

In this paper we demonstrate that retrograde signaling via astrocytes may underpin self-repair in the brain. Faults manifest themselves in silent or near silent neurons caused by low transmission probability synapses; the enhancement of the transmission probability of a healthy neighbouring synapse...

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Bibliographic Details
Main Authors: John eWade, Liam J McDaid, Jim eHarkin, Vincenzo eCrunelli, Scott eKelso
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Computational Neuroscience
Subjects:
Neuron
astrocyte
synapse
calcium wave
endocannabinoid
IP3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncom.2012.00076/full

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