Design and synthesis of chitosan/calcium lignosulfonate/Au NPs: Its performance for reduction of nitro compounds and in the treatment of cancer
This work introduces the preparation of a novel type of crosslinked polymers support based on calcium lignosulfonate-chitosan (CLS-CS) hydrogel with capping/reducing ability to encapsulated gold nanoparticles (CLS-CS/Au NPs). The morphology, structure and physicochemical properties of the prepared n...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
|
| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535224001114 |
| _version_ | 1827311245521321984 |
|---|---|
| author | Ruyi Xie Jianming Zhou Ting Wang Yuan Xu Bei Zhang Sally Negm Attalla F. Elkott |
| author_facet | Ruyi Xie Jianming Zhou Ting Wang Yuan Xu Bei Zhang Sally Negm Attalla F. Elkott |
| author_sort | Ruyi Xie |
| collection | DOAJ |
| description | This work introduces the preparation of a novel type of crosslinked polymers support based on calcium lignosulfonate-chitosan (CLS-CS) hydrogel with capping/reducing ability to encapsulated gold nanoparticles (CLS-CS/Au NPs). The morphology, structure and physicochemical properties of the prepared nanoparticles were characterized by different analytical techniques such as FT-IR, FE-SEM, TEM, EDX-elemental mapping study. The obtained results shown that CLS-CS/Au NPs prepared as spherical particles with sizes of 20–30 nm. The CLS-CS/Au NPs was applied as well for reduction of nitroarenes. The reduction of nitroarenes was obtained with good to high yields within short times. The related nanocatalyst was recovered for eight runs without significant loss of its catalytic performance. The MTT examination was conducted to check the anti-pancreatic cancer, anti-gastric cancer, anti-colorectal carcinoma, and cytotoxicity efficacies of the treated cells with CLS-CS/Au NPs over a 48-hour period on normal (HUVEC) and cancer cells. The IC50 values of the CLS-CS/Au NPs were found to be 169 µg/mL for HT-29 (colorectal carcinoma cell), 196 µg/mL for MKN45 (Gastric cancer cell), and 112 µg/mL for PANC-1 (Pancreatic cancer cell). The growth of malignant colorectal, gastric and pancreatic cells was found to decrease in a dose-dependent manner when exposed to CLS-CS/Au NPs. Following clinical research, CLS-CS/Au NPs shows promise as an effective treatment for colorectal, gastric and pancreatic cancers. |
| first_indexed | 2024-04-24T20:13:43Z |
| format | Article |
| id | doaj.art-f5e0197b756643d8afefe527fd5b7f3d |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-24T20:13:43Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-f5e0197b756643d8afefe527fd5b7f3d2024-03-23T06:23:45ZengElsevierArabian Journal of Chemistry1878-53522024-04-01174105709Design and synthesis of chitosan/calcium lignosulfonate/Au NPs: Its performance for reduction of nitro compounds and in the treatment of cancerRuyi Xie0Jianming Zhou1Ting Wang2Yuan Xu3Bei Zhang4Sally Negm5Attalla F. Elkott6Gastroenterology Department, The 2nd Affiliated Hospital of Nanchang University, Jiangxi 330006, ChinaGastroenterology Department, The 2nd Affiliated Hospital of Nanchang University, Jiangxi 330006, ChinaGastroenterology Department, The 2nd Affiliated Hospital of Nanchang University, Jiangxi 330006, ChinaInformation Department, The 2nd Affiliated Hospital of Nanchang University, Jiangxi 330006, ChinaGastroenterology Department, The 2nd Affiliated Hospital of Nanchang University, Jiangxi 330006, China; Corresponding author.Department of Life Sciences, College of Science and Art Mahyel Aseer, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Biology, College of Science, King Khalid University, 61421 Abha, Saudi Arabia; Department of Zoology, Faculty of Science, Damanhour University, Damanhour 22511, EgyptThis work introduces the preparation of a novel type of crosslinked polymers support based on calcium lignosulfonate-chitosan (CLS-CS) hydrogel with capping/reducing ability to encapsulated gold nanoparticles (CLS-CS/Au NPs). The morphology, structure and physicochemical properties of the prepared nanoparticles were characterized by different analytical techniques such as FT-IR, FE-SEM, TEM, EDX-elemental mapping study. The obtained results shown that CLS-CS/Au NPs prepared as spherical particles with sizes of 20–30 nm. The CLS-CS/Au NPs was applied as well for reduction of nitroarenes. The reduction of nitroarenes was obtained with good to high yields within short times. The related nanocatalyst was recovered for eight runs without significant loss of its catalytic performance. The MTT examination was conducted to check the anti-pancreatic cancer, anti-gastric cancer, anti-colorectal carcinoma, and cytotoxicity efficacies of the treated cells with CLS-CS/Au NPs over a 48-hour period on normal (HUVEC) and cancer cells. The IC50 values of the CLS-CS/Au NPs were found to be 169 µg/mL for HT-29 (colorectal carcinoma cell), 196 µg/mL for MKN45 (Gastric cancer cell), and 112 µg/mL for PANC-1 (Pancreatic cancer cell). The growth of malignant colorectal, gastric and pancreatic cells was found to decrease in a dose-dependent manner when exposed to CLS-CS/Au NPs. Following clinical research, CLS-CS/Au NPs shows promise as an effective treatment for colorectal, gastric and pancreatic cancers.http://www.sciencedirect.com/science/article/pii/S1878535224001114ChitosanLignosulfonateGold nanoparticlesCancerMTT assay |
| spellingShingle | Ruyi Xie Jianming Zhou Ting Wang Yuan Xu Bei Zhang Sally Negm Attalla F. Elkott Design and synthesis of chitosan/calcium lignosulfonate/Au NPs: Its performance for reduction of nitro compounds and in the treatment of cancer Arabian Journal of Chemistry Chitosan Lignosulfonate Gold nanoparticles Cancer MTT assay |
| title | Design and synthesis of chitosan/calcium lignosulfonate/Au NPs: Its performance for reduction of nitro compounds and in the treatment of cancer |
| title_full | Design and synthesis of chitosan/calcium lignosulfonate/Au NPs: Its performance for reduction of nitro compounds and in the treatment of cancer |
| title_fullStr | Design and synthesis of chitosan/calcium lignosulfonate/Au NPs: Its performance for reduction of nitro compounds and in the treatment of cancer |
| title_full_unstemmed | Design and synthesis of chitosan/calcium lignosulfonate/Au NPs: Its performance for reduction of nitro compounds and in the treatment of cancer |
| title_short | Design and synthesis of chitosan/calcium lignosulfonate/Au NPs: Its performance for reduction of nitro compounds and in the treatment of cancer |
| title_sort | design and synthesis of chitosan calcium lignosulfonate au nps its performance for reduction of nitro compounds and in the treatment of cancer |
| topic | Chitosan Lignosulfonate Gold nanoparticles Cancer MTT assay |
| url | http://www.sciencedirect.com/science/article/pii/S1878535224001114 |
| work_keys_str_mv | AT ruyixie designandsynthesisofchitosancalciumlignosulfonateaunpsitsperformanceforreductionofnitrocompoundsandinthetreatmentofcancer AT jianmingzhou designandsynthesisofchitosancalciumlignosulfonateaunpsitsperformanceforreductionofnitrocompoundsandinthetreatmentofcancer AT tingwang designandsynthesisofchitosancalciumlignosulfonateaunpsitsperformanceforreductionofnitrocompoundsandinthetreatmentofcancer AT yuanxu designandsynthesisofchitosancalciumlignosulfonateaunpsitsperformanceforreductionofnitrocompoundsandinthetreatmentofcancer AT beizhang designandsynthesisofchitosancalciumlignosulfonateaunpsitsperformanceforreductionofnitrocompoundsandinthetreatmentofcancer AT sallynegm designandsynthesisofchitosancalciumlignosulfonateaunpsitsperformanceforreductionofnitrocompoundsandinthetreatmentofcancer AT attallafelkott designandsynthesisofchitosancalciumlignosulfonateaunpsitsperformanceforreductionofnitrocompoundsandinthetreatmentofcancer |